Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

  • Print ISSN 0367-6722

  • Online ISSN 0976-0555

  • NAAS Rating 6.50

  • SJR 0.263

  • Impact Factor 0.4 (2024)

Frequency :
Monthly (January, February, March, April, May, June, July, August, September, October, November and December)
Indexing Services :
Science Citation Index Expanded, BIOSIS Preview, ISI Citation Index, Biological Abstracts, Scopus, AGRICOLA, Google Scholar, CrossRef, CAB Abstracting Journals, Chemical Abstracts, Indian Science Abstracts, EBSCO Indexing Services, Index Copernicus
Indian Journal of Animal Research, volume 52 issue 5 (may 2018) : 674-677

Thyroid hormones and lipid profile in Labrador Retriever male dogs

K. Megha, M. Narayana Swamy, L. Ranganath, Suguna Rao, N. B. Shridhar, M. P. Veena, P. T. Ramesh
1<p>Department of Veterinary Physiology,&nbsp;Veterinary College, KVAFSU, Hebbal, Bangalore-560 024, Karnataka, India.</p>
Cite article:- Megha K., Swamy Narayana M., Ranganath L., Rao Suguna, Shridhar B. N., Veena P. M., Ramesh T. P. (2017). Thyroid hormones and lipid profile in Labrador Retriever male dogs . Indian Journal of Animal Research. 52(5): 674-677. doi: 10.18805/ijar.v0iOF.8494.

A study was conducted to assess the thyroid hormones and lipid profile in Labrador Retriever male dogs presented to the Veterinary College Hospital, Bengaluru for routine health check up and vaccination. Based on their age, they were randomly divided into Group I, Group II and Group III that consisted of one to three years age (young age), more than three years to six years age (middle age) and more than six to nine years age (old age), respectively. In all the dogs the body weight was recorded. The profile of thyroid hormones such as thyroid stimulating hormone (TSH), triiodothyronine (T3) and  Thyroxine (T4) were estimated by using ELISA kits. The lipid profile parameters such as triglycerides, cholesterol and HDL cholesterol were estimated by using biochemical reagent kits. The values of LDL and VLDL cholesterol were calculated by using Friedewald formula. Further, the blood glucose level was estimated using the Glucochek® glucometer and serum total protein level by using reagent kit. Results revealed that the increased body weight was observed as age advanced. The T3 levels did not vary significantly among different age groups. Whereas, in the advanced age groups there was reduction in T4 levels and increase in TSH levels which was suggestive of hypothyroidism. Triglycerides, cholesterol, LDL and VLDL levels were significantly higher in older dogs followed by middle age group compared to young age group. However, the alterations in blood glucose and serum total protein levels were non significant between different age groups. It was concluded that the Labrador Retriever male dogs could be more prone to hypothyroidism and hyperlipidemia and therefore master health check-up could be taken up at least once in a year as a precautionary measure to avoid complications of hypothyroidism and hyperlipidemia.


  1. Abraham, R., Murugan. V. S., Pukazhvanthen P. and Sen S. K. (2009). Thyroid disorders in women of Puducherry. Indian J. Clin. Biochem., 24: 52-59.

  2. ariyibi, a. a., oyeyemi m. o. and ajadi r. a. (2002). a comparative study of some haematology and biochemical parameters of clinically healthy Alsatian and local dogs. Afr. J. Biomed. Res., 5: 145-147.

  3. Barrie, J., T. Watson. D. G.,   Stear M. J. and Nash A. S. (1993). Plasma cholesterol and lipoprotein concentrations in the dog: The effects of age, breed, gender and endocrine disease. J. Small. Anim. Pract., 34: 507-512.

  4. Comazzi, S., Pieralisi C. and Bertazzolo W.(2004). Haematological and biochemical abnormalities in canine blood: frequency and associations in 1022 samples. J. Small. Anim. Pract., 45: 343-350.

  5. Gesing, A., Lewinski A. and Lewinska M. K. (2012). The thyroid gland and the process of aging; what is new? Thyroid Res., 5: 1-5.

  6. Gulzar, S., Khurana. R, Agnihotri. D., Aggarwal A. and Narang G.   (2014). Prevalence of hypothyroidism in dogs in         Haryana. Indian  J. Vet. Res., 23: 1-9.

  7. Guyton, A. C. and Hall J. E. (2006). Thyroid Metabolic Hormones. In: Text book of Medical Physiology. Edn. 11th, Elsevier’s Health Sciences Rights Department, Philadelphia,  USA, pp. 931-935.

  8. Jeusette, I., Grauwels M., Cuvelier. C.,  Tonglet. C.,  Istasse L. and Diez M. (2004). Hypercholesterolemia in a family of rough Collie dogs. J. Small. Anim. Practice., 45 : 319-324.    

  9. Kaneko, J. J., Harvey J. W. and Bruss M. L. (1997). Thyroid function. In: Clinical Biochemistry of Domestic Animals. Edn.  5th Academic Press, USA., pp. 45-80.

  10. Kumar, S. K. M. (2009). Study on hypothyroidism in dogs with dermatological disorders. MVSc Thesis, Karnataka Veterinary, Animal and Fisheries Sciences University, Bidar, Karnataka, India.

  11. Liberopoulos, E. N. and Elisaf M. S. (2002). Dyslipidemia in patients with thyroid disorders. Hormone., 1: 218-223.

  12. Mansoor, R., Rizvi S. S. R.,  Kausar W., Aslam F. and. Huda S. T. (2011). Comparison of TSH, T4 and T3 levels in primary hypothyroidism in relation to gender and age in a Tertiary care hospital. Ann. Pak. Inst. Med. Sci., 7: 186-190.

  13. Patkar, R. P., Dalvi S. H. and Kumarasamy J. (2014). Serum thyroid hormone levels during growth period in Labrador dog. Indian J. Field Vet., 9: 1-3.

  14. Pattanayak, S., Batabyal S. and Patra A. (2014). A  study  on  effect  of  age,  breed  and  sex  on blood  sugar  level  of diseased  dogs. Explor. Anim. Med. Res., 4: 33-43.

  15. Prakash, A. and.  Lal. A. K (2006). Serum lipids in hypothyroidism: our experience. Indian J. Clin. Biochem., 21: 153-155.

  16. Regmi, A., Shah B., Rai B. R.  and Pandeya A. (2010). Serum lipid profile in patients with thyroid disorders in central Nepal.         Nepal Med. Coll. J., 12: 253-256.

  17. Reimers, T. J., Lawler. D. F., Sutaria. P. M., Correa M. T. and Erb H. N.  (1990). Effects of age, sex and body size on serum concentrations of thyroid and adrenocortical hormones in dogs. Am. J. Vet. Res., 51: 454-457. 

  18. Senturk. S., Yilmaz Z. and Kennerman E. (2002). The comparison of total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and total cholesterol: high density lipoprotein cholesterol ratios in breeds of Labrador Retriever Dogs, German Shepherd Dogs, Pointer Dogs. Uludag Univ. J. Fac. Vet. Med., 21: 9-12.

  19. Tietz, N. W. (1986). Textbook of Clinical Chemistry.  W. B. Saunders, Philadelphia, pp. 579. 

  20. usui, s., mizoguchi y.,  yasuda. h., arai n. and Koketsu U. (2014). Dog age and breeds associated with high plasma cholesterol  and triglyceride concentrations. J. Vet. Med. Sci., 76: 269-272.

  21. Verma, A., Jayaraman M., Kumar H. K. V. S. and Modi K. D. (2008). Hypothyroidism and obesity. Saudi Med. J., 29: 1135-1138.

  22. Zoran, D. L. (2010). Obesity in dogs and cats : A metabolic and endocrine disorder. Vet. Clin. Small Anim., 40: 221-239.  

     

Editorial Board

View all (0)