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Current IssueEditorial BoardOnline First ArticlesArchive

Research Article

volume 52 issue 7 (july 2018) : 1031-1036,   Doi: 10.18805/ijar.B-3306

Hepatic lipidosis in transition buffaloes in relation to back fat thickness, hemato-biochemical and mineral profile

R
Randhir Singh
S
Sarnarinder Singh Randhawa
C
Charanjit Singh Randhawa
1Department of Veterinary Medicine, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-1410 04, Punjab, India
Cite article:- Singh Randhir, Randhawa Singh Sarnarinder, Randhawa Singh Charanjit (2017). Hepatic lipidosis in transition buffaloes in relation to back fat thickness, hemato-biochemical and mineral profile. Indian Journal of Animal Research. 52(7): 1031-1036. doi: 10.18805/ijar.B-3306.

ABSTRACT

The study invoved 140 buffaloes, 125 (87.41%) with ultrasonography (USG) features of normal liver and 18 (12.58%) with features of hepatic lipidosis (HL). Among the later 7 had grade I, 6 grade II and 5 grade III USG features of HL. The grouping of animals according to transition stage and evaluation of body condition score (BCS) showed that  buffaloes with moderate to severe HL lost BCS from Far off dry (FOD) to fresh stage by more than one (1.0) increment whereas, healthy buffaloes lost BCS from FOD to fresh stage by less than 0.5 increment. Significantly low levels of haemoglobin, packed cell volume and total erythrocyte count was observed in buffaloes with severe HL. Significantly low levels of total plasma protein, glucose, calcium, potassium, copper and zinc along with increased levels of plasma urea nitrogen, beta hydroxyl butyric acid, non esterified fatty acid, aspartate amino transferase, alanine amino transferase, gamma glutamyl transferase, lactate dehydrogenase and Glutamic dehydrogenase were observed in buffaloes with HL. A strong positive association exists between the severity of BCS and back fat thickness (BFT) reduction and occurrence of HL in transition buffaloes.

REFERENCES

  1. Bernabucci, U., Ronchi, B., Lacetera, N., and Nardone (2005). Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows. Journal of Dairy Science. 88: 2017-26.
  2. Bobe, G., Young, J.W., Beit, D.C., (2004) Invited review: Pathology, etiology, prevention, and treatment of fatty liver in dairy cows. Journal of Dairy Science. 87: 3105-3124.
  3. Braun, U., (2009). Ultrasonography of the liver in cattle. Veterinary Clinics of North America: Food Animal Practice. 25: 591-609.
  4. Braun, U., Nuss, K. and Soldati, G., (2005). Clinical and ultrasonographic findings in four cows with liver tumors. Veterinary Record. 157: 482-484.
  5. Cadorniga-Valino, C., Grummer, R.R., Armentano, L.E., Donkin, S.S., Bertics, S.S., (1997). Effects of fatty acids and hormones on fatty acid metabolism and gluconeogenesis in bovine hepatocytes. Journal of Dairy Science. 80: 646-656.
  6. Drackley, J.K., Overton, T.R. and Douglas, G.N., (2001). Adaptations of glucose and long chain fatty acid metabolism in liver of dairy cows during the periparturient period. Journal of Dairy Science. 84: 100-112.
  7. Ellen, S., Gerhardt, W., Henkel, E., Klauke, R., Liese, W., Lorentz, K., Sonntag, O., Stein, W. and Weidemann, G., (1992). Proposal of Standard Methods for the Determination of Enzyme Catalytic Concentrations in Serum and Plasma at 37 °C (GDH). European Journal of clinical chemistry and clinical biochemistry. 30: 493-502.
  8. Chandra, G., Aggarwal, A., Singh, A. K., Kumar, M., Kushwaha, R., Singh, A., and Singh, Y.K., (2011). Negative energy balance and reproduction: A review. Agri. Reviews, 32 (4) : 246 – 254.
  9. Jorritsma, R., Jorritsma, H., Schukken, Y.H., Bartlett, P.C., Wensing, T. and Wentink, G.H., (2001) Prevalence and indicators of post partum fatty infiltration of the liver in nine commercial dairy herds in The Netherlands. Livestock Production Science. 68: 53-60.
  10. Kalaitzakis, E., Roubies, N., Panousis, N., Pourliotis, K., Kaldrymido, E. and Karatzias, H., (2007) Clinicopathologic evaluation of hepatic lipidosis in periparturient dairy cattle. Journal of Veterinary Internal Medicine. 21:835-845.
  11. Komeilian, M.M., Sakha, M., Nadalian, M.G. and Veshkini, M., (2011). Hepatic Ultrasonography of Dairy Cattle in Postpartum Period: Finding the Sonographic Features of Fatty Liver Syndrome. Australian Journal of Basic and Applied Sciences. 5(8): 701-706.
  12. Lucy, M.C., Verkerk, G.A., Whyte, B.E., Macdonald, K.A., Burton, L., Cursons, R.T., Roche, J.R., and Holmes, C.W., (2009). Somatotropic axis components and nutrient partitioning in genetically diverse dairy cows managed under different feed allowances in a pasture system. Journal of Dairy Science. 92: 526–539.
  13. Mia, A.S. and Koger, H.D., (1978). Direct colorimetric determination of serum arginase in various domestic animals. American journal of veterinary research. 39: 1381-1382.
  14. Mohamed, T., Oikawa, S., Iwasaki, Y., Mizunuma, Y., Takehana, K., Endoh, D., Kurosawa, T., Sato, H., (2004) Metabolic profiles and bile acid extraction rate in the liver of cows with fasting-induced hepatic lipidosis. The Journal of Veterinary Medical Science. 51: 113-118.
  15. Murondot, A., Jorritsma, R., Beynen, A.C., Wensing, T., Geelen, M.J., (2004). Activities of the enzymes of hepatic gluconeogenesis in periparturient dairy cows with induced fatty liver. Journal of Dairy Research. 71: 129–134.
  16. Nanda, P.J. and Herdt, T.H., (2009). Clinical Use of Ultrasound for Subcutaneous Fat thickness Measurements in Dairy Cattle. Current veterinary therapy: food animal practice. Saunders, 5 vol. p.150-153.
  17. Ok, M., Sen, I., Guzelbektes, H., Boydak, M., ER, C., Aydogdu, U. and Yildiz, R., (2013). The importance of concentrations of sorbitol dehydrogenase and glutamate dehydrogenase and B- mode ultrasonographic examination in the diagnosis of hepatic lipidosis in dairy cows. Review Veterinary Medicine. 19(suppl-A): A117-A123.
  18. Singh, R., Randhawa, S.N.S. and Randhawa, C.S., (2015a) Oxidative stress, Hemato-biochemical and plasma mineral profile in transition buffaloes. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences. ISSN 0369-8211. DOI 10.1007/s40011-015-0684-9.
  19. Singh, R., Randhawa, S.N.S., Randhawa, C.S., (2015b). Body condition score and its correlation with ultrasonographic back fat thickness in transition crossbred cows. Veterinary World. 8(3): 290-294.
  20. Sevinc, M., Basoglu, A., Birdane, F.M. and Boydak, M., (2001). Liver function in dairy cows with fatty liver. Review of Veterinary Medicine. 15(4): 297-300.
  21. Tausky, H.H. and Shorr, E., (1953). A micro colorimetric method for determination of inorganic phosphorus. Journal of Biological Chemistry. 202: 675-85.
  22. Tharwat, M., (2012). Ultrasonography as a diagnostic and prognostic approach in cattle and buffaloes with fatty infiltration of the liver. Polish journal of veterinary sciences. Vol. 15, No. 1, 83-93. 
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Indian Journal of Animal Research
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    Research Article

    volume 52 issue 7 (july 2018) : 1031-1036,   Doi: 10.18805/ijar.B-3306

    Hepatic lipidosis in transition buffaloes in relation to back fat thickness, hemato-biochemical and mineral profile

    R
    Randhir Singh
    S
    Sarnarinder Singh Randhawa
    C
    Charanjit Singh Randhawa
    1Department of Veterinary Medicine, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-1410 04, Punjab, India
    Cite article:- Singh Randhir, Randhawa Singh Sarnarinder, Randhawa Singh Charanjit (2017). Hepatic lipidosis in transition buffaloes in relation to back fat thickness, hemato-biochemical and mineral profile. Indian Journal of Animal Research. 52(7): 1031-1036. doi: 10.18805/ijar.B-3306.

    ABSTRACT

    The study invoved 140 buffaloes, 125 (87.41%) with ultrasonography (USG) features of normal liver and 18 (12.58%) with features of hepatic lipidosis (HL). Among the later 7 had grade I, 6 grade II and 5 grade III USG features of HL. The grouping of animals according to transition stage and evaluation of body condition score (BCS) showed that  buffaloes with moderate to severe HL lost BCS from Far off dry (FOD) to fresh stage by more than one (1.0) increment whereas, healthy buffaloes lost BCS from FOD to fresh stage by less than 0.5 increment. Significantly low levels of haemoglobin, packed cell volume and total erythrocyte count was observed in buffaloes with severe HL. Significantly low levels of total plasma protein, glucose, calcium, potassium, copper and zinc along with increased levels of plasma urea nitrogen, beta hydroxyl butyric acid, non esterified fatty acid, aspartate amino transferase, alanine amino transferase, gamma glutamyl transferase, lactate dehydrogenase and Glutamic dehydrogenase were observed in buffaloes with HL. A strong positive association exists between the severity of BCS and back fat thickness (BFT) reduction and occurrence of HL in transition buffaloes.

    REFERENCES

    1. Bernabucci, U., Ronchi, B., Lacetera, N., and Nardone (2005). Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows. Journal of Dairy Science. 88: 2017-26.
    2. Bobe, G., Young, J.W., Beit, D.C., (2004) Invited review: Pathology, etiology, prevention, and treatment of fatty liver in dairy cows. Journal of Dairy Science. 87: 3105-3124.
    3. Braun, U., (2009). Ultrasonography of the liver in cattle. Veterinary Clinics of North America: Food Animal Practice. 25: 591-609.
    4. Braun, U., Nuss, K. and Soldati, G., (2005). Clinical and ultrasonographic findings in four cows with liver tumors. Veterinary Record. 157: 482-484.
    5. Cadorniga-Valino, C., Grummer, R.R., Armentano, L.E., Donkin, S.S., Bertics, S.S., (1997). Effects of fatty acids and hormones on fatty acid metabolism and gluconeogenesis in bovine hepatocytes. Journal of Dairy Science. 80: 646-656.
    6. Drackley, J.K., Overton, T.R. and Douglas, G.N., (2001). Adaptations of glucose and long chain fatty acid metabolism in liver of dairy cows during the periparturient period. Journal of Dairy Science. 84: 100-112.
    7. Ellen, S., Gerhardt, W., Henkel, E., Klauke, R., Liese, W., Lorentz, K., Sonntag, O., Stein, W. and Weidemann, G., (1992). Proposal of Standard Methods for the Determination of Enzyme Catalytic Concentrations in Serum and Plasma at 37 °C (GDH). European Journal of clinical chemistry and clinical biochemistry. 30: 493-502.
    8. Chandra, G., Aggarwal, A., Singh, A. K., Kumar, M., Kushwaha, R., Singh, A., and Singh, Y.K., (2011). Negative energy balance and reproduction: A review. Agri. Reviews, 32 (4) : 246 – 254.
    9. Jorritsma, R., Jorritsma, H., Schukken, Y.H., Bartlett, P.C., Wensing, T. and Wentink, G.H., (2001) Prevalence and indicators of post partum fatty infiltration of the liver in nine commercial dairy herds in The Netherlands. Livestock Production Science. 68: 53-60.
    10. Kalaitzakis, E., Roubies, N., Panousis, N., Pourliotis, K., Kaldrymido, E. and Karatzias, H., (2007) Clinicopathologic evaluation of hepatic lipidosis in periparturient dairy cattle. Journal of Veterinary Internal Medicine. 21:835-845.
    11. Komeilian, M.M., Sakha, M., Nadalian, M.G. and Veshkini, M., (2011). Hepatic Ultrasonography of Dairy Cattle in Postpartum Period: Finding the Sonographic Features of Fatty Liver Syndrome. Australian Journal of Basic and Applied Sciences. 5(8): 701-706.
    12. Lucy, M.C., Verkerk, G.A., Whyte, B.E., Macdonald, K.A., Burton, L., Cursons, R.T., Roche, J.R., and Holmes, C.W., (2009). Somatotropic axis components and nutrient partitioning in genetically diverse dairy cows managed under different feed allowances in a pasture system. Journal of Dairy Science. 92: 526–539.
    13. Mia, A.S. and Koger, H.D., (1978). Direct colorimetric determination of serum arginase in various domestic animals. American journal of veterinary research. 39: 1381-1382.
    14. Mohamed, T., Oikawa, S., Iwasaki, Y., Mizunuma, Y., Takehana, K., Endoh, D., Kurosawa, T., Sato, H., (2004) Metabolic profiles and bile acid extraction rate in the liver of cows with fasting-induced hepatic lipidosis. The Journal of Veterinary Medical Science. 51: 113-118.
    15. Murondot, A., Jorritsma, R., Beynen, A.C., Wensing, T., Geelen, M.J., (2004). Activities of the enzymes of hepatic gluconeogenesis in periparturient dairy cows with induced fatty liver. Journal of Dairy Research. 71: 129–134.
    16. Nanda, P.J. and Herdt, T.H., (2009). Clinical Use of Ultrasound for Subcutaneous Fat thickness Measurements in Dairy Cattle. Current veterinary therapy: food animal practice. Saunders, 5 vol. p.150-153.
    17. Ok, M., Sen, I., Guzelbektes, H., Boydak, M., ER, C., Aydogdu, U. and Yildiz, R., (2013). The importance of concentrations of sorbitol dehydrogenase and glutamate dehydrogenase and B- mode ultrasonographic examination in the diagnosis of hepatic lipidosis in dairy cows. Review Veterinary Medicine. 19(suppl-A): A117-A123.
    18. Singh, R., Randhawa, S.N.S. and Randhawa, C.S., (2015a) Oxidative stress, Hemato-biochemical and plasma mineral profile in transition buffaloes. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences. ISSN 0369-8211. DOI 10.1007/s40011-015-0684-9.
    19. Singh, R., Randhawa, S.N.S., Randhawa, C.S., (2015b). Body condition score and its correlation with ultrasonographic back fat thickness in transition crossbred cows. Veterinary World. 8(3): 290-294.
    20. Sevinc, M., Basoglu, A., Birdane, F.M. and Boydak, M., (2001). Liver function in dairy cows with fatty liver. Review of Veterinary Medicine. 15(4): 297-300.
    21. Tausky, H.H. and Shorr, E., (1953). A micro colorimetric method for determination of inorganic phosphorus. Journal of Biological Chemistry. 202: 675-85.
    22. Tharwat, M., (2012). Ultrasonography as a diagnostic and prognostic approach in cattle and buffaloes with fatty infiltration of the liver. Polish journal of veterinary sciences. Vol. 15, No. 1, 83-93. 
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