Loading...

Therapeutic Efficacy of Garlic (Allium sativum), Turmeric (Curcuma longa) and Eucalyptus (Eucalyptus globules) Extracts in the Treatment of Bovine Endometritis

DOI: 10.18805/IJAR.B-4492    | Article Id: B-4492 | Page : 904-908
Citation :- Therapeutic Efficacy of Garlic (Allium sativum), Turmeric (Curcuma longa) and Eucalyptus (Eucalyptus globules) Extracts in the Treatment of Bovine Endometritis.Indian Journal of Animal Research.2022.(56):904-908
D. Gopikrishnan, M. Selvaraju, M. Palanisamy, M. Periyannan, K. Ravikumar, K. Senthilkumar drmselvaraju1969@gmail.com
Address : Department of Veterinary Gynaecology and Obstetrics, Veterinary College and Research Institute, Tamil Nadu Veterinary and Animal Sciences University, Namakkal-637 002, Tamil Nadu, India.
Submitted Date : 21-04-2021
Accepted Date : 10-09-2021

Abstract

Background: Endometritis is one of the major causes of subfertility in bovines. The present study was conducted to evaluate the therapeutic efficacy of ethanolic extracts of garlic, turmeric and eucalyptus in the treatment of bovine endometritic as an alternative to antibiotics. 
Methods: Forty crossbred cows affected with endometritis were equally divided into 4 groups. Group I (control) cows were treated intrauterinely (i.u) with streptopenicillin 2.5 g + 30 ml normal saline for 3 days and group II, III and IV cows were treated (i.u) with 30-40 ml of ethanolic extract of garlic, turmeric and eucalyptus for 3 consecutive days. The animals were inseminated artificially on subsequent estrus after the treatment. 
Result: Bacterial count in uterine flushing declined significantly after treatment in all the four groups. The percentage of reduction in bacterial count was higher in garlic treated cows than in control and other treatment groups. A significant increase in percentage of PMNs was found after treatment in all the groups. The overall conception rate was 40% in control group, 50% in group II and 30% in group III and IV. It was concluded that ethanolic extract of garlic for the treatment of endometritis resulted in better conception rate and significantly higher percentage reduction of bacterial load than other treatment and control groups.

Keywords

Bovine Endometritis Eucalyptus Garlic Turmeric

References

  1. Abdul-Hafeez, M.M., Abdul-Kadder, H.A. and Sayed, A.M. (2019). Intrauterine honey infusion in Holstein Frisian cows with purulent endometritis. International Journal of Complementary and Alternative Medicine. 12(1): 53-57.
  2. Alagar, S., Selvaraju, M. and Ezakial Napolean, R. (2018). Phytotherapy (Garlic-Allium sativum) in endometritis affected buffalo. International Journal of Current Microbiology and Applied Sciences. 7(03): 762-765.
  3. Bhardwaz, A., Nema, S.P., Sudarshan, K., Chabbra D., Shukla, S. and Madhwani, R. (2018). Effect of ciprofloxacin on recovery and conception rate in infectious repeat breeder crossbred cows. Indian Journal of Veterinary Science and Biotechnology. 14(1): 71-74. 
  4. Chung, K.S., Kang, S.Y. and Kim, J.Y. (2003). The antibacterial activity of garlic juice against pathogenic bacteria and lactic acid bacteria. Korean Journal of Microbiology and Biotechnology. 31(1): 32-35.
  5. Cunha, B.A., (2001). Antibiotics side effects. Medical Clinics of North America. 85: 149-185. 
  6. Dhaliwal, G.S., Murray, R.D. and Woldehiwet, Z. (2001). Some aspects of immunology of the bovine uterus related to treatments for endometritis. Animal Reproduction Science. 67: 135-152. 
  7. Fratini, F., Mancini, S., Turchi, B., Friscia, E., Pistelli, L., Giusti, G. and Cerri, D. (2017). A novel interpretation of the fractional inhibitory concentration index: The case Origanum vulgare L. and Leptospermum scoparium J.R. et G. Forst essential oils against Staphylococcus aureus strains. Microbiological Research. 195: 11-17. 
  8. Gautam, G., Nakao, T., Yusuf, M. and Koike, K. (2009). Prevalence of endometritis during the postpartum period and its impact on subsequent productive performance in two Japanese dairy herds. Animal Reproduction Science. 116: 175-187.
  9. Hayat, U., Jilani, M.I., Rehman, R. and Nadeem, F. (2015). A Review on Eucalyptus globulus: A New Perspective in Therapeutics. International Journal of Chemical and Biochemical Sciences. 8: 85-91. 
  10. Hossam, M.A. (2008). Antibacterial, antifungal and anticancer activities of volatile oils and extracts from stems, leaves and flowers of Eucalyptus sideroxylon and Eucalyptus torquata. Cancer Biology and Therapy. 7(3): 399-403.
  11. Jagetia, G.C. and Aggarwal, B.B. (2007). “Spacingup” of the immune system by curcumin. Journal of Clinical Immunology. 27(1): 19-35. 
  12. Kumar, A. (2013). Evaluation of immunomodulatory and therapeutic efficacy of turmeric (Curcuma longa) neem (Azadirachta indica) and garlic (Allium sativum) on endometritis in repeat breeding crossbred cows. M.V.Sc. Thesis, G.B. Pant University of Agriculture and Technology, Pantnagar, India.
  13. Kumar, H., Shooshan, N., Barman, P. and Yadav, M.C. (2009). Administration of herbal antimicrobials recovers the endometritis in buffaloes. Indian Journal of Animal Sciences. 79: 679-690. 
  14. Kumar, H., Shooshan, N., Das, R.S. and Garg, A.D. (2013). Effect of treatment of immunomodulation on recovery and conception rate in endometritic buffaloes. Indian Journal of Animal Sciences. 83: 129-132.
  15. Kumar, P.R., Sunith, R. and Rajanna, R. (2020). Bovine endometritis: A review article. The Pharma Innovation Journal. 9(2): 55-58.
  16. Kumar, R. (2016). Studies on the immunomodulatory and therapeutic efficacy of ashwagandha (Withania somnifera), garlic (Allium sativum) and turmeric (Curcuma longa) on endometritic repeat breeding crossbred cows. A Ph.D. thesis submitted to the Birsa Agricultural University, Kanke, Ranchi, Jharkhand. 
  17. Kyo, E., Uda, N., Suzuki, A., Kakimoto, M., Ushigina, M., Kasuga, S. and Itakura, Y. (1998). Immunomodulation and antitumour activities of aged garlic extract. Phytomedicine. 5(4): 259- 267. 
  18. Mahour, S.S., Nema, S.P., Aich, R., Karmore, S.K., Jatav, G.P. and Kurechiya, N. (2021). Use of ethanolic herbal extracts and ciprofloxacin for the treatment of subclinical endometritis in crossbred cows. International Journal of Livestock Research. 11(1): 177-183.
  19. Meriga, B., Mopuri, R. and Murali Krishna, T. (2012). Insecticidal, antimicrobial and antioxidant activities of bulb extracts of Allium sativum. Asian Pacific Journal of Tropical Medicine. 5(5): 391-395. 
  20. Palanisamy, M., Ezakial Napolean, R., Selvaraju, M., Krishnakumar, K., Malmarugan, S., Balasubramaniam, G.A. and Manokaran, S. (2015). Effect of intrauterine infusion of immunomodulators on cytology of uterus in endometritis affected cows. Indian Veterinary Journal. 92(12): 31-34.
  21. Parmar, K.H. (2021). Endometritis in Bovine: A Review. Agricultural Reviews. 42(3): 342-347. DOI: 10.18805/ag.R-2038.
  22. Sadanandan, B., Prerna, L., Humtsoe, H. and Mishra, A. (2014). Antibacterial activity of garlic against Bacillus subtilis. International Journal of Applied Biotechnology and Biochemistry. 2: 107-119. 
  23. Sarkar, P., Kumar, H., Rawat, M., Varshney, V.P., Goswarni, T.K., Yadav, M.C. and Srivastava, S.K. (2006). Effect of administration of Garlic extract and PGF2 alpha on hormonal change and recovery in endometritis cow. Asian Australian Journal of Animal Science. 19(7): 964-969. 
  24. Selvaraju, M., Vijay Anand, K.R., Parthiban, R., Micheal Raj, P., Kathiresan, D. and Murali Manohar, B. (2003). Effect of ethylene diamine tetra acetic acid (EDTA) plus tris adjuvant to streptopenicillin in the treatment of clinical endometritis in cows. Indian Journal of Animal Sciences. 73(3): 231-234.
  25. Selvaraju, M., Veerapandian,C., Kathiresan. D., Chandrahasan, C. (2005). Incidence of bovine reproductive disorders. Indian Veterinary Journal. 82: 556.
  26. Shabunin, S., Bondarev, I., Mikhalev, I, Tolkachev, I. and Stekolnikov, A. (2020). Problem of chronic endometritis in cows and ways to solve it. BIO Web of Conferences. 17: 00101.
  27. Sheldon, I.M., Lewis, G.S., LeBlanc, S. and Gilbert, R.O. (2006). Defining postpartum uterine disease in cattle. Theriogenology. 65: 1516-1530. 
  28. Singh, S. (2016). Phytotherapeutic measures for endometritis in crossbred cows. M.V.Sc thesis. Nanaji Deshmukh Veterinary Science University, Jabalpur, India.
  29. Viswanathan, V., Phadatare, A.G. and Mukne, A. (2014). Antimycobacterial and antibacterial activity of Allium sativum bulbs. Indian Journal of Pharmaceuticals Sciences. 76(3): 256-261.

Global Footprints