Published In
Indian Journal of Animal Research
Article Metrics

0
Views
0
Citations
Reviewed By
In this Article
APC
APC cover the cost of turning a manuscript into a published manuscript through peer-review process, editorial work as well as the cost of hosting, distributing, indexing and promoting the manuscript.
Publish With US
Submit your manuscript through user friendly platform and acquire the maximum impact for your research by publishing with ARCC Journals.
Become a Reviewer/Member
Join our esteemed reviewers panel and become an editorial board member with international experts in the domain of numerous specializations.
Open Access
Filling the gap between research and communication ARCC provide Open Access of all journals which empower research community in all the ways which is accessible to all.
Products and Services
We provide prime quality of services to assist you select right product of your requirement.
Support and Policies
Finest policies are designed to ensure world class support to our authors, members and readers. Our efficient team provides best possible support for you.
Follow us
volume 49 issue 4 (august 2015) : 491-497, Doi: 10.5958/0976-0555.2015.00162.4
Potential of methanolic extract of leaves of Hamiltonia suaveolens Roxb as the wound healer in rat
1Post Graduate Department of Zoology, Animal Physiology, Moolji Jaitha College,
North Maharashtra University, Jalgaon 425 002, India.
Submitted|
First Online |
Cite article:- Chopda Kumar Manoj, Mahajan Namrata, Bhat Jaydeep, Bhirud Mahesh, Mahajan Raghunath (2025). Potential of methanolic extract of leaves of Hamiltonia suaveolens Roxb as the wound healer in rat. Indian Journal of Animal Research. 49(4): 491-497. doi: 10.5958/0976-0555.2015.00162.4.
ABSTRACT
Wound healing activity of methanolic extract of leaves of Hamiltonia suaveolens Roxb was assessed by using excision, incision and dead space wound model in Wistar rat. The animals were divided into five groups (n=6) and labeled as control; placebo; standard and experimental groups. Ointment of the methanolic extract at a dose 2.5% and 5% w/w were prepared and applied topically. The healing of the wound was assessed by the rate of wound contraction, period of epithelialization, skin breaking strength, biochemical profile and histopathology of granuloma tissue and Wound Image Analysis Software – WITA used for the first time. Animals were treated with the methanolic extract at a dose 5% exhibited 98.04% reduction in wound area 20th day, compared to control (93.82%). In incision wound model, tensile strength of healing tissue after treatment was found to be significantly higher compared to control group. The hydroxyproline (108.7 mg/g of tissue), ascorbic acid (50.69 mg/g of tissue) and glucosamine (33.22 mg/g of tissue) content from the wound area found significantly increased in treated animals at 5% concentration of methanolic extract as compared to control group of animals. Histological analysis revealed swift restoration of wound healing.
KEYWORDS
REFERENCES
- Chandra, P., Yadav, E., Mani, M., Ghosh, A. K., & Sachan, N. (2013). Protective effect of Lygodium flexuosum (family: Lygodiaceae) against excision, incision and dead space wounds models in experimental rats. Toxicol Ind Health. http://dx.doi.org/10.1177/0748233712471704.
- Charde, M. S., Fulzele, S. V., Satturwar, P. M., Joshi, S. B. and Kasture, A. V. (2006). The wound healing and Anti-inflammatory potential of Madhu ghrita. Indian J Pharmace Sci. 68(1):26-31.
- Chopda, M. Z. (2009). Studies on wound healing agents of plant origin. Ph.D. thesis, North Maharashatra University, Jalgaon.
- Chopda, M. Z. and Mahajan, R. T. (2009). The wound healing plants of Jalgaon District, Maharashatra State, India. Ethanobotanical leaflets. 13:1-32.
- Chopda, M. Z., Patole, S. S., Mahajan, R. T. (2010). Wound healing activity of Sphaeranthus indicus (linn) in Albino rats. Bioresources for Rural Livelihood, (Narendra Publishing House, New Delhi). 239-242.
- Chopra, R. N., Nayar, S. C., Chopra, I. C. (1986). Glossary of Indian Medicinal Plants, (CSIR Publication, New Delhi).
- Harborne, J. B. (1986). Phytochemical Methods, A Guide to Modern Techniques of Plant Analysis, second edition, Chapman and Hill, London.
- Karodi, R., Jadhav, M., Rub, R. and Bafna, A. (2009). Evaluation of the wound healing activity of a crude extract of Rubia cordifolia L. (Indian madder) in mice. International J Applied Research in Natural Products. 2(2):12-18.
- Karou, S. D., Tchacondo, T., Ilboudo, D. P. and Simpore, J. (2011). Sub-Saharan Rubiaceae: a review of their traditional uses, phytochemistry and biological activities. Pak J Biol Sci. 14(3):149-169.
- Lee, K. H. (1968). Study on the Mechanism of action of salycylates II. Retardation of wound healing by aspirin. J Pharma Sci. 57:1042-1043.
- Leite, S. N., Palhano, G., Almeida, S. and Biavattii, M. W. (2002). Wound healing activity and systemic effects of Vernonia scorpioides gel in guinea pig. Fitoterapia. 73: 496-500.
- Raghuramulu, N. K., Nair M. and Kalyanasundaram, S. (2003). A Manual of Laboratory Techniques, (National Institute of Nutrition, Hyderabad).
- Rashed, A. N., Afifi, F. U. and Disi, A. M. (2003). Simple evaluation of the wound healing activity of a crude extract of Portulaca oleracea L. growing in Jordan. J Ethnopharmacology 88:131-136.
- Satyavati, G. V., Tandon, N. and Sharma, M. (1989). Indigenous plant drugs for Diabetes Mellitus. Diabetes Bulleta. 181.
- Shukla, A., Rasik, A. M., Jain, G. K., Shankar, R., Kulshrestha, D. K. and Dhavan, B. N. (1999). In vitro and in vivo the wound healing activity of asiaticoside isolated from Centella asiatica, J ethanopharmacol. 65(1):1-11.
- Udupa, S. L., Udupa, A. L. and Kulkarni, D. R. (1991). Influence of Tridax procumbens on lysyl oxidase activity and wound healing. Planta Medica. 57(4):325-327.
- Udupa, S. L., Udupa, A. L. and Kulkarni, D. R. (1994). Anti-inflammatory and the wound healing properties of Aloe vera. Fitoterapia. LXV(2):141-145.
Disclaimer :
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Copyright :
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
In this Article
APC
APC cover the cost of turning a manuscript into a published manuscript through peer-review process, editorial work as well as the cost of hosting, distributing, indexing and promoting the manuscript.
Publish With US
Submit your manuscript through user friendly platform and acquire the maximum impact for your research by publishing with ARCC Journals.
Become a Reviewer/Member
Join our esteemed reviewers panel and become an editorial board member with international experts in the domain of numerous specializations.
Open Access
Filling the gap between research and communication ARCC provide Open Access of all journals which empower research community in all the ways which is accessible to all.
Products and Services
We provide prime quality of services to assist you select right product of your requirement.
Support and Policies
Finest policies are designed to ensure world class support to our authors, members and readers. Our efficient team provides best possible support for you.
Follow us
Published In
Indian Journal of Animal Research