Indian Journal of Animal Research

  • Chief EditorM. R. Saseendranath

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Indian Journal of Animal Research, volume 49 issue 1 (february 2015) : 187-190

Xanthine oxidase as a biochemical marker of dilated cardiomyopathy in dogs

P.S.L. Sesh*, P. Venkatesan, K. Jeyaraja, M. Chandrasekar, V. Pandiyan
1Department of Veterinary Biochemistry, Madras Veterinary College, Chennai-600 007, India.
Cite article:- Sesh* P.S.L., Venkatesan P., Jeyaraja K., Chandrasekar M., Pandiyan V. (2025). Xanthine oxidase as a biochemical marker of dilated cardiomyopathy in dogs . Indian Journal of Animal Research. 49(1): 187-190. doi: 10.5958/0976-0555.2015.00111.9.

ABSTRACT

Dilated cardiomyopathy occurs more frequently in large breed of dogs and the common form is the Idiopathic Dilated Cardiomyopathy. Xanthine oxidase is considered as one of the potent enzyme causing oxidative stress in the failing heart, and it uncouples cardiac energy consumption from cardiac contraction resulting in heart failure. In the present study xanthine oxidase activity was estimated in the serum of Dilated cardiomyopathy affected dogs and compared with that of healthy dogs serving as control. Similarly, other known cardiac enzyme markers like creatine kinase, aspartate transaminase and lactate dehydrogenase activities were also estimated. The results showed a 300% increase in the specific activity of xanthine oxidase and a 200% increase in the total activity of xanthine oxidase. This ind icates that measurement of xanthine oxidase activity can serve as an early biochemical marker for diagnosis of Dilated cardiomyopathy in canines.q

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