Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

  • Print ISSN 0367-6722

  • Online ISSN 0976-0555

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Indian Journal of Animal Research, volume 51 issue 4 (august 2017) : 747-751

Ischemia modified albumin as an early biomarker in diagnosing the late stages abortus in cows

Beran Yokus, Nazli Ercan, Ulvi Reha Fidancý, Mustafa Can Gün
1<p>Department of Biochemistry,&nbsp;Faculty of Veterinary Medicine, Dicle University, Diyarbak&yacute;r, Turkey.</p>
Cite article:- Yokus Beran, Ercan Nazli, Fidanc&yacute; Reha Ulvi, G&uuml;n Can Mustafa (2017). Ischemia modified albumin as an early biomarker in diagnosing the late stages abortus in cows . Indian Journal of Animal Research. 51(4): 747-751. doi: 10.18805/ijar.v0iOF.8462.

Nowadays, Ischemia Modified Albumin (IMA) has been regarded as an indicator for various maladies and complicated pregnancy in humans. Therefore, it is hypothesized that evaluation of the maternal serum IMA degrees can serve as an early detection of abortion in dairy cows. 252 Holstein cows’ serum samples were taken both in the 2nd and 6th months of their pregnancy. Twenty-two cattle were selected as a positive control group among the non aborted ones. Furthermore, blood samples from 20 non-pregnant cows were taken to identify the effects of physiological changes of pregnancy. IMA and Ischemia Modified Albumin Rate (IMAR) were markedly higher (p<0.01); and albumin was markedly lower (p<0.01) in aborted cows and healthy-pregnant cows compared with non-pregnant cows in both months. In aborted cows, IMA, IMAR and Oxidative stress index (OSI) degrees were found to be more increased than healthy pregnancies both in 2nd and 6th months of pregnancy; however, there were statistically significant only at 6th month (p<0.01). Total Oxidative Stress (TOS) levels were higher than healthy pregnancies. So, as a result of IMA which was caused by oxidative stress rising from hypoxia/ischemia could serve as an early bioindicator for miscarriage in cattle. 

  1. Al-Samarai, F.R., Abdulrahman, Y.K., Ibrahim, W.I. and Al-Nedawi, A.M. (2012). Effect of some environmental factors on abortion and offspring sex ratio in Holstein cows in Iraq. Int J Sci Nat, 3: 361-365.

  2. Bahinipati, J., Mohapatra, P.C. and Pradhan, T. (2014). Role of maternal serum ischemia modified albumin as a biochemical marker in preeclampsia. Biomedical Research (India), 25: 153-156.

  3. Cengiz, H., Dagdeviren, H., Kanawati, A., Suzen Caypinar, S., Yesil, A., Ekin, M. and Yasar, l. (2015). Ischemia-modified albumin as an oxidative stress biomarker in early pregnancy loss. J Matern Fetal and Neonatal Med, 16: 1754-1757.

  4. Dahiya, K., Kulshrestha, M.R., Bansal, P., Ghalaut, V.S., Kulshrestha, R., Dahiya, P. and Dhupper, V. (2015). Evaluation of cord blood ischemia modified albumin in normal pregnancies and pre-eclampsia. Hypertens Pregnancy, 34: 204-208.

  5. Dogan, K., Guraslan, H., Cankaya, A., Dagdeviren, H. and Ekin, M. (2015). Ischemia-modified albumin (ima): a novel marker for preeclampsia independent of uterine artery notching identified by dopler ultrasound. Hypertens Pregnancy, 34: 516-524.

  6. Dursun, A., Okumus, N. and Zenciroglu, A. (2012). Ischemia-modified albumin (ima): Could it be useful to predict perinatal asphyxia. J Matern Fetal Neonatal Med, 25: 2401-2405.

  7. Erel, O. (2005). A new automated colorimetric method for measuring total oxidant status. Clin Biochem, 38: 1103–1111.

  8. Gugliucci, A., Hermo, R., Monroy, C., Numaguchi, M. and Kimura S. (2005). Ischemia-modified adjoining levels in cord blood: a case-    control study in uncomplicated and complicated deliveries. Clin Chim Acta, 362: 155–160.

  9. Gunduz, A., Turkmen, S., Turedi, S., Mentese, A., Yulug, E., Ulusoy, H., Karahan, C.S. and Topbas, M. (2009). Time-dependent variations in ischemia-modified albumin levels in mesenteric ischemia. Acad Emerg Med, 16: 539-543.

  10. Guven, S., Alver, A., Mentese, A., Ilhan, F.C., Calapoglu, M. and Unsal, M.A. (2009). The novel ischemia marker ‘ischemia-modified albumin’ is increased in normal pregnancies. Acta Obstet Gynecol Scand, 88: 479–482.

  11. Hovingh, E. (2002). Abortions in dairy cattle. 1. common causes of abortions. http:// .vir. coo. ext.

  12. Jauniaux, E., Watson, A. and Burton, G. (2001). Evaluation of respiratory gases and acid-base gradients in human fetal fluids and uteroplacental tissue between 7 and 16 weeks’ gestation. Am J Obstet Gynecol, 184: 998 1003.

  13. Karadeniz, O., Mendilcioglu, I., Ozdem, S., Ozekinci, M., Sanhal, C.Y., Uzun, G., Sakinci, M. and Simsek, M. (2015). The association between ischaemia-modified albumin levels in umbilical vein and intrauterine growth restriction. J Obstet Gynecol, 35: 9-12.

  14. King, W.A. (1990). Chromosome abnormalities and pregnancy failure in domestic animals. Advanc Vet Sci Comparat Med, 34: 229 – 234.

  15. Kotani, K., Kimura, S. and Gugliucci A. (2011). Paraoxonase-1 and ischemia-modified albumin in patients with end-stage renal disease. J Physiol Biochem, 67: 437–441.

  16. Kragh-Hansen, U. (1990). Structure and ligand binding properties of human serum albumin. Dan Med Bull, 37: 57–84.

  17. Lippi, G., Montagnana, M., Salvagno, G.L. and Guidi, G.C. (2006). Potential value for new diagnostic markers in the early recognition of acute coronary syndromes. Canad J Emerge Med, 8: 27–31.

  18. Ozdemir, S., Kiyici, A., Balci, O., Goktepe, H., Cicekler, H. and Celik C. (2011). Assessment of ischemia-modified albumin level in patients with recurrent pregnancy loss during the first trimester. Europan J Obstet Gynecol Reproduct Biol, 155: 209–212.

  19. Papageorghiou, A.T., Prefumo, F., Leslie, K., Gaze, D.C., Collinson, P.O. and Thlaganathan, B. (2008). Defective endovascular trophoblast invasion in the first trimester is associated with increased maternal serum ischemiamodifid albumin. Human Reproduct, 23: 803–806.

  20. Prefumo, F., Gaze, D.C., Papageorghiou, A.T., Collinson, P.O. and Thlaganathan B. (2007). First trimester maternal serum ischaemia-    modified albumin: a marker of hypoxia-ischaemia-driven early trophoblast development. Human Reproduct, 22: 2029–2032.

  21. Refaai, M.A., Wright, R.W., Parvin, C.A., Gronowski, A.M., Scott, M.G. and Eby, C.S. (2006). Ischemia modified albumin increases after skeletal muscle ischemia during arthroscopic knee surgery. Clin Chim Acta, 366: 264–8.

  22. Shen, X.L., Lin, C.J., Han, L.L., Lin, L., Pan, L. and Pu X.D. (2011). Assessment of ischemia-modified albumin levels for emergency room diag- nosis of acute coronary syndrome. Int J Cardiol, 149: 296–298.

  23. Ukinc, K., Eminagaoglu, S., Ersoz, H.O. Erem, C., Karahan, C., Haciihsanglu, A.B. and Kocak, M. (2009). A novel indicator of widespread endothelial damage and ischemia in diabetic patients: ischemia-modified albumin. Endocrine, 36: 425–432.

  24. Ustun, Y., Engin-Ustun, Y., Ozturk, O., Alanbay, I. and Yaman, H. (2011). Ischemia-modified albumin as an oxidative stress marker in preeclampsia. J Matern Fetal Neonatal Med, 24: 418–21.

  25. Van Rijn, B.B., Franx, A., Sikkema, J.M., Van Rijn, H.J., Brunse, H.W. and Voorbij, H.A. (2008). Ischemia modified albumin in normal pregnancy and pre-eclampsia. Hypertens Pregnancy, 27: 159–167.


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