Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

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Indian Journal of Animal Research, volume 55 issue 4 (april 2021) : 401-406

Immunomodulatory Efficiency of Abelmoschus esculentus in Swiss Albino Mice

K.R. Narayanan, P. Dhasarathan, M. Manujula, M. Thenmozhi
1Department of Zoology, Sri Paramakalyani College, Alwarkurichi- 627 412, Tamil Nadu, India.
Cite article:- Narayanan K.R., Dhasarathan P., Manujula M., Thenmozhi M. (2020). Immunomodulatory Efficiency of Abelmoschus esculentus in Swiss Albino Mice. Indian Journal of Animal Research. 55(4): 401-406. doi: 10.18805/ijar.B-3966.
Background: Immunomodulation through natural or synthetic substances may be considered as an alternative for prevention and cure of infections. 
Methods: A total of nineteen groups of Swiss albino mice were experimented for immunological studies with an inclusion of control and immunised control. Lymphocyte count and DTH response in the experimental groups after the administration of plant drugs. The result showed remarkable changes in all kind of treated animals when compared to control. The increment in ‘B’ and “T lymphocyte number was much pronounced in mice by the administration of A. esculentus in combination with immuno-enhansive drug. 
Result: In DTH responses directly correlated with cell mediated immunity and were found to be highest at the maximum dose (100 mg/Kg) of plant extracts A. esculuntus. From the results it was clear that the plant extract induced immunomodulating potential of the test animal. On administration of plant extract an enhanced and visible DTH responses were observed.
  1. Agarwal, S.S., Singh, V.K. (1999). Immunomodulators: A review of studies of Indian Medicinal Plants and synthetic peptides: Part I Medicinal Plants. Proceeding of the Indian National Science Academy. 65: 179-204. 
  2. Al-Rubaee, S.H., Al-Azawi, T.S., Taha.A.A. (2019). Immunological Effects of a Single Dose of PLGA Nanoparticles Encapsulated Peptide in Broilers in Comparison to Traditional Vaccines against Infectious Bursal Disease. Agricultural Science Digest. 39: 347-352.
  3. Alamgir, M., Uddin, S.J. (2010). Recent advances on the ethnomedicinal plants as Immunomodulatory agents. Ethnomedicine: A Source of Complementary Therapeutics. 6: 227-244.
  4. Descotes, J. (1999). An introduction to Immunotoxiology. Tylor Francis, London. 235- 238.
  5. Dhasarathan, P., Gomathi, R., Theriappan, P., Paulsi. S. (2010). Immunomodulatory Activity of Alcoholic Extract of Different Fruits in Mice. Journal of Applied Sciences Research INSInet Publication. 6(8): 1056-1059.
  6. Dutta, D., Bhattacharya, S.K., Bhattacharya, M.K., Deb, A.K., Deb, M., Manna, B., Moitra, A., Mukhopadhyay, A.K., Nair, G. B. (1998). Efficacy of norfloxacin and doxycycline for treatment of Vibrio cholerae O139 infection. J. Antimicrob. Chemother. 37: 575.
  7. Goldsby, A., Kindt, J., Osborne, A. (2002). Immunology. W.H.Freeman and Company, Newyork. 
  8. Gutali, K., Ray, A., Debrath, P.K., Bhattacharya, S.K. (2002). Immunomodulatory activity of Meliaaqeoua leaf extract on murine lymphocytes. J. Ind. Med. Plants. 2: 121–131.
  9. Jolly, R. D., Walkley, S.V. (1997). Lysosomal storage diseases of animals an essay in comparative pathology. Veterinary Pathology. 34: 527-548.
  10. Kalyan Sarma., Parimal Roychoudhury., Gunjan Das., Sanjoy Kumar Borthaku., Girin Kalita., Prasad, H., Chaudhary, J.K. (2019). Seroprevalence of Sarcoptes scabiei var suis infestation in swine population and its effect on haemato-biochemical and oxidative stress indices and its management with special reference to herbal ointmen. Indian Journal of Animal Research. 53: 1489-1496.
  11. Kannan, M., Ranjit Singh, A.J.A., Ajithkumar, T.T., Jegatheswari. P., Subburayalu, S. (2007). Studies on immune –bioactivities of Nyctanthesarbortristis (Okaceae). African J. of Microbio Research. 1(6): 88-91.
  12. Khatune, N.A., Mossadik, M.A., Rahman, M.M., Gray, A.I. (2005). A benzofuranone from the flowers of Nyctanthes arbor tristis and its antibacterial and cytotoxic activities. DhakaUniv J. Pharma Sc. 4(1): 102.
  13. Miller, K. L., Liebowitz, R.S., Newby, L. K. (2004). Complementary and alternative medicine in cardiovascular disease: a review of biologically based approaches. Am. Heart. J. 147: 401-411.
  14. Mitra, S., Sur, R.K. (1999). Hepatoprotection with Glycosmis pentaphylla (Retz). Indian J Exp Biol. 35(12): 1306-1309.
  15. Patwardhan, B. (2000). Ayurveda, the designer medicine a review of ethnopharmacology and bioprospecting research. Indian drugs. 37: 213 -227.
  16. Paulsi, S., Dhasarathan, P. (2011). Estimation of biochemical status and immunostimulant potential of chosen fruits. International Journal of Pharma and Bio Sciences. 2(2): 91-97.
  17. Raphael, T.J., Kuttan. G. (2003). Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic and nomilin on the immune system. Phytomedicine. 10: 483.
  18. Sharififar, F., Dehghan-Nudeh, G. H., Mirtajaldini, M. (2009). Major flavonoids with antioxidant activity from. Teucriumpolium. Food Chem. 112: 885-888. 
  19. Siheyla, K., Dugenci, N.A., Akin, C. (2003). Some medicinal plants as immunostimulant for fish. Journal of Ethonopharmacology. 88: 99-106.
  20. Sujatha, M., Dhasarathan, P., Karthika, B. (2010). Antibiotic susceptibility and immunomodulatory potential of chosen bacterial pathogens. American Journal of Immunology. 6(2): 15-19.
  21. Szalai A.J., Briles D.E., Volanakis, J.E. (1996). Role of complement in C-reactive-protein-mediated protection of mice from Streptococcus pneumoniae. Infect. Immun. 64: 4850-4853.
  22. Tiwari, U., Rastogi, B., Thakur, S., Jain, S., Jain, N.K., Saraf, D. K. (2004). Studies on the immunoomoulatory effects of cleome viscose. Ind. J. Pharm Sci. 66: 171-176.
  23. Trebeden Negre, H., Weill, B., Fournier, C., Batteux, F. (2003). B cell apoptosis accelerates the onset of murine lupus, Eur J Immunol. 33: 1603-12.
  24. Vikas Chaudhiry., Anand Kumar., Govind Mohan., Ranjeet Verma., Sushant Srivastava. (2019). The study of therapeutic efficacy of mineral mixture, herbal and ethno veterinary medicine on anoestrus buffalo heifers. Indian Journal of Animal Research. 53: 1639-1644.

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