Pharmacokinetics of lincomycin following intravenous administration in febrile goats

DOI: 10.18805/ijar.v0iOF.6834    | Article Id: B-3284 | Page : 605-609
Citation :- Pharmacokinetics of lincomycin following intravenousadministration in febrile goats .Indian Journal of Animal Research.2018.(52):605-609

Meemansha Sharma and Vinod Kumar Dumka

Address :

Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana-141 004, Punjab, India.

Submitted Date : 25-07-2016
Accepted Date : 7-10-2016


Disposition of antimicrobials is known to be altered during disease conditions and fever is one of the common manifestations of bacterial infections in animals. The disposition of lincomycin (10 mg/kg, IV) during Echerichia coli endotoxin-induced fever in goats followed two compartment open model and drug was detected in plasma up to 8 h. The high AUC (39.5±6.21 mg.h/mL) indicated good antibacterial activity of lincomycin in goats. The volume of distribution and total body clearance were 3.35±0.45 L/kg and 0.28±0.03 L/h/kg, respectively. The long elimination half life 9.93± 2.83 h indicated persistence of drug for longer period in body. Lincomycin, is suggested to be repeated at 24 h interval for organisms sensitive to lincomycin having MIC up to 0.6 µg/mL for the treatment of bacterial infections manifested with fever in goats.


Fever Goats Lincomycin Pharmacokinetics.


  1. Albarellos, G. A., Montoya, L., Denamiel, G. A. A., Velo, M. C. and Landoni, M. F., (2012). Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats, Journal of Veterinary Pharmacology and Therapeutics, 35: 534-540.
  2. Albarellos, G. A., Montoya, L., Denamiel, G. A. A., Passini, S. M. and Landoni, M. F., (2013). Pharmacokinetics and skin concentrations of lincomycin after intravenous and oral administration to cats, Journal of the South African Veterinary Association, 84(1), Art. #968, 5 pages. http:// dx.doi.org/10.4102/jsava. v84i1.968.
  3. Burrows, G. E., Barto, P. B. and Weeks, B. R., (1986). Chloramphenicol, lincomycin and oxytetracycline disposition in calves with experimental pneumonic pasteurellosis, Journal of Veterinary Pharmacology and Therepeutics, 9: 213-222.
  4. Burrows, G. E., Brto, P. B., Martin, B. and Tripp M. L., (1983). Comparative pharmacokinetics of antibiotics in new born calves: chloramphenicol, lincomycin and tylosin, American Journal of Veterinary Research, 44: 1053-1057.
  5. Chaleva, E. and Nquyen, D. L., (1987). Pharmacokinetic research on Pharmachem’s lincomycin hydrochloride in pigs, Veterinarno Meditsinski Nauki, 24: 47-51.
  6. Dumka, V. K. and Singh, I., (2013). Influence of fever on the disposition of florfenicol in cross-bred calves, Philippine Journal of Veterinary Medicine, 50: 16-23.
  7. Dumka, V. K. and Srivastava, A. K., (2013). Levofloxacin disposition and urinary excretion in febrile cross bred calves, Veterinarski Arhiv, 83: 371-380.
  8. El-Sayed, M. G. A,. El-Komy, A. A. A., El-barawy, A. M. and Gehan, E. A. M., (2015). Pharmacokinetical interactions of lincomycin and amprolium in broiler chickens, Journal of Science, 5: 734-743.
  9. Giguere, S., (2006). Lincosamides, pleuromutilins, and Streptogramins. In:Antimicrobial Therapy in Veterinary Medicine, [Giguere, S. (Ed.)] 4h edn, (John Wiley, Ames, USA).
  10. Giguere, S., (2013). Lincosamides, pleuromutilins, and Streptogramins. In: Giguere, S. Prescott, J. F. and Dowling, P. M. (Eds.) Antimicrobial Therapy in Veterinary Medicine, 5th edn, (John Wiley, Ames, USA).
  11. Gibaldi, M. and Perrier, D (Eds.) (1982). Pharmacokinetics. 2nd Edn. (Marcel and Dekker Inc, New York).
  12. Gouri. S. S., Venkatachalam, D. and Dumka, V. K., (2014). Pharmacokinetics of lincomycin following single intravenous administration in buffalo calves, Tropical Animal Health and Production, 46: 1099-1102.
  13. Greene, C. E. and Boothe, D. M., (2012). Antibacterial chemotherapy. In: Infectious Diseases of the Dog and Cat, 4th edn, [Greene C. E. (Ed.)] (Elsevier Saunders, St. Louis)
  14. Huimin, L., Ji-An, L. I. and Jin-Gang, N. I. U., 2012. Application of Flow Feeding Technology to Lincomycin Fermentation, Chinese Journal of Pharmaceuticals, 43: 739-742.
  15. Jianzhong, S., Xiubo, L., Haiyang, J., and Walter, H., (2004). Bioavailability and pharmacokinetics of florfenicol in healthy sheep. Journal of Veterinary Pharmacology and Therepeutics, 27: 163-168.
  16. Kumar, S., Srivastava, A. K., Dumka, V. K., Kumar, N. and Raina, R. K., (2010). Plasma pharmacokinetics and milk levels of ceftriaxone following single intravenous administration in healthy and endometritic cows, Veterinary Research Communications, 34: 503–510.
  17. Lane, V. M., Wetzlich, S., Clifford, A., Taylor, I., and Craigmill, A. L., (2004). Intravenous and subcutaneous pharmacokinetics of florfenicol in sheep. Journal of Veterinary Pharmacology and Therepeutics, 27: 191-196.
  18. Nielsen, P. and Gyrd-Hansen, N., 1998. Bioavailibility of lincomycin after oral administration to fed and fasted pigs, Journal of Veterinary Pharmacology and Therepeutics, 21: 251-256.
  19. Papich, M. G. and Riviere, J. E. (Eds.) (2009). Chloramphenicol and Derivatives, Macrolides, Lincosamides and Miscellaneous Antimicrobials, Veterinary Pharmacology and Therapeutics, 9th edn, (Blackwell Publishing., UK), 963–965.
  20. Patel, A., (2006). Bacterial Pyoderma. In: August J.R. (Ed.) Consultations in Feline Internal Medicine. (Elsevier Saunders, St. Louis). 251–259. http://dx.doi. org/10.1016/B0-72-160423-4/50031-7, PMid:17670561
  21. Petinaki, E., Guerin-Faublee, V., Pichereau, V., Villers. C., Achard, A., Malbruny, B. and Leclercq, R., (2008). Lincomycin resistance gene lnu (D) in Streptococcus uberis, Antimicrobial Agents and Chemotherapy, 52: 626-630.
  22. Rajput, N., Dumka, V. K. and Sandhu, H. S., (2008). Influence of experimentally induced fever on the disposition of cefpirome in buffalo calves, Environmental Toxicology and Pharmacology, 26: 305-308.
  23. Toutain, P. L. and Lees, P., (2004). Integration and modelling of pharmacokinetic and pharmacodynamic data to optimize dosage regimens in veterinary medicine, Journal of Veterinary Pharmacology and Therapeutics, 27: 467–477.
  24. Turnidge, J. D., (1998). The Pharmacodynamics of beta- lactams, Clinical Infectious Diseases, 27: 10-22. 
  25. Van Miert, A. S. J. P. A. M., (1987). Fever, anorexia and forestomach hypomotility in ruminants, Veterinary Research Communications, 11: 407-422.
  26. Weber, D. J., Barbiers., A. R. and Lallinger, A. J., (1981). Pharmacokinetics of lincomycin in bovine following intravenous and intramammary doses of lincocin, Upjohn Technical Report.

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