Biochemical and leucocytic response study of herbal immunomodulators against levamisole in Toxocara canis infected mice

DOI: 10.5958/0976-0555.2015.00141.7    | Article Id: B-2638 | Page : 336-342
Citation :- Biochemical and leucocytic response study of herbal immunomodulators against levamisole in Toxocara canis infected mice.Indian Journal Of Animal Research.2015.(49):336-342
Aman D. Moudgil*, S. Mittra, D. Sen, R. K. Agnihotri and D. Sharma moudgil.aman@gmail.com
Address : Department of Veterinary Parasitology, Dr. G. C. Negi College of Veterinary and Animal Sciences, CSK Himachal Pradesh Krishi Vishwavidyalaya, Palampur 176 062, India.

Abstract

Toxocara canis owns an exceptional ability to withstand host’s immune system by encystment of larval stages into host’s tissue and thus, paving way for anthelmintic ineffectiveness against the larval stages of the parasite. The aim of the present study was to evaluate the effect of three herbal (methanolic extracts of Hippophae rhamnoides, H. salicifolia and Piper longum) and one allopathic (levamisole) immunomodulators on the migratory behaviour of T. canis larvae in tissues of Swiss albino mice, experimentally infected with T. canis embryonated eggs on day 14 of immunomodulatory medication. On the basis of biochemical and leukocyte observations on days 14 and 28 post infection, H. salicifolia and H. rhamnoides were recorded as superior immunomodulators followed by levamisole and Piper longum in Swiss albino mice.

Keywords

Hippophae rhamnoides Hippophae salicifolia Immunomodulators Levamisole Piper longum Swiss albino mice Toxocara canis.

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