Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

  • Print ISSN 0367-6722

  • Online ISSN 0976-0555

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Indian Journal of Animal Research, volume 51 issue 4 (august 2017) : 687-693

Effect of long term supplementation with dietary lipids on growth and fatty acid composition of rabbit’s brain

Doha Mustafa Al Nouri, Shaista Arzoo
1<p>Department of Food and Nutrition Sciences,&nbsp;King Saud University, Riyadh-11495, Kingdom of Saudi Arabia.</p>
Cite article:- Nouri Al Mustafa Doha, Arzoo Shaista (2017). Effect of long term supplementation with dietary lipids ongrowth and fatty acid composition of rabbit&rsquo;s brain . Indian Journal of Animal Research. 51(4): 687-693. doi: 10.18805/ijar.v0iOF.7262.

The purpose of this study was to investigate the effect of long-term supplementation with dietary lipids on growth and fatty acid composition of rabbit’s brain. Soybean oil, fish oil, sesame oil, docosahexaenoic acid and arachidonic acid were fed to weanling rabbits for 100 days. The rabbits were decapitated and brain sample was removed, homogenized and fatty acid concentration was measured by gas chromatography. Dietary lipids had a distinct effect on growth rate only in males. Rabbits fed the fish oil diet showed the highest total w-3 fatty acids and lowest w-6/w-3 ratios. Rabbits fed the DHA diet had highest total saturated fatty acids and lowest values of total MUFA, total PUFA, total w-6, and total w-3 in females. This study shows that w-6/w-3 ratios have tremendous effect on the fatty acid composition of rabbit’s brain. Effect of treatment was not significant among different gender except for total saturated, ARA, C20:1 and C16:0. FO, DHA and DHA+ARA groups showed the w-6/w-3 ratios within the recommended range. This study shows that fatty acid composition of brain can be modulated by dietary lipids and long-term supplementation of dietary lipids especially fish oil (FO) has very good effect on the fatty acid composition of  rabbit’s brain. 

  1. Adibhatla, R.M. and Hatcher, J.F. (2007). Role of Lipids in Brain Injury and Diseases. Future Lipidol. 2: 403–422.

  2. Anding, R.H. and Hwang, D.H. (1986). Effects of dietary linolenate on the fatty acid composition of brain lipids in rats. Lipids. 21:697-701.

  3. Angulo-Guerrero, O. and Oliart, R.R. (1998). Effects of dietary polyunsaturated fatty acids on rat brain plasma membrane fatty acid composition. Arch Latinoam Nutr. 48:287–92. 

  4. Barjanti, V., Battino, M., Baracca, A., Cavazzoni, M,, Cocchi, M., Noble, R., Maranesi, M., Turchetto, E. and Lenaz, G. (1994). The effect of dietary lipid changes on the fatty acid composition and function of liver heart and brain mitochondria in the rat at different ages. Brit J Nutr.71: 193-202.

  5. Bligh, E.G. and Dyer, W.J. (1959). A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 37: 911-917.

  6. Croft, K.D., Codde, J.P., Barden, A., Vandongen, R. and Beilin, L.J. (1988). Effect of dietary fish oils on the formation of leukotrienes B4 and B5, thromboxane and platelet activating factor by rat leukocytes. Clin Exp Pharmacol Physiol.15: 517-525.

  7. Enser, M., Richardson, R.I., Wood, J.D., Gill, B.P. and Sheard, P.R. (2000). Feeding linseed to increase the n-3 PUFA of fork: fatty acid composition of muscle, adipose tissue, liver and sausages. Meat Sci. 55: 201-212.

  8. Fernandez, C., Cobos, A. and Fraga, M.J. (1994). The effect of fat inclusion on diet digestibility in growing rabbits. J Animal Sci. 72:1508-1515.

  9. Fernstrom, J.D. (2000). Can nutrient supplements modify brain function? Am J Clin Nutr. 71:1669–1675.

  10. Folch, J., Lees, M. and Stanley, S. (1957). A simple method for the isolation and purification of total lipids from animal tissue. J Biol Chem. 226: 497-509.

  11. Galli, C., Trzeciak, H.I. and Paoletti, R. (1971). Effects of dietary fatty acids on the fatty acid composition of brain ethanolamine phosphoglyceride: reciprocal replacement of n-6 and n-3 polyunsaturated fatty acids. Biochim Biophys Acta. 248: 449-45. 

  12. Innis, S.M. (2000). Essential fatty acids in infant nutrition: lessons and limitations from animal studies in relation to studies on infant fatty acid requirements. Am J Clin Nutr.71: S238:S244.

  13. Innis, S.M. (2007). Dietary (n-3) fatty acids and brain development. J. Nutr.137:855-9.

  14. Mitchaothai, J., Yuangklang, C., Wittayakun, S., Vasupen, K., Wongsutthavas, S., Srenanul, P., Hovenier, R., Everts, H. and Beynen, A.C. (2007). Effect of dietary fat type on meat quality and fatty acid composition of various tissues in growing finishing swine. Meat Sci.76: 95-101.

  15. Molnar, T., Biro, J., Hancz, C., Romvari, R., Varga, D., Horn, P. and Szabo, A. (2012). Fatty acid profile of fillet, liver and mesenteric fat in tilpila (Oreochromis niloticus) fed vegetable oil supplementation in the finishing period of fattening. Archiv furTierzucht. 55: 194-205.

  16. Nettleton, J.A. (2008). Concerning PUFA in fish. J Am Diet Assoc. 108: 1830-1831. 

  17. Oliver, M.A., Guerrero, L., Diaz, I., Gispert., M., Pla, M. and Blasco, A. (1997). The effect of fat enriched diets on the perirenal fat quality and sensory characteristics of meat from rabbit. Meat Sci.47: 95-103.

  18. Reeves, P.G. (1997). Components of the AIN-93 diets as improvements in the AIN-76A diet. J. Nutr. 127: S838-S841.

  19. Siddiqui, R.A., Harvey, K.A. and Zaloga, G.P. (2008). Modulation of enzymatic activities by n-3 polyunsaturated fatty acids to support cardiovascular health. J Nutr Biochem.19: 417–437.

  20. Sinclair, A.J. (1975). Long-chain polyunsaturated fatty acids in the mammalian brain. Proc Nutr Soc. 34:287–91. 

  21. Sirosis, I., Cheung, A.M. and Ward, W.E. (2003). Biochemical bone strength and bone mass in young male and female rats fed a fish oil diet. Prostaglandins Leukot Essent Fatty Acids. 68: 415-421.

  22. Suzuki, H., Park, S.J., Tamura, M. and Ando, S. (1998). Effect of the long-term feeding of dietary lipids on the learning ability, fatty acid composition of brain stem phospholipids and synaptic membrane fluidity in adult mice: a comparison of sardine oil diet with palm oil diet. Mech Ageing Dev. 101: 119–128.

  23. Wainwright, P.E. (2002). Dietary essential fatty acids and brain function: A developmental perspective on mechanisms. Proc Nutr Soc. 61:61–69.


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