Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

  • Print ISSN 0367-6722

  • Online ISSN 0976-0555

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Indian Journal of Animal Research, volume 51 issue 1 (february 2017) : 75-79

Resveratrol regulates relevant genes to promote excretions of total sterols in long-term HF fed C57BL/6J mice

Xinhui Guo1, Wei Xue1, Yujiao Wang1, Jiangang Zhang1, Qinghong Meng1, Yanlin Zhang1, Heng Jiang1, Ning Zhang1, Xiaoling Xu2, Weichun Fang3, Hao Wang4, Erbing Hua1, *
1<p>Key Laboratory of Industrial Microbiology, Ministry of Education, College of Biotechnology, Tianjin University of Science &amp; Technology, 13th Avenue, Tianjin Economic and Technological Development Area (TEDA), Tianjin, 300457, China.<br /> &nbsp;</p>
Cite article:- Guo1 Xinhui, Xue1 Wei, Wang1 Yujiao, Zhang1 Jiangang, Meng1 Qinghong, Zhang1 Yanlin, Jiang1 Heng, Zhang1 Ning, Xu2 Xiaoling, Fang3 Weichun, Wang4 Hao, Hua1 Erbing, * (2016). Resveratrol regulates relevant genes to promote excretions of totalsterols in long-term HF fed C57BL/6J mice . Indian Journal of Animal Research. 51(1): 75-79. doi: 10.18805/ijar.11324.

Resveratrol (RSV) as a naturally occurring small molecule has been reported to benefit the cardiovascular system through a dietary supplementation. However, the relevant genetic regulation by RSV has been uncovered. This work is solely to investigate how RSV increases a fecal excretion of total sterols of HF fed C57BL/6J mice to block lipid accumulation in vivo through regulation of PPRAa, HMG-CoA-R, CYP7A1, LDL-R and ABCG5 genes. The results showed that RSV significantly improved the excretion of total sterols through up regulation of mRNA expressions of PPARa, CYP7A1, LDL-R, ABCG5 and down regulation of HMG-CoA-R. These data indicate that beneficial effects from RSV were associated with the favorably altered expression of hepatic and large intestine genes in HF fed mice.

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