Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

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Research Article

Indian Journal of Animal Research, volume 52 issue 8 (august 2018) : 1141-1145

Effect of Ginkgo biloba extract on cognitive function and neurotransmitter levels in rats with vascular dementia

Jie Wang, Shan Mao, Jian Wang, Yuhuan Jiao, Xiangfeng Zhang, Yingxin Zhang, Zhenhuan Wang, Qinchang Zhang, Shaolin Li
1<p>Department of Neurology, Nanyang the First People&rsquo;s Hospital,&nbsp;Nanyang- 473 000, China.</p>
Cite article:- Wang Jie, Mao Shan, Wang Jian, Jiao Yuhuan, Zhang Xiangfeng, Zhang Yingxin, Wang Zhenhuan, Zhang Qinchang, Li Shaolin (2017). Effect of Ginkgo biloba extract on cognitive function and neurotransmitterlevels in rats with vascular dementia . Indian Journal of Animal Research. 52(8): 1141-1145. doi: 10.18805/ijar.v0iOF.8467.

ABSTRACT

This study aimed to investigate the effect of Ginkgo biloba extract on the cognitive function and neurotransmitter levels in rats with vascular dementia (VD) and its mechanism of action. 50 male Sprague Dawley rats were selected for this study, and the vascular dementia model was established by permanent occlusion of bilateral common carotid arteries of rats. Of which 40 rats were then divided into four groups (n=10):  vascular dementia group, low-dose, middle-dose and high-dose ginkgo biloba extract groups respectively; another 10 rats were allocated to sham operation group. Rats  in  low, middle and high dose groups were received 5, 10 and 20 mg/kg/d Ginkgo biloba extract via tail vein, respectively, while model group and sham group received an equal volume of normal saline. Morris water maze was used to evaluate the cognitive function of rats. After behavioral observation, these rats were sacrificed for detecting the level of acetylcholine (ACh), dopamine (DA) and 5-hydroxytryptamine (5-HT) in brain tissue. Ginkgo biloba extract can significantly improve the cognitive function of rats with vascular dementia, the mechanism may be correlated with the fact that the extract can obviously increase the levels of ACh, 5-HT and DA, as well as inhibit the activity of AChE.

REFERENCES


  1. Chen, J.Y., Yan, Z.W., Zhang, S.P. and Yin, Y.C. (2014). Influence of losartan on cognitive function improvement and cholinergic neuron of rats with vascular dementia. China Medical Herald 11: 10-13. 

  2. Gupta, S. and Sharma, B. (2014). Pharmacological modulation of I(1)-imidazoline and ±2-adrenoceptors in sub acute brain ischemia induced vascular dementia. Eur. J. Pharmacol. 723: 80-90. 

  3. Gupta, S., Singh, P., Sharma, B.M. and Sharma, B. (2015). Neuroprotective effects of agomelatine and vinpocetine against chronic cerebral hypoperfusion induced Vascular dementia. Curr. Neurovasc. Res. 12: 240-252.

  4. Habeych, M.E. and Castilla-Puentes, R. (2015). Comorbid medical conditions in vascular dementia: a matched case-control study. J. Nerv. Ment. Dis. 203: 604-608. 

  5. Ihl, R., Tribanek, M., Bachinskaya, N. and GOTADAY Study Group (2012). Efficacy and tolerability of a once daily formulation of Ginkgo biloba extract EGb 761® in Alzheimer’s disease and vascular dementia: results from a randomised controlled trial. Pharmacopsychiatry 45: 41-46.

  6. Li, Y., Zhao, J., Zhao, G.J., Chen, Y.H., et al. (2014). Experimental studies on effect of Yizhi Drink on learning and memory ability of vascular dementia rats and protection on hippocampal neuron. Chinese Journal of Traditional Medical Science and Technology 21: 377-378. 

  7. Saddoris, M.P., Cacciapaglia, F., Wightman, R.M. and Carelli, R.M. (2015). Differential Dopamine Release Dynamics in the Nucleus Accumbens Core and Shell Reveal Complementary Signals for Error Prediction and Incentive Motivation. J. Neuro sci. 35: 11572-11582. 

  8. Schmitz, M., Hermann, P., Oikonomou, P., Stoeck, K., et al. (2015). Cytokine profiles and the role of cellular prion protein in patients with vascular dementia and vascular encephalopathy. Neurobiol. Aging 36: 2597-2606.

  9. Shao, J.P., Wang, B.C., Chen, X. and Duan, C.R. (2003). Advanced Research on Pharmacology Value of the Extracts of Ginkgo Biloba Leaves. Journal of Chongqing University (Natural Science Edition) 26: 130-134. 

  10. Thomas, T., Miners, S. and Love, S. (2015). Post-mortem assessment of hypoperfusion of cerebral cortex in Alzheimer’s disease and vascular dementia. Brain 138: 1059-1069.

  11. Wan, P., Wang, S., Zhang, Y., Lv, J., et al. (2014). Involvement of dopamine D1 receptors of the hippocampal dentate gyrus in spatial learning and memory deficits in a rat model of vascular dementia. Pharmazie 69: 709-710.

  12. Wang, G.H., Wang, M., Guo, X.L., Liang, H., et al. (2012). Effect of Yindan Xinnaotong capsules on acetylcholinesterase level of the hippocampus in rats with vascular dementia and their behavioral changes. Chinese Journal of Neuromedicine 11: 590-593. 

  13. Wang, J., Chen, W. and Wang, Y. (2013). A ginkgo biloba extract promotes proliferation of endogenous neural stem cells in vascular dementia rats. Neural Regen Res. 8: 1655-1662. 

  14. Xue, L.P. and Long, Y.L. (2012). Effect of Ginkgo biloba extract on platelet aggregation of the patients with acute cerebral infarction. Chinese journal of integrative medicine on cardio/cerebrovascular disease 10: 1188-1189. 

  15. Yanf, S., Liang, Y.C., Yan, X.M., Zhang, L., et al. (2014). Effects of butylphthalide on cognitive function, apoptosis and p-p38MAPK expression in hippocampus of rat model of vascular dementia. Chinese Journal of Behavioral Medicine and Brain Science 23: 300-302.

  16. Zhang, H.Z., Liang, Y.L., Zhang, X.J., Zhang, C., et al. (2014). Effect of electroacupuncture intervention at different time-points of post-modeling on hippocampal monoamine neurotransmitter levels in mice with vascular dementia. Zhen Ci Yan Jiu 39: 142-147.

  17. Zhang, J., Guo, W., Tian, B., Sun, M., et al. (2015). Puerarin attenuates cognitive dysfunction and oxidative stress in vascular dementia rats induced by chronic ischemia. Int. J. Clin. Exp. Pathol. 8: 4695-4704.

  18. Zhang, X.Q., Li, P., Liu, W. and Chen, M. (2014). Effects of repetitive transcranial magnetic stimulation on the abilities of learning and memory and the cholinergic system of hippocampus formation in rats with vascular dementia. Neural Injury and Functional Reconstruction 9: 100-104
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