Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

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Indian Journal of Animal Research, volume 51 issue 4 (august 2017) : 717-721

Effects of lipopolysaccharide on the growth performance, nitrogen metabolism and immunity in preruminant calves

N Zhang, H Li, C Jiang, Y Tu, Q Diao
1<p>Feed Research Institute of Chinese Academy of Agricultural Sciences /&nbsp;Key Laboratory of Feed Biotechnology of the Ministry of Agriculture, Beijing 100081, China.</p>
Cite article:- Zhang N, Li H, Jiang C, Tu Y, Diao Q (2016). Effects of lipopolysaccharide on the growth performance, nitrogenmetabolism and immunity in preruminant calves . Indian Journal of Animal Research. 51(4): 717-721. doi: 10.18805/ijar.v0iOF.6831.

To investigate the effect of lipopolysaccharides (LPS) on the growth performance, nitrogen metabolism and immunity in preruminant calves, forty Chinese Holstein male calves were randomly divided into two groups and injected intraperitoneally with 2.5 mg/kg BW of sterile saline or E. coli LPS (Escherichia coli O55:b55) on day 24, 26, and 28. The LPS challenge decreased average daily gain and feed conversion efficiency compared with control group (p<0.05). The urinary concentration of nitrogen (p<0.05) increased, whereas the nitrogen retention decreased (p<0.05) after LPS-challenge. Injection of LPS increased body temperature, serum concentration of IL-1, TNF-a, IL-2 and IgG of calves. In conclusion, LPS-challenge activated immune responses, decreased utilization efficiency of nitrogen, and negatively impacted growth performance of preruminant calves. 

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