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Current IssueEditorial BoardOnline First ArticlesArchive

Short Communication

volume 52 issue 7 (july 2018) : 1068-1070,   Doi: 10.18805/ijar.B-847

Evaluation of autologous and homologous platelet rich plasma as a surgical wound healing promoter in rabbits

M
Muhammad Shahid Tahir
U
Uzma Farid Durrani
A
Asim Khalid Mahmood
R
Raheela Akhtar
R
Rashid Hussain
A
Abid Hussain
K
Khizar Matloob
B
Beenish Zahid
1Pet Centre, University of Veterinary and Animal Sciences, Lahore-54000, Pakistan.
Cite article:- Tahir Shahid Muhammad, Durrani Farid Uzma, Mahmood Khalid Asim, Akhtar Raheela, Hussain Rashid, Hussain Abid, Matloob Khizar, Zahid Beenish (2018). Evaluation of autologous and homologous platelet rich plasma as a surgical wound healing promoter in rabbits. Indian Journal of Animal Research. 52(7): 1068-1070. doi: 10.18805/ijar.B-847.

ABSTRACT

The present study compared the efficacy of autologous and homologous platelet rich plasma (PRP) as a surgical wound healing promoter in rabbits. Sixteen adult healthy rabbits were divided into two groups i.e. A & B. Group A was treated with autologous platelet rich plasma (APRP) and group B was treated with homologous platelet rich plasma (HPRP). Both groups were operated for skin grafting (auto grafting) at two (PRP treated experimental and control) sites. Clinical evaluation of PRP was performed by using macroscopic (edema, exudation, coloration, temperature, cosmetic appearance and healing status) and microscopic (acute inflammation, fibroblast proliferation and granulation tissue proliferation) parameters. The healing status, coloration and cosmetic appearance of APRP treated group were more satisfactory than HPRP treated group. APRP group also showed less inflammation, edema and more granular tissue proliferation as compare to HPRP group. It was concluded that autologous PRP is an efficient surgical wound healing promoter in rabbits.

REFERENCES

  1. Akhundov, K., Pietramaggiori, G., Waselle, L., Darwiche, S., Guerid, S., Scaletta, C. et al . (2012). Development of a cost-effective method for platelet-rich plasma (PRP) preparation for topical wound healing. Annals of Burns and Fire.Disasters, 25: 207-    213.
  2. Bottegoni, C., Giudici, L.D., Salvemini, S., Chiurazzi, E., Bencivenga, R. and Gigante, A. (2016) Homologous platelet-rich plasma for the treatment of knee osteoarthritis in selected elderly patients: an open-label, uncontrolled, pilot study. Therapeutic Advances in Musculoskeletal Diseases, 8: 35-41.
  3. Bhanot, S. and Alex, J.C. (2002). Current applications of platelet gels in facial plastic surgery. Facial Plastic Surgery, 18:27-34.
  4. Del, C.M., Vervelle, A., Simonpieri, A., Jimbo, R., Inchingolo, F., Sammartino, G. and Ehrenfest, D.M. (2012). Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 1: Periodontal and dentoalveolar surgery. Current Pharmaceutical. Biotechnology, 13: 207-230.
  5. Hermeto, L.C., de-Rossi, R., de-Pádua, S.B., Pontes, E.R.J. and Santana, A.E. (2012). Comparative study between fibrin glue and platelet rich plasma in dogs skin grafts. Acta. Cirúrgica. Brasileira. 27: 789-794
  6. Kakudo, N., Kushida, S., Ogura, T., Hara, T., Suzuki, K. and Kusumoto, K. (2012). The use of autologous platelet-rich plasma in the treatment of intractable skin ulcer: a case series. Open Journal of Regenerative Medicine, 1: 29-32.
  7. Lee, K.S. (2016). Ultrasound-guided platelet-rich plasma treatment: application and technique. Seminars in Musculoskeletal Radiology, 20: 422-431. 
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Indian Journal of Animal Research
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    Short Communication

    volume 52 issue 7 (july 2018) : 1068-1070,   Doi: 10.18805/ijar.B-847

    Evaluation of autologous and homologous platelet rich plasma as a surgical wound healing promoter in rabbits

    M
    Muhammad Shahid Tahir
    U
    Uzma Farid Durrani
    A
    Asim Khalid Mahmood
    R
    Raheela Akhtar
    R
    Rashid Hussain
    A
    Abid Hussain
    K
    Khizar Matloob
    B
    Beenish Zahid
    1Pet Centre, University of Veterinary and Animal Sciences, Lahore-54000, Pakistan.
    Cite article:- Tahir Shahid Muhammad, Durrani Farid Uzma, Mahmood Khalid Asim, Akhtar Raheela, Hussain Rashid, Hussain Abid, Matloob Khizar, Zahid Beenish (2018). Evaluation of autologous and homologous platelet rich plasma as a surgical wound healing promoter in rabbits. Indian Journal of Animal Research. 52(7): 1068-1070. doi: 10.18805/ijar.B-847.

    ABSTRACT

    The present study compared the efficacy of autologous and homologous platelet rich plasma (PRP) as a surgical wound healing promoter in rabbits. Sixteen adult healthy rabbits were divided into two groups i.e. A & B. Group A was treated with autologous platelet rich plasma (APRP) and group B was treated with homologous platelet rich plasma (HPRP). Both groups were operated for skin grafting (auto grafting) at two (PRP treated experimental and control) sites. Clinical evaluation of PRP was performed by using macroscopic (edema, exudation, coloration, temperature, cosmetic appearance and healing status) and microscopic (acute inflammation, fibroblast proliferation and granulation tissue proliferation) parameters. The healing status, coloration and cosmetic appearance of APRP treated group were more satisfactory than HPRP treated group. APRP group also showed less inflammation, edema and more granular tissue proliferation as compare to HPRP group. It was concluded that autologous PRP is an efficient surgical wound healing promoter in rabbits.

    REFERENCES

    1. Akhundov, K., Pietramaggiori, G., Waselle, L., Darwiche, S., Guerid, S., Scaletta, C. et al . (2012). Development of a cost-effective method for platelet-rich plasma (PRP) preparation for topical wound healing. Annals of Burns and Fire.Disasters, 25: 207-    213.
    2. Bottegoni, C., Giudici, L.D., Salvemini, S., Chiurazzi, E., Bencivenga, R. and Gigante, A. (2016) Homologous platelet-rich plasma for the treatment of knee osteoarthritis in selected elderly patients: an open-label, uncontrolled, pilot study. Therapeutic Advances in Musculoskeletal Diseases, 8: 35-41.
    3. Bhanot, S. and Alex, J.C. (2002). Current applications of platelet gels in facial plastic surgery. Facial Plastic Surgery, 18:27-34.
    4. Del, C.M., Vervelle, A., Simonpieri, A., Jimbo, R., Inchingolo, F., Sammartino, G. and Ehrenfest, D.M. (2012). Current knowledge and perspectives for the use of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) in oral and maxillofacial surgery part 1: Periodontal and dentoalveolar surgery. Current Pharmaceutical. Biotechnology, 13: 207-230.
    5. Hermeto, L.C., de-Rossi, R., de-Pádua, S.B., Pontes, E.R.J. and Santana, A.E. (2012). Comparative study between fibrin glue and platelet rich plasma in dogs skin grafts. Acta. Cirúrgica. Brasileira. 27: 789-794
    6. Kakudo, N., Kushida, S., Ogura, T., Hara, T., Suzuki, K. and Kusumoto, K. (2012). The use of autologous platelet-rich plasma in the treatment of intractable skin ulcer: a case series. Open Journal of Regenerative Medicine, 1: 29-32.
    7. Lee, K.S. (2016). Ultrasound-guided platelet-rich plasma treatment: application and technique. Seminars in Musculoskeletal Radiology, 20: 422-431. 
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