Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

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Research Article

Indian Journal of Animal Research, volume 51 issue 1 (february 2017) : 75-79

Resveratrol regulates relevant genes to promote excretions of total sterols in long-term HF fed C57BL/6J mice

Xinhui Guo, Wei Xue, Yujiao Wang, Jiangang Zhang, Qinghong Meng, Yanlin Zhang, Heng Jian, Ning Zhang, Xiaoling Xu, Weichun Fang, Hao Wang, Erbing Hua
1<p>Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science &amp; Technology, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin, 300457, China.<br /> &nbsp;</p>
Cite article:- Guo Xinhui, Xue Wei, Wang Yujiao, Zhang Jiangang, Meng Qinghong, Zhang Yanlin, Jian Heng, Zhang Ning, Xu Xiaoling, Fang Weichun, Wang Hao, Hua Erbing (2016). Resveratrol regulates relevant genes to promote excretions of totalsterols in long-term HF fed C57BL/6J mice . Indian Journal of Animal Research. 51(1): 75-79. doi: 10.18805/ijar.11324.

ABSTRACT

Resveratrol (RSV) as a naturally occurring small molecule has been reported to benefit the cardiovascular system through a dietary supplementation. However, the relevant genetic regulation by RSV has been uncovered. This work is solely to investigate how RSV increases a fecal excretion of total sterols of HF fed C57BL/6J mice to block lipid accumulation in vivo through regulation of PPRAa, HMG-CoA-R, CYP7A1, LDL-R and ABCG5 genes. The results showed that RSV significantly improved the excretion of total sterols through up regulation of mRNA expressions of PPARa, CYP7A1, LDL-R, ABCG5 and down regulation of HMG-CoA-R. These data indicate that beneficial effects from RSV were associated with the favorably altered expression of hepatic and large intestine genes in HF fed mice.

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