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Evaluation of the Efficacy of Mobility Plus® in the Management of Osteoarthritis and Joint Inflammation in Canines

DOI: 10.18805/IJAR.B-4521    | Article Id: B-4521 | Page : 1510-1514
Citation :- Evaluation of the Efficacy of Mobility Plus® in the Management of Osteoarthritis and Joint Inflammation in Canines.Indian Journal of Animal Research.2021.(55):1510-1514
K.C. Ashwath, G. Bhagwat Vishwanath, T. Santosh Kumar, Rangesh Paramesh dr.bhagwat@himalayawellness.com
Address : Himalaya Wellness Company, Makali, Bengaluru-562 162, Karnataka, India.
Submitted Date : 13-05-2021
Accepted Date : 4-08-2021

Abstract

Background: Joint health is very vital in canines. Immediate attention and diagnosis will help to prevent suffering in canines. This study was designed to evaluate the in vivo efficacy of the poly-herbal formulation Mobility Plus® for arthritis, inflammation and analgesic activities in canines.
Methods: A total of 18 client-owned dogs with a history of joint inflammation, hip dysplasia and arthritis were selected (n = 18) and supplemented with one tablet of Mobility Plus® daily until complete recovery. The changes in assessment parameters scores, viz. lameness score, joint mobility score, pain on palpation score, weight-bearing score and the overall clinical condition score were evaluated. The results revealed that lameness, joint mobility, pain and weight-bearing scores significantly (p<0.001) decreased in dogs as early as day 15; hence, the overall clinical condition score also decreased significantly (p<0.001) as early as day 15 after Mobility Plus® supplementation.
Result: Present study revealed that lameness, joint mobility, pain and weight-bearing scores significantly (p and lt; 0.001) decreased in dogs as early as day 15; hence, the overall clinical condition score also decreased significantly (p and lt; 0.001) as early as day 15 after Mobility Plus® supplementation. Supplementation of Mobility Plus® has antiarthritic and anti-inflammatory activities. Mobility Plus® could be recommended for the amelioration of joint inflammation and osteoarthritis conditions in canines.

Keywords

​Arthritis Joint mobility Lameness Pain Poly-herbal formulation

References

  1. Akhtar, N.M., Naseer, R., Farooqi, A.Z., Aziz, W., Nazir, M. (2004). Oral enzyme combination versus diclofenac in the treatment of osteoarthritis of the knee-a double-blind prospective randomized study. Clinical Rheumatology. 23: 410-415.
  2. Anderson, K.L., O’Neill, D.G., Brodbelt, D.C., Church, D.B., Meeson, R.L., Sargan, D., Summers, J.F., Zulch, H., Collins, L.M. (2018). Prevalence, duration and risk factors for appendicular osteoarthritis in a UK dog population under primary veterinary care. Scientific Reports. 8: 1-12.
  3. Aragon, C.L., Hofmeister, E.H., Budsberg, S.C. (2007). Systematic review of clinical trials of treatments for osteoarthritis in dogs. Journal of the American Veterinary Medical Association. 230: 514-521.
  4. Blotman, F., Maheu, E., Wulwik, A., Caspard, H., Lopez, A. (1997). Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial. Revue du Rhumatisme. 64: 825-834.
  5. Brien, S., Lewith, G., Walker, A., Hicks, S. M., Middleton, D. (2004). Bromelain as a treatment for osteoarthritis: A review of clinical studies. Evidence-Based Complementary and Alternative Medicine: eCAM. 1: 251-257.
  6. Buttgereit, F., Burmester, G.R., Simon, L.S. (2001). Gastrointestinal toxic side effects of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2-specific inhibitors. American Journal of Medicine. 110: 13S-19S.
  7. Cameron, M., Gagnier, J.J., Little, C.V., Parsons, T.J., Blümle, A., Chrubasik, S. (2009). Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Phytotherapy Research. 23: 1497-1515.
  8. Colitti, M., Gaspardo, B., Della Pria, A., Scaini, C., Stefanon, B. (2012). Transcriptome modification of white blood cells after dietary administration of curcumin and non-steroidal anti-inflammatory drug in osteoarthritic affected dogs. Veterinary Immunology and Immunopathology. 147: 136-146.
  9. Curry, S.L., Cogar, S.M., Cook, J.L. (2005). Nonsteroidal anti- inflammatory drugs: A review. Journal of the American Animal Hospital Association. 41: 298-309.
  10. Engwerda, C.R. andrew, D., Ladhams, A., Mynott, T.L. (2001). Bromelain modulates T cell and B cell immune responses in vitro and in vivo. Cellular Immunology. 210: 66-75.
  11. Ernst, E. (2003). Avocado-soybean unsaponifiables (ASU) for osteoarthritis-a systematic review. Clinical Rheumatology. 22: 285-288.
  12. Gu, X., Wu, H., Fu, P. (2013). Allicin attenuates inflammation and suppresses HLA-B27 protein expression in ankylosing spondylitis mice. BioMed Research International. 2013: 171573.
  13. Hassan, N.A., Karunakaran, R., Uma, S.A. (2017). Anti-inflammatory effect of Zingiber officinale on Sprague Dawley rats. Asian Journal of Pharmaceutical and Clinical Research. 10: 1-3.
  14. Henrotin, Y., Kurz, B., Aigner, T. (2005). Oxygen and reactive oxygen species in cartilage degradation: Friends or foes? Osteoarthritis and Cartilage. 13: 643-654.
  15. Hobauer, R., Frass, M., Gmeiner, B., Kaye, A.D., Frost, E.A. (2000). Garlic extract (Allium sativum) reduces migration of neutrophils through endothelial cell monolayers. Middle East Journal of Anaesthesiology. 15: 649-658.
  16. Innes, J.F., Fuller, C.J., Grover, E.R., Kelly, A.L., Burn, J.F. (2003). Randomised, double-blind, placebo controlled parallel group study of P54FP for the treatment of dogs with osteoarthritis. Veterinary Record. 152: 457-460.
  17. Jeong, Y.Y., Ryu, J.H., Shin, J.H., Kang, M.J., Kang, J.R., Han, J., Kang, D. (2016). Comparison of anti-oxidant and anti- inflammatory effects between fresh and aged black garlic extracts. Molecules. 21: 430.
  18. Kargutkar, S., Brijesh, S. (2016). Anti-rheumatic activity of Ananas comosus fruit peel extract in a complete Freund’s adjuvant rat model. Pharmaceutical Biology. 54: 2616-2622.
  19. Kargutkar, S., Brijesh, S. (2018). Anti-inflammatory evaluation and characterization of leaf extract of Ananas comosus. Inflammopharmacology. 26: 469-477.
  20. Khanna, D., Sethi, G., Ahn, K.S., Pandey, M.K., Kunnumakkara, A.B., Sung, B., Aggarwal, A., Aggarwal, B.B. (2007). Natural products as a gold mine for arthritis treatment. Current Opinion in Pharmacology. 7: 344-351.
  21. Maheu, E., Cadet, C., Marty, M., Moyse, D., Kerloch, I., Coste, P., Dougados, M., Mazières, B., Spector, T.D., Halhol, H., Grouin, J.M. (2014). Randomised, controlled trial of avocado-soybean unsaponifiable (Piascledine) effect on structure modification in hip osteoarthritis: The ERADIAS study. Annals of the Rheumatic Diseases. 73: 376-384.
  22. Maurer, H.R. (2001). Bromelain: Biochemistry, pharmacology and medical use. Cellular and Molecular Life Sciences: CMLS. 58: 1234-1245.
  23. McCarthy, G., O’Donovan, J., Jones, B., Jones, B., McAllister, H., Seed. M., Mooney, C. (2007). Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine /chondroitin sulfate for the treatment of dogs with osteoarthritis. Veterinary Journal. 174: 54-61.
  24. Mojcik, C.F., Shevach, E.M. (1997). Adhesion molecules. A rheumatologic perspective. Arthritis and Rheumatism: Official Journal of the American College of Rheumatology. 40: 991-1004.
  25. Paster, E.R., LaFond, E., Biery, D.N., et al. (2005). Estimates of prevalence of hip dysplasia in Golden Retrievers and Rottweilers and the influence of bias on published prevalence figures. Journal of the American Veterinary Medical Association. 226: 387-392.
  26. Pavan, R., Jain, S., Kumar, A. (2012). Properties and therapeutic application of bromelain: A review. Biotechnology Research International. 1-5.
  27. Schlesinger, N. (2004). Management of acute and chronic gouty arthritis: Present state-of-the-art. Drugs. 64: 2399-2416.
  28. Secor, Jr., E.R., Carson IV, W.F., Cloutier, M.M., Guernsey, L.A., Schramm, C.M., Wu, C.A., Thrall, R.S. (2005). Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease. Cellular Immunology. 237: 68-75.
  29. Sinal, C.J., Gonzalez, F.J. (2002). Guggulsterone: An old approach to a new problem. Trends in Endocrinology and Metabolism. 13: 275-276.
  30. Singh, B.B., Mishra, L.C., Vinjamury, S.P., Aquilina, N., Singh, V.J., Shepard, N. (2003). The effectiveness of Commiphora mukul for osteoarthritis of the knee: An outcomes study. Alternative Therapies in Health and Medicine. 9: 74-79.
  31. Smith, G.K., Paster, E.R., Powers, M.Y., Lawler, D.F., Biery, D.N., Shofer, F.S., McKelvie, P.J., Kealy, R.D. (2006). Lifelong diet restriction and radiographic evidence of osteoarthritis of the hip joint in dogs. Journal of the American Veterinary Medical Association. 229: 690-693.
  32. Tanwar, A., Pallavi, T., Raman, C., Haider, K. (2015). Curative Remedies for rheumatoid arthritis: Herbal Informatics Approach for rational based selection of Natural Plant Products. Proceedings of the India International Science Festival Young Scientists’ Meet Department of Science and Technology p. 143. Government of India.
  33. Tjendraputra, E., Tran, V.H., Liu-Brennan, D., Roufogalis, B.D., Duke, C.C. (2001). Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorganic Chemistry. 29: 156-163.
  34. Urizar, N.L., Moore, D.D. (2003). Gugulipid: A natural cholesterol- lowering agent. Annual Review of Nutrition. 23: 303-313.
  35. Verma, S.K., Singh, M., Jain, P., Bordia, A. (2004). Protective effect of ginger, Zingiber officinale Rosc on experimental atherosclerosis in rabbits. Indian Journal of Experimental Biology. 42: 736-738.

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