Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

  • Print ISSN 0367-6722

  • Online ISSN 0976-0555

  • NAAS Rating 6.50

  • SJR 0.263

  • Impact Factor 0.4 (2024)

Frequency :
Monthly (January, February, March, April, May, June, July, August, September, October, November and December)
Indexing Services :
Science Citation Index Expanded, BIOSIS Preview, ISI Citation Index, Biological Abstracts, Scopus, AGRICOLA, Google Scholar, CrossRef, CAB Abstracting Journals, Chemical Abstracts, Indian Science Abstracts, EBSCO Indexing Services, Index Copernicus
Submit

Research Article

Indian Journal of Animal Research, volume 51 issue 4 (august 2017) : 762-763

Isoflurane sparing effect of diazepam and midazolam to xylazine-ketamine induction and isoflurane maintenance in goats

D. Vishnugurubaran, S. Kathirvel, S. Senthilkumar, K. Balasundaram, S. Dharmaceelan
1<p>Department of Veterinary Surgery and Radiology,&nbsp;Veterinary College and Research Institute, Namakkal-637 002, India.</p>
Cite article:- Vishnugurubaran D., Kathirvel S., Senthilkumar S., Balasundaram K., Dharmaceelan S. (2016). Isoflurane sparing effect of diazepam and midazolam to xylazine-ketamine induction and isoflurane maintenance in goats . Indian Journal of Animal Research. 51(4): 762-763. doi: 10.18805/ijar.v0iOF.4567.

ABSTRACT

The clinical study was undertaken to assess the isoflurane sparing effect of diazepam and midazolam during isoflurane anaesthesia in goats. The study was conducted in 12 clinical cases of goats randomly divided into two equal groups. In all the animals, xylazine hydrochloride was administered at the dose rate of 0.05 mg per kg body weight intramuscularly. In group I and II, diazepam and midazolam were administered at the dose rate of 0.5 mg per kg body weight i.v. respectively, prior to induction of anaesthesia. Anaesthesia was induced with ketamine hydrochloride at the dose rate of 5 mg per kg body weight i.v. and was maintained with isoflurane employing rebreathing circuit. The end-tidal isoflurane concentration required to maintain surgical plane of anaesthesia was significantly lower in group II (0.82 ± 0.03 per cent) indicating that inclusion of midazolam in the anaesthetic protocol had significant (28 per cent) isoflurane sparing effect.

REFERENCES


  1. Dzikiti, T.B., Stegmann,G.F., Dzikiti,L.N. and Hellebrekers,L.J. (2011b). Effects of midazolam on isoflurane minimum alveolar concentration in goats. Small Ruminant Res., 97: 104-109.

  2. Gangle, M., Gruike,S., Detilleux,J., Caudron,I. and Serteyn,D. (2001). Comparision of thiopentone / guaifenesin, ketamine / guaifenesin and ketamine / midazolam for the induction of horses to be anaesthetized with isoflurane. Vet. Rec., 149: 147-151.

  3. Riebold, T.W. (1996). Ruminants. In: Thurmon, J.C., Tranquilli,W.J. and Benson,G.J. (Eds.), Lumb and Jones’ Veterinary Anaesthesia. 3rd edn., Williams and Wilkins, Baltimore, USA. pp. 610-626.

  4. Snedecor, G.M. and Cochran,W.C. (1994). Statistical Methods. 9th edn., Oxford and IBM Publishing Company, Mumbai, India.

  5. Stegmann, G.F. and Bester,L. (2012). Preliminary investigation into the ventilator effects of midazolam in isoflurane-    anaesthetised goats. J. S. Afr. Vet. Assoc., 83: 1-3.

  6. Taylor, P.M. (1991). Anaesthesia in sheep and goats. In pract., 13: 31-36.

  7. Thurmon, J.C., Tranquilli,W.J. and Benson,G.J. (1996). Lumb and Jones’ Veterinary Anaesthesia. 3rd edn., Williams and Wilkins, Baltimore, USA.

  8. Tranquilli, W.J., Thurmon, J.C. and Grimm, K.A. (2007). Lumb and Jones’ Veterinary Anesthesia and Analgesia. 4th edn., Blackwell Publishers, Iowa, USA.

     
Reviewed By

Download Article
In this Article
    Contact us
    Follow us

    Editorial Board

    View all (0)