Protective effect of Psidium guajava leaf ethanolic extract against streptozotocin-induced diabetes and lipidosis in rats

DOI: 10.18805/ijar.B-3337    | Article Id: B-3337 | Page : 1198-1205
Citation :- Protective effect of Psidium guajava leaf ethanolic extract against streptozotocin-induced diabetes and lipidosis in rats.Indian Journal of Animal Research.2018.(52):1198-1205
R. Manikandan, A.Vijaya Anand, P. Sampathkumar and N. Manoharan mani_r_trichy@yahoo.co.in
Address : Department of Biochemistry, M.I.E.T Arts and Science College, Trichy- 620 007, Tamil Nadu, India.
Submitted Date : 14-11-2016
Accepted Date : 12-05-2017


This study was conducted to find out the anti-diabetic and hypolipidemic potential of ethanolic extract of Psidium guajava Linn leaves and its one of the important compound of caryophyllene in a streptozotocin (STZ) induced diabetic rats. The rats were divided into eight groups. Diabetes was induced by STZ at a dosage of 60 mg/kg b.w. The various dosages of extract (100, 200, 300 mg/kg b.w), caryophyllene (300 mg/kg b.w) were injected and glibenclamide (3 mg/kg b.w) is used as a standard drug. After the treatment of the extract and caryophyllene the levels of blood glucose, HbA1c, glucose-6-phosphatase, fructose-1,6-bis phosphatase, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), high density lipoprotein (HDL) were determined. Pancreatic tissue changes were noticed in all the groups. The present study showed that there was a significant reduction in blood glucose, HbA1c, glucose-6-phosphatase, fructose-1,6-bis phosphatase, TC, TG, LDL, VLDL and the enhancement was noticed in the level of  insulin, glucokinase and  HDL. Pancreas was damaged in diabetic induced rats and it altered to normal size and shape in the plant extract treated and caryophyllene treated groups. The results proved that the STZ induced diabetic rat models had revealed anti-diabetic and hypolipidemic effect treated with ethanolic leaf extract of P. guajava and caryophyllene.


Antihyperglcemic Caryophyllene Hypolipidemic Psidium guajava Streptozotocin.


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