Indian Journal Of Animal Research

Polymorphism analysis at FecB locus in Kajali sheep of India

DOI: 10.18805/ijar.v0i0f.3796    | Article Id: B-3234 | Page : 474-476
Citation :- Polymorphism analysis at FecB locus in Kajali sheep of India .Indian Journal Of Animal Research.2018.(52):474-476

S.K. Mishra, A.K. Mishra, K.N. Raja, V. Vohra, S. Singh, Y. Singh,  S. Ahlawat and R.S. Kataria

anilmishra65@gmail.com
Address :

ICAR- National Bureau of Animal Genetic Resources, Karnal-132 001, Haryana, India.

Submitted Date : 29-04-2016
Accepted Date : 29-06-2016
First Online:

Abstract

The present study reports the polymorphism study of bone morphogenetic protein receptor (BMPR- 1B) FecB mutation in Kajali sheep of India. Blood samples were collected from native tract i.e. Sangrur, Barnala, Ludhiana and Moga districts of Punjab, India. Screening of 40 DNA samples revealed absence of FecB carriers in this population. The results thus indicate that either other genetic mutations or simple management practices (mostly the feeding), could be responsible for high fecundity in Kajali population, thus these animal deserve further investigation.

Keywords

FecB gene Kajali sheep Polymorphism.

References

  1. Amr, A.; EL-Hanafy and El-Saadani, M. A . (2009). Fingerprinting of FecB gene in five Egyptian sheep breeds. Biotechnol. Anim. Husb. 25: 205-212.
  2. Anonymous. (2015). Annual Report, ICAR- National Bureau of Animal Genetic Resources, Karnal, Haryana 132001 India, pp 18.
  3. Davis, G.H. (2004). Fecundity genes in sheep. Anim. Reprod. Sci. 82–83:247-253.
  4. Davis, G. H.; Balakrishanan, L.; Ross, I. K,; Wilson, T.; Galloway, S. M.; Lumsden, B. M.; Hanrahan, J. P.; Mullen, M.; Mao, X. J.; Wang, G. L.; Zhao, Z. S.; Zeng, Y. Q.; Robinson, J. J.; Mavrogenis, A. P.; Papacgristoforou, C.; Peter, C.; Baumung, R.; Cardyn, P.; Boujenane, I.; Cockett, N. E.; Eythorsdottir, E.; Eythorsdottir, E.; Arranj, J. J and Notter, D. R. (2006). Investigation of the Booroola (FecB) and Inverdale (FecXI ) mutations in 21 prolific breeds and strains of sheep sampled in 13 countries. Anim. Reprod. Sci. 92: 87-96.
  5. Davis, G. H.; Galloway, S. M.; Ross, I. K.; Gregan, S. M.; Ward, J.; Nimbkar, B. V.; Ghalsasi, P. M.; Nimbkar, C.; Gray, G. D.; Subandriyo, Inounu. I.; Tiesnamurti, B.; Martyniuk, E.; Eythorsdottir, E.; Mulsant, P.; Lecerf, F.; Hanrahan, J. P.; Bradford, G. E and Wilson, T. (2002). DNA tests in prolific sheep from eight countries provide new evidence on origin of the Booroola (FecB) mutation. Biol. Reprod. 66: 1869–1874.
  6. Hua, G. and Yang, L. (2009). A review of research progress of FecB gene in Chinese breeds of sheep. Anim. Reprod. Sci. 116: 1-9.
  7. Kumar, S.; Kolte, A. P.; Mishra, A. K and Singh, V. K. (2006). Evidence that twining rate in Malpura sheep is not linked with Booroola fecundity (FecB) gene. Ind. J. of Anim. Sci. 76: 764-767.
  8. Kumar, S.; Mishra, A. K.; Kolte, A. P.; Dash, S. K and Karim, S. A. (2008). Screening for Booroola and Galway (FecXG) mutations in Indian sheep. Small Rumin. Res. 80: 57-61.
  9. Montgomery, G. W.; Crawford, A. M.; Penty, J. M.; Dodds, K. G.; Ede, A. J.; Henry, H. M.; Pierson, C. A.; Lord, E. A.; Galloway, S. M.; Schmack, A. E.; Sise, J. A.; Swarbrick, P. A.; Hanrahan, V.; Buchanan, F. C and Hill, D. F. (2003). The ovine Booroola fecundity gene (FecB) is linked to markers from a region of human chromosome 4q. Nature Genet. 4: 410-414. 
  10. Nimbkar, C.; Ghalsasi, P. M.; Maddox, J. F.; Pardeshi, V. C; Sainani, M. N.; Gupta, V and Walkden-Brown, S. W. (2003). Expression of FecB gene in Garole and Crossbred ewes in Maharastra, India. In the Proceedings of the fifteenth conference of AAABG, Melbourne, Australia. p111-114. 
  11. Sambrook, J and Russell, D. W. (2001). Molecular Cloning: A laboratory manual. 3rd edition.Volume 1. Cold Spring Harbor Laboratory press, New York, USA.
  12. Sonika, Ahlawat.; Sharma, R.; Maitra, A.; Raja, K. N.; Verma, N. K and Tantia, M. S. (2015). Prolificacy in Indian goat breeds is independent of FecB mutation. Ind. J. of Anim. Sci. 85: 617–620.
  13. Sudhakar, A.; Rajendran, R and Rahumathulla, P. S. (2013). Detection of Booroola (FecB) mutation in Indian sheep-    Nilagiri. Small Rumin. Res. 113: 55–57.
  14. Sudhakar, A.; Sithimarjitha, I.; Pramod, S and Rajendran, R. (2014). Polymorphism of FecB gene in Mecheri sheep of India. J. Cell Tissue Res. 14: 4055–4058.
  15. Wilson, T.; Wu, X. Y.; Juengel, J. L.; Ross, I. K.; Lumsden, J. M.; Lord, E. A.; Dodds, K. G.; Wallimg, G. A.; McEvan, J. C. O.; Connel, A. R.; McNatty, K. P and Montgomery, G. W. (2001). Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK-6) that is expressed in both oocytes and granulosa cells. Biol. Reprod. 64: 1225-1235.
  16. Yatoo, S. A.; Taggar, R. K.; Chakraborty, D.; Kumar, N.; Kumar, D and Vohra, V. (2015). Status of FecB gene mutation in Dorper Sheep from Jammu. J. Anim. Res. 5: 253-55.
     

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