Indian Journal of Animal Research

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Research Article

Indian Journal of Animal Research, volume 51 issue 4 (august 2017) : 762-763

Isoflurane sparing effect of diazepam and midazolam to xylazine-ketamine induction and isoflurane maintenance in goats

D. Vishnugurubaran, S. Kathirvel, S. Senthilkumar, K. Balasundaram, S. Dharmaceelan
1<p>Department of Veterinary Surgery and Radiology,&nbsp;Veterinary College and Research Institute, Namakkal-637 002, India.</p>
Cite article:- Vishnugurubaran D., Kathirvel S., Senthilkumar S., Balasundaram K., Dharmaceelan S. (2016). Isoflurane sparing effect of diazepam and midazolam to xylazine-ketamine induction and isoflurane maintenance in goats . Indian Journal of Animal Research. 51(4): 762-763. doi: 10.18805/ijar.v0iOF.4567.

ABSTRACT

The clinical study was undertaken to assess the isoflurane sparing effect of diazepam and midazolam during isoflurane anaesthesia in goats. The study was conducted in 12 clinical cases of goats randomly divided into two equal groups. In all the animals, xylazine hydrochloride was administered at the dose rate of 0.05 mg per kg body weight intramuscularly. In group I and II, diazepam and midazolam were administered at the dose rate of 0.5 mg per kg body weight i.v. respectively, prior to induction of anaesthesia. Anaesthesia was induced with ketamine hydrochloride at the dose rate of 5 mg per kg body weight i.v. and was maintained with isoflurane employing rebreathing circuit. The end-tidal isoflurane concentration required to maintain surgical plane of anaesthesia was significantly lower in group II (0.82 ± 0.03 per cent) indicating that inclusion of midazolam in the anaesthetic protocol had significant (28 per cent) isoflurane sparing effect.

REFERENCES


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