Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

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Research Article

Indian Journal of Animal Research, volume 51 issue 1 (february 2017) : 75-79

Resveratrol regulates relevant genes to promote excretions of total sterols in long-term HF fed C57BL/6J mice

Xinhui Guo1, Wei Xue1, Yujiao Wang1, Jiangang Zhang1, Qinghong Meng1, Yanlin Zhang1, Heng Jiang1, Ning Zhang1, Xiaoling Xu2, Weichun Fang3, Hao Wang4, Erbing Hua1, *
1<p>Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science &amp; Technology, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin, 300457, China.<br /> &nbsp;</p>
Cite article:- Guo1 Xinhui, Xue1 Wei, Wang1 Yujiao, Zhang1 Jiangang, Meng1 Qinghong, Zhang1 Yanlin, Jiang1 Heng, Zhang1 Ning, Xu2 Xiaoling, Fang3 Weichun, Wang4 Hao, Hua1 Erbing, * (2016). Resveratrol regulates relevant genes to promote excretions of totalsterols in long-term HF fed C57BL/6J mice . Indian Journal of Animal Research. 51(1): 75-79. doi: 10.18805/ijar.11324.

ABSTRACT

Resveratrol (RSV) as a naturally occurring small molecule has been reported to benefit the cardiovascular system through a dietary supplementation. However, the relevant genetic regulation by RSV has been uncovered. This work is solely to investigate how RSV increases a fecal excretion of total sterols of HF fed C57BL/6J mice to block lipid accumulation in vivo through regulation of PPRAa, HMG-CoA-R, CYP7A1, LDL-R and ABCG5 genes. The results showed that RSV significantly improved the excretion of total sterols through up regulation of mRNA expressions of PPARa, CYP7A1, LDL-R, ABCG5 and down regulation of HMG-CoA-R. These data indicate that beneficial effects from RSV were associated with the favorably altered expression of hepatic and large intestine genes in HF fed mice.

REFERENCES


  1. Alarcón.C, D. L. L. and Villegas, I. (2007). Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications. Biochemical Society Transactions, 35: 1156-1160.

  2. Artaud-Wild, S. M., Connor, S. L., Sexton, G. and Connor, W. E. (1993). Differences in coronary mortality can be explained by differences in cholesterol and saturated fat intakes in 40 countries but not in france and finland. Circulation, 88: 2771-2779.

  3. Atten, M. J., Attar, B. M. and Milson (2001). Resveratrol-induced inactivation of human gastric adenocarcinoma cells through a protein kinase c-mediated mechanism1. Biochemical Pharmacology, 62:1423-1432.

  4. Brisdelli, F., D’Andrea, G. and Bozzi, A. (2009). Resveratrol: a natural polyphenol with multiple chemopreventive properties (review). Current Drug Metabolism,10: 530-546(17).

  5. Chan, P. T., Fong, W. P., Cheung, Y. L., Huang, Y. ,., Ho, W. K. and Chen, Z. Y. (1999). Jasmine green tea epicatechins are hypolipidemic in hamsters (mesocricetus auratus) fed a high fat diet. Journal of Nutrition, 129:1094-1101.

  6. Christoph, H., Carmela, G., Fraser, D. J., Celia, M. J., Ramiro, J. and Meyer, U. A. (2005). Species-specific mechanisms for cholesterol 7alpha-hydroxylase (cyp7a1) regulation by drugs and bile acids.. Archives of Biochemistry & Biophysics, 434:75-85.

  7. Cyril, A., Bertrand, C., Nicolas, L., Pierre Louis, T., Caroline, L. and Gérard, C., et al. (2002). Red wine phenolic compounds reduce plasma lipids and apolipoprotein b and prevent early aortic atherosclerosis in hypercholesterolemic golden syrian hamsters (mesocricetus auratus). Journal of Nutrition, 132:1207-1213.

  8. Das, S., Alagappan, V. K. T., Bagchi, D., Sharma, H. S., Maulik, N. and Das, D. K. (2005). Coordinated induction of inos–    vegf–kdr–enos after resveratrol consumption: a potential mechanism for resveratrol preconditioning of the heart. Vascular Pharmacology, 42: 281–289.

  9. Desvergne, B. and Wahli, W. (1999). Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocrine Reviews, 20: 649-688.

  10. Hung, L., Chen, J. S., Lee, R. and Su, M. (2000). Cardioprotective effect of resveratrol, a natural antioxidant derived from grapes.. Cardiovascular Research, 47: 549-555.

  11. Istvan, E. S. (2002). Structural mechanism for statin inhibition of 3-hydroxy-3-methylglutaryl coenzyme a reductase. American Heart Journal, 144: S27–S32.

  12. Jin Il, C.,Yun, A. J., Suna, K., Myung Sook, C. and Tae Youl, H. (2008). Resveratrol attenuates the expression of hmg-coa reductase mrna in hamsters. Biochemical & Biophysical Research Communications, 367: 190-194.

  13. Jiyun, A., Il jin, C., Suna, K., Daeyoung, K. and Taeyoul, H. (2008). Dietary resveratrol alters lipid metabolism-related gene expression of mice on an atherogenic diet.. Journal of Hepatology, 49: 1019–1028.

  14. Juhan-Vague, I. ,. and Alessi, M. C. (1997). Pai-1, obesity, insulin resistance and risk of cardiovascular events. Thrombosis & Haemostasis, 78:656-60.

  15. K, Lu, M H, Lee and S B, Patel. (2001). Dietary cholesterol absorption; more than just bile. Trends Endocrinol Metab, 12: 314–320.

  16. Liqing, Y., Jia, L. H., Hammer, R. E., Berge, K. E., Horton, J. D. and Cohen, J. C. (2002). Overexpression of abcg5 and abcg8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. Journal of Clinical Investigation, 110: 671-680.

  17. Miura, D., Miura, Y. and Yagasaki, K. (2003). Hypolipidemic action of dietary resveratrol, a phytoalexin in grapes and red wine, in hepatoma-bearing rats. Life Sciences, 73:1393-1400.

  18. Mowafy.El, A. M. and Alkhalaf, M. (2003). Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism. Carcinogenesis, 24: 869-873.

  19. Mukamal, K. J., Conigrave, K. M. and Mittleman, M. A. (2003). Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men.. New England Journal of Medicine, 348: 30-30.

  20. Pal, S., Ho, N. C., Dubois, P., Mamo, J., Croft, K. and Allister, E. (2003). Red wine polyphenolics increase ldl receptor expression and activity and suppress the secretion of apob 100 from human hepg2 cells. Journal of Nutrition, 133: 700-706.

  21. Remaley, A. T., Samantha, B., Walts, A. D., Lita, F., Sergey, S. and Tarmo, A. (2002). Comparative genome analysis of potential regulatory elements in the abcg5–abcg8 gene cluster. Biochemical & Biophysical Research Communications, 295: 276–282.

  22. Renaud.S, Lorgeril, M. D. (1992). Wine, alcohol, platelets, and the french paradox for coronary heart disease. Lancet, 339: 1523–1526.

  23. Revollo, J. R., Grimm, A. A. and Shin-Ichiro, I. (2004). The nad biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates sir2 activity in mammalian cells. Journal of Biological Chemistry, 279: 50754-50763.

  24. R-S,C.,P-L,W.,& Robin Y-Y,C.(2002).Peanut roots as a source of resveratrol. Journal of Agricultural & Food Chemistry, 50: 1665-1667.

  25. Rui, J., Zhang, Z., Yu, H., Yu, H. and Chen, Z. Y. (2010). Hypocholesterolemic activity of grape seed proanthocyanidin is mediated by enhancement of bile acid excretion and up-regulation of cyp7a1. Journal of Nutritional Biochemistry, 21: 1134-1139. 

  26. Sheng, L., Qian, Z., Shi, Y., Yang, L., Xi, L. and Zhao, B. (2008). Crocetin improves the insulin resistance induced by high-fat diet in rats. British Journal of Pharmacology, 154: 1016-1024.

  27. Wang, Z., Zou, J., Cao, K., Hsieh, T. C., Huang, Y. and Wu, J. M. (2005). Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels. International Journal of Molecular Medicine, 16: 533-540.

  28. Yang, C., Bei, W., Hu, Y., Le, C., Huang, L. and Wang, L. (2012). Hypocholesterolemia of rhizoma coptidis alkaloids is related to the bile acid by up-regulated cyp7a1 in hyperlipidemic rats. Phytomedicine, 19: 686-692.

  29. Zhao, Z. and Michaely, P. (2011). Role of an intramolecular contact on lipoprotein uptake by the ldl receptor. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1811: 397–408.
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