Protective role of garlic against malathion induced oxidative stress in male albino rats

DOI: 10.18805/ijar.10712    | Article Id: B-291 | Page : 324-329
Citation :- Protective role of garlic against malathion induced oxidativestress in male albino rats .Indian Journal Of Animal Research.2016.(50):324-329

Gamila A.M. Kotb1,2,  Farag A.A. Gh 3,  Kholoud S Ramadan*4  and  Hoda E.A. Farid4,5

ramadankholoud@yahoo.com
Address :

Department of Biochemistry, Faculty of Science-Al Faisaliah Campus, King Abdulaziz University, Jeddah, Saudi Arabia.

Abstract

The garlic has been widely used as medicinal plant for its therapeutic properties This  study was aimed to investigate the antioxidant role of garlic (G) against oxidative stress induced by  malathion (M) in male albino rats. After experimental period (28 days), the study investigated some biochemical parameters and oxidative stress markers in plasma rats.  The results revealed that, malathion induced significant increase in plasma Tri-iodothyronine (T3), Thyroxin (T4),  glucose values and malondialdehyde (MDA) as oxidative stress marker was noticed. However, significant decrease was recorded in cholesterol, total protein (T. Protein) contents and  in defense system biomarker total SH- protein. Acetylcholinesterase (AChE) activity  was inhibited by malathion treatment and cause alteration in non-specific esterase and protein pattern. Finally, these results concluded that garlic has significant protection against malathion intoxication demonstrated inhibition in acetyl cholinesterase (AChE) activity and reduced in cholesterol, T. protein  and total SH- protein. Further studies are necessary to investigate the significant effect of garlic on thyroid gland, brain and neurotransmitters.

Keywords

AChE Cholesterol Esterases Garlic Glucose Malathion MDA Protein Electrophoresis Rats T3 T4 T. Protein Total SH- Protein.

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