Indian Journal of Animal Research

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Research Article

Indian Journal of Animal Research, volume 52 issue 4 (april 2018) : 533-537

Association study of Single Nucleotide Polymorphisms (SNP) in Toll-like Receptor 9 gene with bovine tuberculosis 

Ashish Bhaladhare, Deepak Sharma, Anuj Chauhan, Amit Kumar, Arvind Sonwane, Ran Vir Singh, Pushpendra Kumar, Subodh Kumar, Bharat Bhushan
1<p>Division of Animal Genetics,&nbsp;Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India.</p>
Cite article:- Bhaladhare Ashish, Sharma Deepak, Chauhan Anuj, Kumar Amit, Sonwane Arvind, Singh Vir Ran, Kumar Pushpendra, Kumar Subodh, Bhushan Bharat (2017). Association study of Single Nucleotide Polymorphisms (SNP) in Toll-likeReceptor 9 gene with bovine tuberculosis . Indian Journal of Animal Research. 52(4): 533-537. doi: 10.18805/ijar.v0iOF.7257.

ABSTRACT

Toll-like Receptor 9 (TLR9) play an important role in recognition of components of intracellular pathogens like Mycobacterium bovis and subsequent activation of both innate and adaptive immune response and is potential strong candidates for investigating genetic basis of disease resistance. Present investigation was aimed at exploring the association of four SNPs in TLR9 gene with susceptibility/resistance against bovine tuberculosis infection in cattle. Three of SNPs under investigation (rs210982793, rs207807011, rs209190268) revealed polymorphism whereas monomorphism was observed in SNP rs55617140. SNP loci rs210982793 and rs207807011 were significantly (P < 0.01) associated with susceptibility to bovine tuberculosis in the case control population. Both these SNPs loci were non-synonymous, thus suggestive of their functional role in the immune response against bovine tuberculosis.  

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