NEPHROTOXIC ACTIVITY OF METHANOLIC EXTRACT OF SAPINDUS LAURIFOLIUS IN RATS

Citation :- NEPHROTOXIC ACTIVITY OF METHANOLIC EXTRACT OF SAPINDUS LAURIFOLIUS IN RATS.Indian Journal Of Animal Research.2014.(48):50-54

C.N. Santhosh Kumar, N.B. Shridhar*, Ambika Das, M.L. Satyanarayana and C. Ansar Kamran

C.N. Santhosh Kumar, N.B. Shridhar*, Ambika Das, M.L. Satyanarayana and C. Ansar Kamran sridhar_vet@rediffmail.com
Address : Department of Veterinary Pharmacology and Toxicology, Veterinary College, Hebbal, Bangalore - 560 024, India

Abstract

The Sapindus laurifolius methanolic leaf extract was evaluated for phytochemical analysis, acute and repeated dose 28-day oral toxicity study in Wistar rats. The phytochemical analysis revealed the presence of saponins, flavanoids and glycosides. In acute toxicity study, S. laurifolius leaf extract was found to be non toxic up to 2 g/kg. In repeated dose 28-day oral toxicity, leaf extract administered at the doses 50, 200 and 800 mg/kg and limit dose of 1000 mg/kg. There was a significant (Peen stopped or animals may require still longer duration for recovery.

Keywords

Sapindus laurifolius leaf extract Wistar Rats Phytochemical analysis Saponin   Hepatotoxicity Nephrotoxicity.

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