Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

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Indian Journal of Animal Research, volume 52 issue 9 (september 2018) : 1324-1330

Sub-acute oxidant and histopathological effects of imidacloprid on kidney of adult female Wistar rats

Archana Lohiya, Vinod Kumar, J.S. Punia
1Department of Veterinary Pharmacology and Toxicology, Lala Lajpat Rai University of Veterinary and Animal sciences, Hisar-125 001, Haryana, India.
Cite article:- Lohiya Archana, Kumar Vinod, Punia J.S. (2018). Sub-acute oxidant and histopathological effects of imidacloprid on kidney of adult female Wistar rats. Indian Journal of Animal Research. 52(9): 1324-1330. doi: 10.18805/ijar.B-3243.
Imidacloprid is a neonicotinoid insecticide and has been extensively used as a crop pest and pet flea control programme. In the present study, the effects of imidacloprid on kidney tissue were analyzed in adult female Wistar rats at two dose levels (19 and 38 mg/kg/day) administered orally for 10, 20 and 30 days. Effects were compared with respective control animals administered daily with 2% gum acacia. Different parameters undertaken were kidney weight, levels of cytoplasmic and membrane proteins, oxidative stress parameters viz. activities of SOD, GPx and levels of GSH and MDA and histopathological changes. Imidacloprid at 38 mg/kg dose administered orally for 20 and 30 days significantly increased organ weight and levels of MDA. The activities of enzymes SOD and GPx and levels of GSH were decreased significantly at 38 mg/kg dose administered daily for 30 days. There was significant decrease observed in levels of cytoplasmic and membrane proteins at 38 mg/kg dose administered orally for 20 and 30 days. Histopathological changes in kidney at 38 mg/kg dose in 20 and 30 days group. Therefore, it is concluded that imidacloprid has generated oxidative stress in kidney at 38 mg/kg dose administered orally for 20 and 30 days in adult female Wistar rats. 
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