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Indian Journal of Animal Research

Effect on Healing Potential of Biosynthesized Silver Nanoparticles in Streptozotocin induce Diabetic Rat Wound Model

DOI: 10.18805/IJAR.B-4832    | Article Id: B-4832 | Page : 704-710
Citation :- Effect on Healing Potential of Biosynthesized Silver Nanoparticles in Streptozotocin induce Diabetic Rat Wound Model.Indian Journal of Animal Research.2022.(56):704-710
Y. Chandnani, M. Roy, C. Sannat, S. Roy, O.P. Mishra drmanjuroy117@gmail.com
Address : Department of Physiology and Biochemistry, College of Veterinary Science and Animal Husbandry, Anjora, Durg-491 001, Chhattisgarh, India.
Submitted Date : 18-11-2021
Accepted Date : 14-04-2022
First Online:

Abstract

Background: Diabetes mellitus is a complex chronic condition that results in hyperglycemic environment affecting the metabolism of proteins and lipids, promotes inflammation and delays wound healing.
Methods: A total of n=30 Wistar rats of either sex were divided into five groups with 6 animals in each. Diabetes mellitus was induced using streptozotocin @ 35 mg/kg body weight and excision wound model was developed in all the animals. Group I and Group II were considered as healthy and diabetic control group respectively. The wounds of Group III, IV and V were treated with topical application of Carica papaya synthesized silver nanoparticles @ 62.5 µg/ml, Carica papaya leafextract @ 31.25 mg/ml and 10% povidone iodine respectively. 
Result: Present study concluded that the characteristics of silver  nanaoparticles synthesized form C. papaya leaf extract make them suitable for the treatment of wound healing in diabetic subjects.

Keywords

Diabetes Extract Nanoparticles Plant Silver Wound

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