Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

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Indian Journal of Animal Research, volume 50 issue 4 (august 2016) : 466-470

Changes in expression of Th1 and Th2 cytokines in bovine peripheral blood mononuclear cells during early pregnancy

Ling Yang, Yongxiang Wang, Xingshu Ma, Songping Wang, Leying Zhang*
1<p>Department of Animal Science, College of Agriculture, Hebei University of Engineering, Handan-056 021, China.</p>
Cite article:- Yang Ling, Wang Yongxiang, Ma Xingshu, Wang Songping, Zhang* Leying (2015). Changes in expression of Th1 and Th2 cytokines in bovine peripheral blood mononuclear cells during early pregnancy . Indian Journal of Animal Research. 50(4): 466-470. doi: 10.18805/ijar.5538.

Conceptus-derived signals are involved in the maternal systemic immune regulation through blood circulation and lymph circulation by peripheral blood mononuclear cells (PBMC) in cattle. There exists a Th2-biased response in maternal uterus during early pregnancy in cattle. However, it is unclear that the changes in expression of Th1 and Th2 cytokines in PBMC during early pregnancy in cows. At present study, the expression of Th1 and Th2 cytokines in PBMC were explored at day 18 non-pregnant cows, day 18 and day 30 pregnant cows. Our results showed that IFN-g was attenuated in PBMC, but TNF-a and IL-2 in PBMC were up-regulated during early pregnancy in cows. However, the member of the Th2 cytokines, including IL-4, IL-5, IL-6, IL-10 and IL-13, was augmented in day 30 pregnant PBMC. In conclusion, there existed a Th2-biased response in PBMC during early pregnancy, which was essential for successful pregnancy in cattle.

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