Effect of feeding high fat diet on reproductive parameters in male mice

DOI: 10.18805/ijar.B-3528    | Article Id: B-3528 | Page : 505-509
Citation :- Effect of feeding high fat diet on reproductive parameters in male mice.Indian Journal Of Animal Research.2019.(53):505-509
Rosa J. Samuel, Omana Joy, P. Krishna Murthy, Shruthi Iyer, S.G. Ramachandra and K. Thamaraiselvi rosaj66@hotmail.com
Address : Central Animal Facility, Division of Biological Sciences, Indian Institute of Science, Bangalore-560 012, Karnataka, India.
Submitted Date : 10-11-2017
Accepted Date : 20-03-2018

Abstract

The present study attempts to chronicle the series of changes starting from the consumption of high fat diet till reproductive activity in male mice. A marginal increase in body weight was observed in male mice fed with high fat diet with 3-fold increase in total body fat and 1.4-fold increase in adipose tissue. A significant reduction in number and diameter of seminiferous tubules were observed in high fat diet fed mice compared to control mice. FACS analysis of testicular germ cells revealed very high percentage of apoptotic cells (84%) compared to control animals (2-3 %) indicative of reduced spermatogenic activity. In addition, a significant decrease in litter size (11.6%-Control to 3.66%-HFD) indicates that reproductive efficiency in high fat diet fed mice reduced to a great extent. The present study revealed high fat diet alters the fertility in male mice significantly and the first in this process appears to be apoptosis of testicular cells due to increase in ROS.

Keywords

Apoptosis High fat diet Infertility Obesity Reproductive failure Spermatogenesis.

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