Indian Journal of Animal Research

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Research Article

Indian Journal of Animal Research, volume 53 issue 4 (april 2019) : 523-527

Baicalein ameliorates cadmium-induced hepatic and renal oxidative damage in rats

Jicang Wang, Huali Zhu, Cai Zhang, Hongwei Wang, Zijun Yang
1College of Animal Science and Technology, Henan University of Science and Technology, No. 263, Kaiyuan Avenue, 471023, Luoyang, PR China.
Cite article:- Wang Jicang, Zhu Huali, Zhang Cai, Wang Hongwei, Yang Zijun (2018). Baicalein ameliorates cadmium-induced hepatic and renal oxidative damage in rats. Indian Journal of Animal Research. 53(4): 523-527. doi: 10.18805/ijar.B-853.

ABSTRACT

Cadmium (Cd)-induced oxidative damage of liver and kidney and the ameliorative impact of baicalein against hepatotoxicity and nephrotoxicity of rats was studied. Male SD rats were handled with either intraperitoneal cadmium (CdCl2, 2mg/kg) and/or oral baicalein (100 mg/kg) for 4 weeks. The results demonstrated that Cd increased the level of GPT, GOT, BUN in serum and the contents of MDA, GSH, decreased the activities of SOD, CAT, GSH-Px in tissues versus control. Conversely, administration of baicalein restored the changes in these parameters to nearly normal levels. The results suggested that the ameliorative impact of baicalein might be because of its antioxidant properties in combating free radical-induced oxidative stress resulting from cadmium chloride.

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