Loading...

Treatment of Canine Transmissible Venereal Tumour using Different Surgico-chemotherapeutic Protocols

DOI: 10.18805/IJAR.B-4310    | Article Id: B-4310 | Page : 899-903
Citation :- Treatment of Canine Transmissible Venereal Tumour using Different Surgico-chemotherapeutic Protocols.Indian Journal of Animal Research.2022.(56):899-903
Nutan Punchkande, Rukmani Dewangan, Raju Sharda, D. Jolhe, Dhaleshwari Sahu, S.K. Sidar, Devendra Yadav dewanganrukmani@gmail.com
Address : Department of Veterinary Surgery and Radiology, College of Veterinary Science and A.H., Anjora, Durg-491 001, Chhattisgarh, India.
Submitted Date : 15-09-2020
Accepted Date : 10-03-2021

Abstract

Background: Canine transmissible venereal tumour (CTVT) also known as infectious sarcoma, venereal granuloma, transmissible lymphosarcoma or sticker tumour is usually transmitted through coitus and mainly affects the external genitalia of young sexually matured dogs. Surgery, chemotherapy, radiotherapy and immunotherapy are considered as effective treatment protocols. Therefore, depending upon the availability present study was designed to investigate the efficacy of different surgico-chemotherapeutic protocols for treatment of canine transmissible venereal tumour.
Methods: The study was conducted during January 2018 to July 2018 at the Teaching Veterinary Clinical Complex (TVCC) and Department of Veterinary Surgery and Radiology, College of Veterinary Science and A.H., Anjora, Durg (C.G.) on 18 canines of various breed, irrespective of age, sex and divided into three groups consisting 6 animals in each group. Group A was treated with surgical excision of tumour only where as Group B and Group C were treated with surgical excision of tumour followed by administration of Doxorubicin (30mg/m2) BSA and Vincristine sulphate (0.025 mg/kg) intravenously alongwith DNS at 7th and 14th post-operative days respectively. Different physiological and haemato-biochemical parameters (Hb, PCV, TLC, TPC, DLC, serum glucose, TSP, SUN, SC, ALT, AST and ALP) were recorded preoperatively, postoperatively and after chemotherapy at 10th, 30th and 60th days intervals.
Result: The present investigation showed transient changes in physiological and haemato-biochemical parameters before, post surgery and post chemotherapeutic management and was within normal range. Histopathological examination revealed confluent sheet of tumour cells arranged in large round oval or polyhedral shaped distributed in tight clusters or cords. Group A showed mild to moderated reoccurrence while Group B showed minimum reoccurrence. Group C showed no reoccurrence. Thus, surgery combined with vincristine therapy is most effective for treating dogs suffering with transmissible venereal tumour.

Keywords

Canine Chemotherapy Doxorubicin Transmissible venereal tumour Treatment Vincristine

References

  1. Awan, F., Ali, M.M., Ijaz, M. and Khan, S. (2014). Comparison of different therapeutic protocol in the management of canine transmissible venereal tumour: review of 30 cases. Global Veterinaria. 12(4): 499-503.
  2. Behera, S.K., Kurade, N.P., Monsang, S.W., Das, D.P., Mishira, K.K. and Mohanta, R.K. (2012). Clinico-pathological findingsin a case of canine cutaneous metastatic transmissible venereal tumor. Veterinarski Arhiv. 82(4): 401-410.
  3. Da Silva, D.M., Reusing, M.S.O., Franciosi, A.I., Belo, C.E.P., Gonacalves, K.L., De Sousa, R.S. and Guerios, S.D. (2014). Treatment of canine transmissible venereal tumour using L-asparaginase, prednisone, and surgery in a clinical chemotherapy-resistant case. Turk. J. Anim. Sci. 38: 220-223.
  4. Das, U. and Das, A.K. (2000). Review of canine transmissible venereal sarcoma. Vet. Res. Commun. 24(5): 545-556.
  5. Gandhimathi, D., Gurupriya, G., Arivuselvan, P., Sridevi, P. and Joseph, C. (2011). Effect of doxorubicin therapy on transmissible venereal tumour in dogs. Indian Journal of Animal Reproduction. 32(2): 71-73.
  6. Hantrakul, S., Klangkaew, N., Kunakornsawat, S., Tansatit, T., Poapolathep, A., Kumagai, S. and Poapolathep, S. (2014). Clinical pharmacokinetics and effects of vincristine sulphate in dogs with transmissible venereal tumour (TVT). J. Vet. Med. Sci. 76(12): 1549-1553.
  7. Hoque, M. (2002). An update on canine transmissible venereal tumour. Intas Polivet. 3(11): 227-234.
  8. Hoque, M., Pawde, A.M. and Singh, G.R. (1995). Combination chemotherapy in canine transmissible venereal tumor. Indian Vet. J. 72: 973-975
  9. Kumar, V.V.V.A., Kumari, K.N., Kumar, K.S., Kumar, V.G. and Lakshman, M. (2018). Effect of Vincristine chemotherapy in TVT affected dogs. The Pharma Innovation Journal. 7(4): 163-166.
  10. Lori, J.C., Stein, T. J. and Thamn, D.H. (2010). Doxorubicin and cyclophosphamide for treatment of canine lymphoma:a randomized, placebo-controlled study. Vet. Comp. Oncol. 8(3): 188-195.
  11. Luna, L.G. (1968). Manual of histological staining methods. The Armed Forces institute of pathology. 3rd Edn. Mc. Graw Book Company, New York. pp: 32-46.
  12. Premsairam, C., Balagopalan, T.P., Aruljothi, N., Thiruselvame, P., Alphonse, R.M.D and Kumar, R. (2018). Management of cutaneous canine transmissible venereal tumour in a dog- a case report. International Journal of Science, Environment and Technology. 7(1): 121-125.
  13. Srivastava, A.K., Singh, B., Srivastava, A.K., Lal, H.P., Sinha, N. and Sharma, A.K. (2009). A study on chemo-surgical management of mammary tumours in dogs. Indian J. Vet. Surg. 30(1): 27-30.
  14. Swamy, M., Sharma, S. and Shahi, A. (2012). Effect of doxorubicin on canine transmissible venereal tumour. Int. J. Pharm.    Bio. Sci. 3(3): 97-104.
  15. Tella, M.A., Ajala, O.O. and Taiwo, V.O. (2004). Complete regression of transmissible venereal tumour (TVT) in Nigerian mongrel dogs with vincristine sulphate chemotherapy. African J. Biomed. Res. 7: 133-138.
  16. Upadhye, S.V. (2007). Comparative efficacy of various surgical and chemotherapeutic regimen for the treatment of canine transmissible venereal tumour, M.V.Sc. thesis submitted to Maharashtra Animal and Fishery Sciences University, Nagpur.
  17. Yadav, A., Bugalia, N. S. and Pandey, A. K. (2017). Haemato-biochemical and therapeutic evaluation of doxorubicin and vincristine in canine transmissible venereal tumour. Indian Journal of Animal Reproduction. 39 (2): 40-42. 

Global Footprints