Loading...

Histopathological alterations of selenium toxicity induced in broiler (Birds)
 

DOI: 10.18805/ijar.v0iOF.7259    | Article Id: B-3242 | Page : 599-604
Citation :- Histopathological alterations of selenium toxicity induced in broiler (Birds) .Indian Journal of Animal Research.2018.(52):599-604

Deepak Kumar, Avnish Kumar Gautam and Manoj Kumar Sinha

dravnishgautam@gmail.com
Address :

Department of Veterinary Pathology, Bihar Veterinary College, Patna- 800 014, Bihar,  India.

Submitted Date : 16-05-2016
Accepted Date : 27-09-2016

Abstract

A study was conducted to determine the pathological toxic effect of selenium (Sodium selenite). A total number 120 one day old White Leghorn (WLH) healthy broiler birds were randomly divided into A, B and C groups. Each group contain 40 birds daily administration of sodium selenite @ 30ppm and @ 15 ppm in group A and B, respectively and group C was given plain drinking water daily for 42 days and kept as control. Macroscopically and microscopically revealed varying degrees of congestion and haemorrhages in lungs, liver, kidneys, heart and intestine in selenium treated birds. The bursa of Fabricius showed depletion of lymphoid cells between the interfollicular spaces. A significant (P<0.05) decrease in the haemoglobin and packed cell volume was noticed in both the selenium fed groups but the total erythrocyte count remain unchanged. Biochemical parameter revealed slight decline in their activity of serum ALT and AST and increased level of BUN and creatinine in group A and B as compared to group C, suggesting some degree of renal dysfunctioning.
 

Keywords

Broiler birds Selenium Histopathology.

References

  1. Ahmed, K. E., Adam, S.E.L., idris, O. F. and Tageldin, M. H. (1988). Haematological and serum changes in goats experiementally intoxicated with sodium selenite. Revue. Elev. Med. Vet. Pays trop. 41 : 319-325 (Vet. Bull. 59:5441).
  2. Bancroft, J.D and Stevns, A. (2008).Theory and Practice of Histological Techniques. 6th edn. Churchill Livingstone, Edinburgh.
  3. Brown, J.M.M. and de Wet, P.J. (1962). A preliminary report on the occurrence of selenosis in South Africa and its possible role in the aetiology of tribulosis, enzootic icterus and some other disease conditions encountered in the Karoo areas. Onderstepoort J. vet. Res. 29 : 111-135.
  4. Das, P.M., Sadana, J.R., Gupta, R.K.P and Gupta,R.P. (1989a). Experimental selenium toxicity in Guinea pigs : Haematological studies, Ann.Nutr.Metab, 33:347-353.
  5. Das, P.M., Sadana, J.R., Gupta, R.K.P. and Kumar, K. (1989b). Experimental Selenium toxicity in Guineapigs : Biochemical Studies. Ann. Nutr. Metab. 33 : 57-63.
  6. El-Begearmi, M.M. and Combs, G.F. Jr. (1982). Dietary effects on selenite toxicity in the chick. Poult. Sci. 61 : 770-776.
  7. Folin, O. and Wu, H. (1919). Blood analysis; Determination of creatinine. In: Hawk’s Physiological chemistry. [Bernard, L.O. (Ed.)] 14th edn. McGraw Hill Book Co.; New York, pp-1040-1043. 
  8. Ganguli,S (2013). Effect of induced toxic pathological effect of pharmaceutical agent and heavy metals on broiler birds. Int.Res.J.Pharma 4: 5.
  9. Gessler, M. (1965). Factors affecting changes in enzyme content in the blood fowls. Vet.Med. 12A : 471-478.
  10. Jacevic, V., Jokic, G., Simic, V.D., Bokonjic, D., Vucinic, S and Vuksa, M. (2011). Acute toxicity of sodium selenite in rodents; Pathomorphological study. Military Med Sci Lett 80: 90-96.
  11. Jain,N.C (1993). Essentials of Vety Haematology. Lea and Febiger.Philadelphia, pp.19-71.
  12. Kind, P.R.N and King, K.J. (1954). Estimation of serum alkaline phosphatise by determination of hydrolysed phenol with amino antipyrne. Journal of Clinical Pathology, 7:332.
  13. Marsh,J.A.,Dietert,R.R and Combs,J.F (1981).Influence of dietary selenium and Vitamin E on the humoral immune response of the chick. Proc.Exp.Bio Med, 166:228-236.
  14. Mirjana, T., Jovanovic, M., Jokic, J., Hristov, S., Vensa, D. (2004). Alterations in liver and kidneys of chickens fed with high levels of sodium selenite or selenized yeast. Acta Veterinaria (Beograd) 54: 191-200.
  15. Mohmadsadik, M-A and Lalita. Koul. (2000). Induced selenium toxicity in broiler chicks. Jay research foundation. 2 : 6- 12.
  16. Oldfield, J.E. : (1987). The two faces of selenium. J. Nutr. 117 : 2002-2008.
  17. Prasad, B., Nauriyal, D.C. and Sandha, H.S. (1982) chromic hepatic jaundice in buffalo cow. Indian J. Vet. Med. 2 : 81-83.
  18. Reitman, S and Frankel. S. (1957). A colorimeter method for determination of serum glutamic oxaloacetic acid and glutamic pyruvic transminase, American Journal of Clinic Pathology, 28:55-63.
  19. Salyi, G., Banhidi, G., Szabo, E., Gonye, S. and Ratz, F. (1993). Acute selenium poisoning in broilers. Magy. Allatorv Lap. 48 : 22-26.
  20. Sandholom, M. (1993). Acute and chronic selenium toxicity . Norwegian J. Agri. Sci. 11:37-50.
  21. Schalm, O.W.,Jain,N.C and Carrole,E.J. (1986). Veterinary Haematology, 4th edition. Lea and Febiger. Philadelphia.
  22. Skeggs, (1957). Blood analysis: Diacetyl monoxime method for estimating urea nitrogen In:Hawk’s Physiological Chemistry Bernard, L.O. (Ed) 14th edn. Me Graw hil book Co. New York. PP: 1038-1039.
  23. Sukra, Y.; Sastrohadinote, S. and Budiarso , I.I. (1976). Effect of selenium and mercury on gross morphology and histopathology of chick embryos. Poult. Sci. 55 : 2424-2433.
  24. Wotten, I.D. P. (1974). Microanalysis in medical biochemistry. 5th edn. Churchill Livingston, Edinburg. 
     

Global Footprints