Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

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Indian Journal of Animal Research, volume 49 issue 4 (august 2015) : 498-502

Detection of exogenous Jaagsiekte sheep retrovirus in Turkey

Kezban Can-Sahna, Yesari Eroksuz, Engin Berber, Ibrahim Sozdutmaz
1Faculty of Veterinary Medicine, University of Firat, Elazig, Turkey.
Cite article:- Can-Sahna Kezban, Eroksuz Yesari, Berber Engin, Sozdutmaz Ibrahim (2024). Detection of exogenous Jaagsiekte sheep retrovirus in Turkey. Indian Journal of Animal Research. 49(4): 498-502. doi: 10.5958/0976-0555.2015.00053.9.

ABSTRACT

The aim of this study is to detect the exogenous Jaagsiekte sheep retrovirus (exJSRV) in suspected cases of ovine pulmonary adenocarcinoma (OPA) from the Eastern Anatolian region of Turkey. Pathological examination and PCR were carried out with the lung, lymph nodule, brain, heart and liver tissues of four sheep with suspected OPA. Histology of the lung sections indicated the well-circumscribed, multifocal and unencapsulated gray to white masses (arrows) on the parietal surface of medial and caudal lobes. exJSRV was detected in all tissue samples except for brain by nested polymerase chain reaction (nPCR). In addition to the nested-PCR results, the presence of exJSRV into the clinical samples was confirmed with sequencing of two PCR-positive products for OPAV. This report highlights the first presence of exJSRV in the sheep suspected with OPA in Turkey. Furthermore, the results provide supporting evidence for the metastasis of exJSRV in extra-thoracic tissues.

REFERENCES

  1. Arnaud, F., Murcia, P.R., and Palmarini, M. (2007). Mechanisms of late restriction induced by an endogenous retrovirus. J Virol, 81: 11441-11451.
  2. Beytut, E., Sözmen, M., and Erginsoy, S. (2009). Immunohistochemical detection of pulmonary surfactant proteins and retroviral antigens in the lungs of sheep with pulmonary adenomatosis. J Comp Path, 140: 43-53.
  3. De Las Heras, M., Gonzalez, L., and Sharp, J.M. (2003). Pathology of ovine pulmonary adenocarcinoma. Curr Top Microbiol Immunol, 275: 25-54.
  4. De Las Heras, M., Ortin, A., Salvatori, D., Villareal, M.P., Cousens, C., Ferrer, L.M., Cebrian, L.M., Jalon, J.A.G., Gonzalez, L., and Sharp, J.M.( 2005). A PCR technique for the detection of Jaagsiekte sheep retrovirus in the blood suitable for the screening of ovine pulmonary adenocarcinoma in field conditions. Res Vet Sci, 79: 259-264.
  5. DeMartini, J.C., Carlson, J.O., Leroux, C., Spencer, T., and Palmarini, M. (2003). Endogenous retroviruses related to jaagsiekte sheep retroviruses. Curr Top Microbiol Immunol, 275: 117-137.
  6. Garcia-Goti, M., Gonzalez, L., Cousens, C., Cortobarria, N., and Extramiana, A.B. (2000). Sheep pulmonary adenomatosis: Characterization of two pathological forms associated with Jaagsiekte retrovirus. J Comp Pathol, 122: 55-65.
  7. Grego, E., De Meneghi, D., Alvarez, V., Benito, A.A., and Munguijon, E. (2008). Colostrum and milk can transmit jaagsiekte retrovirus to lambs. Vet Microbiol, 130: 247-257.
  8. Hunter, A.R., and Munro, R. (1983). The diagnosis, occurrence and distribution of sheep pulmonary adenomatosis in Scotland 1975 to 1981. British Vet J, 139: 153-164.
  9. Minguijon, E., Gonzalez, L., De Las Heras, M., Gomez, N., Marcia-Goti, M., Juste, R.A., and Moreno, B. (2013). Pathological and aetiological studies in sheep exhibiting extrathoracic metastasis of ovine pulmonary adenocarcinoma. J Comp Pathol, 148: 71-78.
  10. Ortin, A., Minguijon, E., Dewar, P., Garcia, M., Ferrer, L.M., Palmarini, M., Gonzalez, L., Sharp, J.M., and De Las Heras, M. (1998). Lack of a specific immune response against recombinant capsid protein of Jaagsiekte sheep retrovirus in sheep and goats naturally affected by enzootic nasal tumour or sheep pulmonary adenomatosis. Vet Immun Immunopatho, 61: 229-237.
  11. Palmarini, M., Dewar, P., De Las Heras, M., Inglis, N.F., Dalziel, R.G., and Sharp, J.M. (1995). Epithelial tumour cells in the lung of sheep with pulmonary adenomatosis are major sites of replication for Jjaagsiekte retrovirus. J Gen Virol, 76: 2731-2737.
  12. Palmarini, M., Holland, M.J., Cousens, C., Dalziel, R.G., and Sharp, M. (1996). Jaagsiekte retrovirus establishes a disseminated infection of the lymphoid tissues of sheep affected by pulmonary adenomatosis. J Gen Virol, 77: 2991-2998.
  13. Palmarini, M., Sharp, J.M., De Las Heras, M., and Fan, H. (1999). Jaagsiekte sheep retrovirus is necessary and sufficient to induce a contagious lung cancer of sheep. J Virol, 73: 6964-6972.
  14. Palmarini, M., Gray, C.A., Carpenter, K., Fan, H., and Bazer, F.W. (2001). Expression of endogenous betaretroviruses in the ovine uterus: effects of neonatal age, estrous cycle, pregnancy and progesterone. J Virol, 75: 11319-11327.
  15. Salvatori, D., Gonzalez, L., Dewar, P., Cousens, C., De Las Heras, M., Dalziel, R.G., and Sharp, J.M. (2004). Successful induction of ovine pulmonary adenocarcinoma in lambs of different ages and detection of viraemia during preclinical period. J Gen Virol, 85: 3319-3324.
  16. Sambrook, J., Fritch, E.F., and Maniatis, T. (1989). Molecular Cloning: A Manual 2nd Ed., Cold Spring Harbor Laboratory Press, New York.
  17. Sharp, J.M., and DeMartini, J.C. (2003). Natural history of JSVR in sheep. Curr Top Microbiol Immunol, 275: 55-79.
  18. Sharp, J.M., and Herring, A.J. (1983). Sheep pulmonary adenomatosis: demonstration of a protein which cross-reacts with the major core proteins of Mason-Pfizer monkey virus and Mouse mammary tumor virus. J Gen Virol, 64: 2323-2328.
  19. Spencer, T.E., Mura, M., Gray, C.A., Griebel, P.J., and Palmarini, M. (2003). Receptor usage and fetal expression of ovine endogenous betaretrovirus: implications for coevolution of endogenous and exogenous retroviruses. J Virol, 77: 749-753.
  20. Summers, C., Neill, W., Dewar, P., Gonzalez, L., and Van der Molen, R. (2002). Systemic immune responses following infection with Jaagsiekte sheep retrovirus and the terminal stages of ovine pulmonary adenocarcinoma. J Gen Virol, 83: 1753-1757.
  21. Voigt, K., Brügmann, M., Huber, K., Dewar, P., Cousens, C., Hall, M., Sharp, J.M., and Granter, M. (2007). PCR examination of bronchoalveolar lavage samples is a useful tool in pre-clinical diagnosis of ovine pulmonary adenocarcinoma (Jaagsiekte). Res Vet Sci, 83: 419-427.
  22. Wright, D.K., and Mannos, M. (1990). Sample preparation from paraffin-embedded tissues. In: PCR Protocols. A Guide to Methods and Applications, Academic Press, San Diego, pp:153-157.
  23. York, D.F., Vigne, R., Verwoerd, D.W., and Querat, G. (1992). Nucleotide sequence of jaagsiekte retrovirus, an exogenous and endogenous type D and B retrovirus of sheep and goats. J Virol, 66: 4930-493.
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