Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

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Research Article

Indian Journal of Animal Research, volume 51 issue 6 (december 2017) : 1038-1042

Effects of Hypericum perforatum extract on the endocrine immune network factors in the immunosuppressed Wistar rat

Baocheng Hao, Xiaoyan Hu, Xuehong Wang, Yu Liu, Zhen Yang, Wenzhu Guo, Ruofeng Shang, Jianping Liang
1<p>Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Sciences, Lanzhou-730 050 ,PR China.</p>
Cite article:- Hao Baocheng, Hu Xiaoyan, Wang Xuehong, Liu Yu, Yang Zhen, Guo Wenzhu, Shang Ruofeng, Liang Jianping (2016). Effects of Hypericum perforatum extract on the endocrine immunenetwork factors in the immunosuppressed Wistar rat . Indian Journal of Animal Research. 51(6): 1038-1042. doi: 10.18805/ijar.10980.

ABSTRACT

The study aimed to investigate the effects of Hypericum perforatum extract on the endocrine immune network factors in the immunosuppressed rat. Wistar rats were used to establish an immunosuppression model. Immunosuppressed rats received Hypericum perforatum extract suspension for 7 days at doses of 600 mg/kg (containing hyperforin at 7.2mg/kg).Endocrine immune network factors including IL-1, DA, NE, and 5-HT were determined on day 8.The results indicated that Hypericum perforatum extract affects the endocrine immune network through decreasing endogenous IL-1,dopamine (DA), norepinephrine (NE), and 5- hydroxytryptamine (5-HT) levels. Hyperforin reverses immune suppression through enhancing DA levels to inhibit B cells while promoting T cell and macrophage functions to recover immune function.

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