Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

  • Print ISSN 0367-6722

  • Online ISSN 0976-0555

  • NAAS Rating 6.50

  • SJR 0.263

  • Impact Factor 0.5 (2023)

Frequency :
Monthly (January, February, March, April, May, June, July, August, September, October, November and December)
Indexing Services :
Science Citation Index Expanded, BIOSIS Preview, ISI Citation Index, Biological Abstracts, Scopus, AGRICOLA, Google Scholar, CrossRef, CAB Abstracting Journals, Chemical Abstracts, Indian Science Abstracts, EBSCO Indexing Services, Index Copernicus
Submit

Research Article

Indian Journal of Animal Research, volume 51 issue 4 (august 2017) : 654-659

Thermally induced stress revealed behavioral, hormonal and histological disturbances in mice model 

Shahar Bano Memon, Li Lian, Javaid Ali Gadahi, Wang Genlin
1<p>College of Animal Science and Technology,&nbsp;Nanjing Agricultural University, Nanjing 210095, PR China.</p>
Cite article:- Memon Bano Shahar, Lian Li, Gadahi Ali Javaid, Genlin Wang (2016). Thermally induced stress revealed behavioral, hormonaland histological disturbances in mice model . Indian Journal of Animal Research. 51(4): 654-659. doi: 10.18805/ijar.11465.

ABSTRACT

Behavioral, hormonal and histological changes caused by heat stress at 30 and 40oC were studied in mice model. As a result, obnoxious activities like restlessness and hyperactivity were observed. Rectal temperature was significantly increased at 40oC as well as the increase in water intake, whereas, the feed intake remained consistent. Body weight significantly decreased at 40oC. Serum testosterone has shown a decrease in both groups. At day 7 of the treatment, low levels of growth hormone were recorded whereas no significant difference was recorded at day 15. Adrenocorticotropic hormone level was significantly decreased in both groups at day 7. Shrinking of the seminiferous tubules with irregular appearance containing less spermatozoa was also observed at 40oC. Testicular degeneration and atrophy of leydig cells were also observed. Finally, we concluded that heat stress adversely affects the male reproductive functions along with hormonal imbalances and decline in the spermatogenesis. 

REFERENCES


  1. Agrawal, S. and Gupta, D. (2013). Behavioral changes in albino rats due to repetitive heat stress of moderate level. Int J Med Sci Public Health, 2: 650-653.

  2. Aggarwal, A. and Upadhyay, R. (2013). Heat stress and hormones. In: Heat stress and animal productivity. Springer: pp: 27-51.

  3. Bancroft, J.D. and Gamble, M. (2008). Theory and Practice of Histological Techniques. Elsevier Health Sciences.

  4. Banks, S., King, S.A., Irvine, D.S. and Saunders, P.T.K. (2005). Impact of a mild scrotal heat stress on DNA integrity in murine spermatozoa. Reproduction, 129: 505-514. 

  5. Chen, M., Wang, Z., Zhan, M., Liu, R., Nie, A., Wang, J., Ning, G. and Ma, Q. (2014). Adiponectin regulates acth secretion and the hpaa in an ampk-dependent manner in pituitary corticotroph cells. Mol Cell Endocrinol, 383: 118-    125. 

  6. Collier, R.J., Dahl, G.E. and VanBaale, M.J. (2006). Major advances associated with environmental effects on dairy cattle. Journal of dairy science, 89: 1244-1253. 

  7. Djordjevic, J., Cvijic, G. and Davidovic, V. (2003). Different activation of acth and corticosterone release in response to various stressors in rats. Physiological research / Academia Scientiarum Bohemoslovaca, 52: 67-72.

  8. Durairajanayagam, D., Agarwal, A. and Ong, C. (2015). Causes, effects and molecular mechanisms of testicular heat stress. Reproductive biomedicine online, 30: 14-27. 

  9. Epstein, Y. and Roberts, W.O. (2011). The pathopysiology of heat stroke: An integrative view of the final common pathway. Scandinavian journal of medicine & science in sports, 21: 742-748. 

  10. Hansen, P.J., (2009). Effects of heat stress on mammalian reproduction. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 364: 3341-3350. 

  11. Jung, A. and Schuppe, H.C. (2007). Influence of genital heat stress on semen quality in humans. Andrologia, 39: 203-215. 

  12. Keim, S.M., Guisto, J.A. and Sullivan, Jr, J.B., (2002). Environmental thermal stress. Annals of agricultural and environmental medicine : AAEM, 9: 1-15.

  13. Lim, C.L., Wilson, G., Brown, L., Coombes, J.S. and Mackinnon, L.T. (2007). Pre-existing inflammatory state compromises heat tolerance in rats exposed to heat stress. American journal of physiology. Regulatory, integrative and comparative physiology, 292: R186-194. 

  14. Lin, C., Shin, D.G., Park, S.G., Chu, S.B., Gwon, L.W., Lee, J.G., Yon, J.M., Baek, I.J. and Nam, S.Y. (2015). Curcumin dose-dependently improves spermatogenic disorders induced by scrotal heat stress in mice. Food & function, 6: 3770-7

  15. Lue, Y.H., Lasley, B.L., Laughlin, L.S., Swerdloff, R.S., Hikim, A.P., Leung, A., Overstreet, J.W. and Wang, C. (2002). Mild testicular hyperthermia induces profound transitional spermatogenic suppression through increased germ cell apoptosis in adult cynomolgus monkeys (macaca fascicularis). Journal of andrology, 23: 799-805.

  16. Maya-Soriano, M.J., Taberner, E., Sabes-Alsina, M., Ramon, J., Rafel, O., Tusell, L., Piles, M. and Lopez-Bejar, M. (2015). Daily exposure to summer temperatures affects the motile subpopulation structure of epididymal sperm cells but not male fertility in an in vivo rabbit model. Theriogenology. 84: 384-9

  17. Mesquita, A.R., Tavares, H.B., Silva, R. and Sousa, N. (2006). Febrile convulsions in developing rats induce a hyperanxious phenotype later in life. Epilepsy & behavior : E&B, 9: 401-406. 

  18. Mete, F., Kilic, E., Somay, A. and Yilmaz, B. (2012). Effects of heat stress on endocrine functions & behaviour in the pre-    pubertal rat. The Indian journal of medical research, 135: 233-239.

  19. Papadimitriou, A. and Priftis, K.N. (2009). Regulation of the hypothalamic-pituitary-adrenal axis. Neuroimmunomodulation, 16: 265-271.

  20. Paul, C., Teng, S. and Saunders, P.T. (2009). A single, mild, transient scrotal heat stress causes hypoxia and oxidative stress in mouse testes, which induces germ cell death. Biology of reproduction, 80: 913-919. 

  21. Pérez-Crespo, M., Pintado, B. and Gutiérrez-Adán, A. (2008). Scrotal heat stress effects on sperm viability, sperm DNA integrity, and the offspring sex ratio in mice. Molecular Reproduction and Development, 75: 40-47.

  22. Rajaseger, G., Lim, C.L., Wui, L.K., Saravanan, P., Tang, K., Gopalakrishnakone, P., Pen-huat, Y.E., Lu, J. and Shabbir, M.M. (2009). A study on the differential protein profiles in liver cells of heat stress rats with and without turpentine treatment. Proteome science, 7: 1. 

  23. Rockett, J.C., Mapp, F.L., Garges, J.B., Luft, J.C., Mori, C. and Dix, D.J. (2001). Effects of hyperthermia on spermatogenesis, apoptosis, gene expression, and fertility in adult male mice. Biology of reproduction, 65: 229-239.

  24. Schwalm, A., Gauly, M., Erhardt, G. and Bergmann, M. (2007). Changes in testicular histology and sperm quality in llamas (lama glama), following exposure to high ambient temperature. Theriogenology, 67: 1316-1323. 

  25. Serafini, L., Hann, J.B., Kültz, D. and Tomanek, L. (2011). The proteomic response of sea squirts (genus ciona) to acute heat stress: A global perspective on the thermal stability of proteins. Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 6: 322-334. 

  26. Sieck, G.C., (2002). Molecular biology of thermoregulation. Journal of applied physiology (Bethesda, Md. : 1985), 92: 1365-1366. 

  27. Somero, G.N., (2010). The physiology of climate change: How potentials for acclimatization and genetic adaptation will determine ‘winners’ and ‘losers’. The Journal of experimental biology, 213: 912-920. 

  28. Stallings, J.D., Ippolito, D.L., Rakesh, V., Baer, C.E., Dennis, W.E., Helwig, B.G., Jackson, D.A., Leon, L.R., Lewis, J.A. and Reifman, J. (2014). Patterns of gene expression associated with recovery and injury in heat-stressed rats. BMC genomics, 15: 1058. 

  29. Yaeram, J., Setchell, B. and Maddocks, S. (2006). Effect of heat stress on the fertility of male mice in vivo and in vitro. Reproduction, Fertility and Development, 18: 647-653.

  30. Yaeram, J., Setchell, B.P. and Maddocks, S. (2006). Effect of heat stress on the fertility of male mice in vivo and in vitro. Reproduction, Fertility and Development, 18: 647-653. 

     
Reviewed By

Download Article
In this Article
    Contact us
    Follow us

    Editorial Board

    View all (0)