- Agarwal, V., Bell, G.W., Nam, J.W. and Bartel, D.P. (2015). Predicting effective microRNA target sites in mammalian mRNAs. https://doi.org/10.7554/eLife.05005.
- Bartel, D.P. (2004). MicroRNAs. Cell. 116(2): 281-297. https://doi. org/10.1016/S0092-8674(04)00045-5.
- Bartel, D.P. (2009). MicroRNAs: Target Recognition and Regulatory Functions. Cell 136(2): 215-233. https://doi.org/10.1016/j.cell.2009.01.002.
- Beall, C.M., Cavalleri, G.L., Deng, L., Elston, R.C., Gao, Y., et al. (2010). Natural selection on EPAS1 (HIF2) associated with low hemoglobin concentration in Tibetan highlanders. Proceedings of the National Academy of Sciences. 107(25): 11459-11464.https://doi.org/10.1073/pnas.1002443107
- Bhardwaj, S. (2020). Genome wide association studies on indigenous cattle for cold adaptation. M.V. Sc. Thesis submitted to Deemed University, ICAR-NDRI, Karnal, India.
- Bigham, A.W. and Lee, F.S. (2014). Human high-altitude adaptation: Forward genetics meets the HIF pathway. Genes and Development. 28(20): 2189-2204. https://doi.org/10.1101/gad.250167.114.
- Cioffi, C.L., Qin Liu, X., Kosinski, P.A., Garay, M. and Bowen, B.R. (2003). Differential regulation of HIF-1á prolyl-4-hydroxylase genes by hypoxia in human cardiovascular cells. Biochemical and Biophysical Research Communications. 303(3): 947-953. https://doi.org/10.1016/S0006-291X(03)00453-4.
- Ding, Y., Niu, H., Yang, H., Sun, P., Chen, Y., Duan, M., Xu, D., Xu, J. and Jin, T. (2015). EGLN2 and RNF150 genetic variants are associated with chronic obstructive pulmonary disease risk in the Chinese population. International Journal of Chronic Obstructive Pulmonary Disease. 10(1): 145-151. https://doi.org/10.2147/COPD.S73031.
- Giaccia, A., Siim, B.G. and Johnson, R.S. (2003). HIF-1 as a target for drug development. Nature Reviews Drug Discovery. 2(10): 803-811. https://doi.org/10.1038/nrd1199.
- Huerta-Sánchez, E., Jin, X., Asan, Bianba, Z., Peter, B.M., Vinckenbosch, N., Liang, Y., Yi, X., He, M., Somel, M., Ni, P., Wang, B., Ou, X., Huasang, Luosang, J., Cuo, Z.X.P., Li, K., Gao, G., Yin, Y., Nielsen, R. (2014). Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA. Nature. 512(7513): 194-197. https://doi.org/10.1038/nature13408.
- Ivan, M., Haberberger, T., Gervasi, D.C., Michelson, K.S., Gunzler, V., Kondo, K., Yang, H., Sorokina, I., Conaway, R.C., Conaway, J.W. and Kaelin, W.G. (2002). Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proceedings of the National Academy of Sciences. 99(21): 13459-13464. https://doi.org/10.1073/pnas.192342099.
- Ivan, M., Kondo, K., Yang, H., Kim, W., Valiando, J., Ohh, M., Salic, A., Asara, J. M., Lane, W. S. and Kaelin, W.G. (2001). HIF alpha Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O2 Sensing. Science. 292(5516): 464-468.https://doi.org/10.1126/science.1059817.
- Jaakkola, P., Mole, D.R., Tian, Y.M., Wilson, M.I., Gielbert, J., et al. (2001). Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation. Science. 292(5516): 468-472. https://doi.org/10.1126/science.1059796.
- Kumar, B. and Kumar, N. (2000). Effect of altitude on some blood biochemical profile of 15 months old non-pregnant crossbred heifers. Indian Journal of Animal Research. 34(2): 108-111.
- Kumar, S., Ganguly, I., Singh, S., Sodhi, M. and Bhakat, M. (2017). Y-chromosome variation in Indian native cattle breeds and crossbred population. Indian Journal of Animal Research. 51(1): 1-7.
- Kumari, P., Bharti, V.K., Kumar, D., Mukesh, M. and Sharma, I. (2020). Haematological and biochemical profiling of Ladakhi cow: A native cattle of high altitude Leh-Ladakh, India. Indian Journal of Animal Sciences. 90(4): 599-602.
- Lendahl, U., Lee, K.L., Yang, H. and Poellinger, L. (2009). Generating specificity and diversity in the transcriptional response to hypoxia. Nature Reviews Genetics. 10(12): 821-832. https://doi.org/10.1038/nrg2665.
- Lewis, B.P., Burge, C.B. and Bartel, D.P. (2005). Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets. Cell. 120(1): 15-20. https://doi.org/10.1016/j.cell.2004.12.035.
- Mishra, A.K., Vohra, V., Raja, K.N., Singh, S. and Singh, Y. (2017). Principal component analysis of biometric traits to explain body conformation in Kajali sheep of Punjab, India. Indian Journal of Animal Sciences. 87(1): 939.
- Mishra, S.K., Mishra, A.K., Raja, K.N., Vohra, V., Singh, S., Singh, Y., Ahlawat, S. and Kataria, R.S. (2018). Polymorphism analysis at FecB locus in Kajali sheep of India. Indian Journal of Animal Research. 52 (3): 474-476.
- Mole, D.R., Blancher, C., Copley, R.R., Pollard, P.J., Gleadle, J.M., Ragoussis, J. and Ratcliffe, P.J. (2009). Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts. Journal of Biological Chemistry. 284(25): 16767-16775. https://doi.org/10.1074/jbc.M 901790200.
- Nallamshetty, S., Chan, S.Y. and Loscalzo, J. (2013). Hypoxia: A master regulator of microRNA biogenesis and activity. Free Radical Biology and Medicine. 64: 20-30. https://doi.org/10.1016/j.freeradbiomed.2013.05.022.
- Newman, J.H., Holt, T.N., Cogan, J.D., Womack, B., Phillips, J.A., Li, C., Kendall, Z., Stenmark, K.R., Thomas, M.G., Brown, R.D., Riddle, S R., West, J.D. and Hamid, R. (2015). Increased prevalence of EPAS1 variant in cattle with high-altitude pulmonary hypertension. Nature Communications. 6(1): 6863. https://doi.org/10.1038/ncomms7863.
- Price, A.L., Patterson, N.J., Plenge, R.M., Weinblatt, M.E., Shadick, N.A. and Reich, D. (2006). Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics. 38(8): 904-909. https://doi.org/10.1038/ng1847.
- Rajput, N., Shrivastav, A.B., Parmar, S.N.S., Ranjan, R., Singh, S. and Joseph, E. (2013). Characterization of 12S rRNA gene for meat identification of common wild and domestic small herbivores as an aid to wildlife forensic. Veterinary World. 6(5): 254-259.
- Schödel, J., Oikonomopoulos, S., Ragoussis, J., Pugh, C.W., Ratcliffe, P.J. and Mole, D.R. (2011). High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. Blood. 117(23): e207-e217. https://doi.org/10.1182/blood-2010-10-314427.
- Singh, S., Kankoriya, S., Jain, S.K., Jain, H. and Singh, S.P. (2014). Genetic diversity analysis of Sahiwal and Tharparker breeds of cattle (Bos indicus) by microsatellite markers. Indian Journal of Animal Research 48(5): 418-421.
- Wen, J. and Yuan, N. (1998). Analysis on the parameters of blood in healthy Tibetan Mastiffs. Journal of Qinghai Medical College. 20: 7-9.
- Wenger, R. H., Stiehl, D.P. and Camenisch, G. (2005). Integration of Oxygen Signaling at the Consensus HRE. Science Signaling. 306: re12. https://doi.org/10.1126/stke. 3062005re12.
- Wu, D.D., Ding, X.D., Wang, S., Wójcik, J.M., Zhang, Y., Tokarska, M., Li, Y., Wang, M.S., Faruque, O., Nielsen, R., Zhang, Q. and Zhang, Y.P. (2018). Pervasive introgression facilitated domestication and adaptation in the Bos species complex. Nature Ecology and Evolution. 2(7): 1139-1145. https://doi.org/10.1038/s41559-018-0562-y.
- Wu, X., Ding, X., Chu, M., Guo, X., Bao, P., Liang, C. and Yan, P. (2015). Novel SNP of EPAS1 gene associated with higher hemoglobin concentration revealed the hypoxia adaptation of yak (Bos grunniens). Journal of Integrative Agriculture. 14(4): 741-748. https://doi.org/10.1016/S2095-3119(14) 60854-6.
- Xia, X., Lemieux, M.E., Li, W., Carroll, J.S., Brown, M., Liu, X.S. and Kung, A.L. (2009). Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis. Proceedings of the National Academy of Sciences. 106(11): 4260-4265. https:// doi.org/10.1073/pnas.0810067106.
- Yu, F., White, S.B., Zhao, Q. and Lee, F.S. (2001). HIF-1 binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proceedings of the National Academy of Sciences. 98(17): 9630-9635. https://doi.org/10.1073/pnas.181341498.
- Zhang, S., Zhu, K., Zhang, Z., Wang, H. and Wang, X. (2019). Association between an indel polymorphism within the distal promoter of EGLN2 and cancer risk: An updated meta analysis. Molecular Genetics and Genomic Medicine. 7(10): e00936. https://doi.org/10.1002/mgg3.936.
Submitted Date : 17-10-2020
Accepted Date : 4-03-2021
First Online: