Indian Journal of Animal Research

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Research Article

Indian Journal of Animal Research, volume 51 issue 4 (august 2017) : 717-721

Effects of lipopolysaccharide on the growth performance, nitrogen metabolism and immunity in preruminant calves

N Zhang, H Li, C Jiang, Y Tu, Q Diao
1<p>Feed Research Institute of Chinese Academy of Agricultural Sciences /&nbsp;Key Laboratory of Feed Biotechnology of the Ministry of Agriculture, Beijing 100081, China.</p>
Cite article:- Zhang N, Li H, Jiang C, Tu Y, Diao Q (2016). Effects of lipopolysaccharide on the growth performance, nitrogenmetabolism and immunity in preruminant calves . Indian Journal of Animal Research. 51(4): 717-721. doi: 10.18805/ijar.v0iOF.6831.

ABSTRACT

To investigate the effect of lipopolysaccharides (LPS) on the growth performance, nitrogen metabolism and immunity in preruminant calves, forty Chinese Holstein male calves were randomly divided into two groups and injected intraperitoneally with 2.5 mg/kg BW of sterile saline or E. coli LPS (Escherichia coli O55:b55) on day 24, 26, and 28. The LPS challenge decreased average daily gain and feed conversion efficiency compared with control group (p<0.05). The urinary concentration of nitrogen (p<0.05) increased, whereas the nitrogen retention decreased (p<0.05) after LPS-challenge. Injection of LPS increased body temperature, serum concentration of IL-1, TNF-a, IL-2 and IgG of calves. In conclusion, LPS-challenge activated immune responses, decreased utilization efficiency of nitrogen, and negatively impacted growth performance of preruminant calves. 

REFERENCES


  1. Abbas, A. K., Murphy, K. M. and Sher, A. (1996). Functional diversity of helper t lymphocytes. Nature 383: 787-793.

  2. Amel-Kashipaz, M. (2001). Quantitative and qualitative analysis of the balance between type 1 and type 2 cytokine-    producing cd8-and cd8+t cells in systemic lupus erythematosus. J. Autoimmun. 17: 155-163.

  3. AOAC. (2005). Official methods of analysis. 18th ed. GAITHERSBURG, USA: AOAC international.

  4. AOAC. (2000). Official methods of analysis. 15th ed. Arlington: Association of official Analytical Chemists.

  5. Balaji, R., Wright, K. J., Hill, C. M., Dritz, S. S., Knoppel, E. L. and Minton, J. E. (2000). Acute phase responses of pigs challenged orally with salmonella typhimurium. J. Anim. Sci. 78: 1885-1891.

  6. Berczi, I., Bertok, L. and Bereznai, T. (1966). Comparative studies on the toxicity of escherichia coli lipopolysaccharide endotoxin in various animal species. Can. J. Microbiol. 12: 1070-1071.

  7. Bosi, P., Casini, L., Finamore, A., Cremokolini, C., Merialdi, G., Trevisi, P., Nobili, F. and Mengheri, E. (2004). Spray-    dried plasma improves growth performance and reduces inflammatory status of weaned pigs challenged with enterotoxigenic escherichia coli k88. J. Anim. Sci. 82: 1764-1772.

  8. Burdick Sanchez, N. C., Carroll, J. A., Randel, R. D., Vann, R. C. and Welsh, T. H. (2014). Associations between endotoxin-    induced metabolic changes and temperament in brahman bulls. J. Anim. Physiol. An. N. 98: 178-190.

  9. Candido, E. B., Silva, L. M., Carvalho, A. T., Lamaita, R. M., Filho, R. M. P., Cota, B. D. C. V. and Silva-Filho, A. L. D. (2013). Immune response evaluation through determination of type 1, type 2, and type 17 patterns in patients with epithelial ovarian cancer. Reprod. Sci. 20: 828-837.

  10. Carter, B. H., Löest, C. A., Chen, L., Gilliam, G. G., Graham, B. C., Carroll, J. A., Collier, C. T. and Hallford, D. M. (2010). “Arginine supplementation does not alter nitrogen metabolism of beef steers during a lipopolysaccharide challenge.” Paper presented at the Proc. West Sect. Am. Soc. Anim. Sci., Denver, Colorado, 2010-07-11.

  11. Claerebout, E., Vercauteren, I., Geldhof, P., Olbrechts, A., Zarlenga, D. S., Goddeeris, B. M. and Vercruysse, J. (2005). Cytokine responses in immunized and non-immunized calves after ostertagia ostertagi infection. Parasite Immunol. 27: 325-331.

  12. Coskun, A. and Sen, I. (2012). Acute phase response and clinical changes in calves with lipopolysaccharide induced endotoxemia. Eurasian J. Vet. Sci. 28: 21-26.

  13. Coutinho, A., Gronowicz, E., MÖller, G. and Lemke, H. (1976). Polyclonal b cell activators. In Mitogens in Immunology, [edited by Oppenheim J J and Rosenstreich D L], 173-190: Academic Press.

  14. Gebru, E., Lee, J. S., Son, J. C., Yang, S. Y., Shin, S. A., Kim, B., Kim, M. K. and Park, S. C. (2010). Effect of probiotic, bacteriophage-, or organic acid-supplemented feeds or fermented soybean meal on the growth performance, acute-    phase response, and bacterial shedding of grower pigs challenged with salmonella enterica serotype typhimurium. J. Anim. Sci. 88: 3880-3886.

  15. Johnson, R. W. (1997). Inhibition of growth by pro-inflammatory cytokines: an integrated view. J. Anim. Sci. 75: 1244-    1255.

  16. Kim, M. H., Yun, C. H., Kim, G. R., Kol, J. Y., Lee, J. J. and Ha, J. K. (2011). Changes of immunoglobulins and lymphocyte subpopulations in peripheral blood from holstein calves challenged with escherichia coli lipopolysaccharide. Asian Austral. J. Anim. 24: 696-706.

  17. Kimball, S. R., Orellana, R. A., O’Connor, P. M., Suryawan, A., Bush, J. A., Nguyen, H. V., Thivierge, M. C., Jefferson, L. S. and Davis, T. A. (2003). Endotoxin induces differential regulation of mtor-dependent signaling in skeletal muscle and liver of neonatal pigs. Am. J. Physiol.-Endoc. M. 285: E637-E644.

  18. Klasing, K. C., Laurin, D. E., Peng, R. K. and Fry, D. M. (1987). Immunologically mediated growth depression in chicks: influence of feed intake, corticosterone and interleukin-1. J. Nutr. 117: 1629-1637.

  19. Obeidat, B. S., Cobb, C. J., Sellers, M. D., Pepper-Yowell, A. R., Earleywine, T. J. and Ballou, M. A. (2013). Plane of nutrition during the preweaning period but not the grower phase influences the neutrophil activity of holstein calves. J. Dairy Sci. 96: 7155-7166.

  20. Sartin, J. L., Whitlock, B. K. and Daniel, J. A. (2011). Triennial growth symposium: neural regulation of feed intake: modification by hormones, fasting, and disease. J. Anim. Sci. 89: 1991-2003.

  21. Sharma, S. K., Aditi and Haq, S. A. U. (2014). Influence of escherichia coli lipopolysaccharide induced fever on the plasma kinetics of pazufloxacin in buffalo calves. Indian J. Anim. SCI. 84: 166-169.

  22. Soberon, M. A., Liu, R. H. and Cherney, D. J. R. (2012). Short communication: antioxidant activity of calf milk replacers. J. Dairy Sci. 95: 2703-2706.

  23. Spurlock, M. E. (1997). Regulation of metabolism and growth during immune challenge: an overview of cytokine function. J. Anim. Sci. 75: 1773-1783.

  24. Steiger, M., Senn, M., Altreuther, G., Werling, D., Sutter, F., Kreuzer, M. and Langhans, W. (1999). Effect of a prolonged low-dose lipopolysaccharide infusion on feed intake and metabolism in heifers. J. Anim. Sci. 77: 2523-2532.

  25. Taylor, K. M., Carter, B. H., McDaniel, M. R., Chen, L., Duff, G. C., Hallford, D. M. and Löest, C. A. (2011). “Effects of animo acid supplementation on nitrogen metabolism and immune response of bottle-fed calves exposed to an endotoxin.” Paper presented at the Proc. West Sect. Am. Soc. Anim. Sci., Miles City Montana, 2011-07-21.

  26. Waggoner, J. W., Löest, C. A., Mathis, C. P., Hallford, D. M. and Petersen, M. K. (2009b). Effects of rumen-protected methionine supplementation and bacterial lipopolysaccharide infusion on nitrogen metabolism and hormonal responses of growing beef steers. J. Anim. Sci. 87: 681-692.

  27. Waggoner, J. W., Löest, C. A., Turner, J. L., Mathis, C. P. and Hallford, D. M. (2009a). Effects of dietary protein and bacterial lipopolysaccharide infusion on nitrogen metabolism and hormonal responses of growing beef steers. J. Anim. Sci. 87: 3656-3668.

  28. Waldron, M. R., Nishida, T., Nonnecke, B. J. and Overton, T. R. (2003). Effect of lipopolysaccharide on indices of peripheral and hepatic metabolism in lactating cows. J. Dairy Sci. 86: 3447-3459.

  29. Zanello, G., Berri, M., Dupont, J., Sizaret, P. Y., D’Inca, R., Salmon, H. and Meurens, F. (2011). Saccharomyces cerevisiae modulates immune gene expressions and inhibits etec-mediated erk1/2 and p38 signaling pathways in intestinal epithelial cells. PLoS One 6: e18573.

     
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