Baicalein ameliorates cadmium-induced hepatic and renal oxidative damage in rats

DOI: 10.18805/ijar.B-853    | Article Id: B-853 | Page : 523-527
Citation :- Baicalein ameliorates cadmium-induced hepatic and renal oxidative damage in rats.Indian Journal Of Animal Research.2019.(53):523-527
Jicang Wang, Huali Zhu, Cai Zhang, Hongwei Wang and Zijun Yang wangjicang@126.com
Address : College of Animal Science and Technology, Henan University of Science and Technology, No. 263, Kaiyuan Avenue, 471023, Luoyang, PR China.
Submitted Date : 25-10-2017
Accepted Date : 12-01-2018

Abstract

Cadmium (Cd)-induced oxidative damage of liver and kidney and the ameliorative impact of baicalein against hepatotoxicity and nephrotoxicity of rats was studied. Male SD rats were handled with either intraperitoneal cadmium (CdCl2, 2mg/kg) and/or oral baicalein (100 mg/kg) for 4 weeks. The results demonstrated that Cd increased the level of GPT, GOT, BUN in serum and the contents of MDA, GSH, decreased the activities of SOD, CAT, GSH-Px in tissues versus control. Conversely, administration of baicalein restored the changes in these parameters to nearly normal levels. The results suggested that the ameliorative impact of baicalein might be because of its antioxidant properties in combating free radical-induced oxidative stress resulting from cadmium chloride.

Keywords

Baicalein Cadmium kidney Liver Oxidative stress.

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