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Current IssueEditorial BoardOnline First ArticlesArchive

volume 48 issue 1 (february 2014) : 50-54,   Doi: 10.5958/j.0976-0555.48.1.010

NEPHROTOXIC ACTIVITY OF METHANOLIC EXTRACT OF SAPINDUS LAURIFOLIUS IN RATS

C
C.N. Santhosh Kumar
N
N.B. Shridhar*
A
Ambika Das
M
M.L. Satyanarayana
C
C. Ansar Kamran
1Department of Veterinary Pharmacology and Toxicology, Veterinary College, Hebbal, Bangalore - 560 024, India
Cite article:- Kumar Santhosh C.N., Shridhar* N.B., Das Ambika, Satyanarayana M.L., Kamran Ansar C. (2025). NEPHROTOXIC ACTIVITY OF METHANOLIC EXTRACT OF SAPINDUS LAURIFOLIUS IN RATS. Indian Journal of Animal Research. 48(1): 50-54. doi: 10.5958/j.0976-0555.48.1.010.

ABSTRACT

The Sapindus laurifolius methanolic leaf extract was evaluated for phytochemical analysis, acute and repeated dose 28-day oral toxicity study in Wistar rats. The phytochemical analysis revealed the presence of saponins, flavanoids and glycosides. In acute toxicity study, S. laurifolius leaf extract was found to be non toxic up to 2 g/kg. In repeated dose 28-day oral toxicity, leaf extract administered at the doses 50, 200 and 800 mg/kg and limit dose of 1000 mg/kg. There was a significant (Peen stopped or animals may require still longer duration for recovery.

REFERENCES

  1. Cheeke, P.R., (1998). Toxins intrinsic to forages. In: Cheeke, P.R. (Ed.), Natural Toxicants in Feed, Forages and Poisonous Plants. Interstate Publishers, Danville, p. 275-324
  2. Cherian, K.M., Gandhi, V.M. and Mulky, M., (1996). Toxicological evaluation of Mowrah (Madhuca latifolia) seed material. Indian. J. Exp. Biol., 34: 61-65
  3. Diwan, F.H., Abdel-Hassan, I.A. and Mohammed, S.T., (2000). Effect of saponin on mortality, histopathological changes in mice. East Mediterr. Health J., 6(3): 345-351
  4. Jeyabalan, S. and Palayan, M., (2009). CNS activity of the methanol extracts of Sapindus emarginatus in experimental animal models. J. Sci. Res., 1 (3): 583-593
  5. Kasai, R., Fujino, H., Kuzuki, T., Wong, W.H., Goto, C., Yata, N., Tanaka, O., Yasuhara, F. and Yamaguchi, S., (1986). Acyclic sesquiterpene oligoglycosides from pericarps of Sapindus mukurossi. Phytochem., 25: 871-876
  6. Kishore, D.V., Jennifer, P. and Mini, K.V., (2011). Antiulcer activity of methanolic and aqueous extracts of S. trifoliatus leaves. Int. J. Pharmaceut. Sci. Rev. Res., 6(1): 25-26
  7. Shridhar, N.B. and Narayana, K., (2004). Toxicity studies of Sapindus laurifolis in cross bred male calves: Paper presented in 23rd Conference of Society of Toxicology held in Lucknow on 26-8-2004: p. 24
  8. Wagner, H., Bladt, S. and Zgainski, E.M., (1984). Plant drug analysis; A thin layer chromatography atlas. Edn. 2nd., Springer-Verlag: Heidelberg, New York., p. 50-244
  9. Witthawaskul, P., Panthong, A., Kanjanapothi, D., Taesothikul, T. and Lertprasertsuke, N., (2003). Acute and subacute toxicities of the saponin mixture isolated from Schefflera leucantha leaves. J. Ethnopharmacol., 89(1): 115- 121
  10. Wisloff, H., Ottesen, N., Hovig, T., (2003). Narthecium ossifragum (L.) huds causes kidney damage in goats: morphologic and functional effects. Vet. Pathol., 40: 317-327
  11. Wisloff, H., Uhlig, S., Scheie, E., Loader, J., Wilkins, A. and Yen, A.F., (2008). Toxicity testing of saponin containing Yucca Schidigera Roetzl. juice in relation to hepato- and and nephrotoxicity of Narthecium Ossifragum (L.) huds. Toxicon., 51(1): 140-150
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Indian Journal of Animal Research
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    volume 48 issue 1 (february 2014) : 50-54,   Doi: 10.5958/j.0976-0555.48.1.010

    NEPHROTOXIC ACTIVITY OF METHANOLIC EXTRACT OF SAPINDUS LAURIFOLIUS IN RATS

    C
    C.N. Santhosh Kumar
    N
    N.B. Shridhar*
    A
    Ambika Das
    M
    M.L. Satyanarayana
    C
    C. Ansar Kamran
    1Department of Veterinary Pharmacology and Toxicology, Veterinary College, Hebbal, Bangalore - 560 024, India
    Cite article:- Kumar Santhosh C.N., Shridhar* N.B., Das Ambika, Satyanarayana M.L., Kamran Ansar C. (2025). NEPHROTOXIC ACTIVITY OF METHANOLIC EXTRACT OF SAPINDUS LAURIFOLIUS IN RATS. Indian Journal of Animal Research. 48(1): 50-54. doi: 10.5958/j.0976-0555.48.1.010.

    ABSTRACT

    The Sapindus laurifolius methanolic leaf extract was evaluated for phytochemical analysis, acute and repeated dose 28-day oral toxicity study in Wistar rats. The phytochemical analysis revealed the presence of saponins, flavanoids and glycosides. In acute toxicity study, S. laurifolius leaf extract was found to be non toxic up to 2 g/kg. In repeated dose 28-day oral toxicity, leaf extract administered at the doses 50, 200 and 800 mg/kg and limit dose of 1000 mg/kg. There was a significant (Peen stopped or animals may require still longer duration for recovery.

    REFERENCES

    1. Cheeke, P.R., (1998). Toxins intrinsic to forages. In: Cheeke, P.R. (Ed.), Natural Toxicants in Feed, Forages and Poisonous Plants. Interstate Publishers, Danville, p. 275-324
    2. Cherian, K.M., Gandhi, V.M. and Mulky, M., (1996). Toxicological evaluation of Mowrah (Madhuca latifolia) seed material. Indian. J. Exp. Biol., 34: 61-65
    3. Diwan, F.H., Abdel-Hassan, I.A. and Mohammed, S.T., (2000). Effect of saponin on mortality, histopathological changes in mice. East Mediterr. Health J., 6(3): 345-351
    4. Jeyabalan, S. and Palayan, M., (2009). CNS activity of the methanol extracts of Sapindus emarginatus in experimental animal models. J. Sci. Res., 1 (3): 583-593
    5. Kasai, R., Fujino, H., Kuzuki, T., Wong, W.H., Goto, C., Yata, N., Tanaka, O., Yasuhara, F. and Yamaguchi, S., (1986). Acyclic sesquiterpene oligoglycosides from pericarps of Sapindus mukurossi. Phytochem., 25: 871-876
    6. Kishore, D.V., Jennifer, P. and Mini, K.V., (2011). Antiulcer activity of methanolic and aqueous extracts of S. trifoliatus leaves. Int. J. Pharmaceut. Sci. Rev. Res., 6(1): 25-26
    7. Shridhar, N.B. and Narayana, K., (2004). Toxicity studies of Sapindus laurifolis in cross bred male calves: Paper presented in 23rd Conference of Society of Toxicology held in Lucknow on 26-8-2004: p. 24
    8. Wagner, H., Bladt, S. and Zgainski, E.M., (1984). Plant drug analysis; A thin layer chromatography atlas. Edn. 2nd., Springer-Verlag: Heidelberg, New York., p. 50-244
    9. Witthawaskul, P., Panthong, A., Kanjanapothi, D., Taesothikul, T. and Lertprasertsuke, N., (2003). Acute and subacute toxicities of the saponin mixture isolated from Schefflera leucantha leaves. J. Ethnopharmacol., 89(1): 115- 121
    10. Wisloff, H., Ottesen, N., Hovig, T., (2003). Narthecium ossifragum (L.) huds causes kidney damage in goats: morphologic and functional effects. Vet. Pathol., 40: 317-327
    11. Wisloff, H., Uhlig, S., Scheie, E., Loader, J., Wilkins, A. and Yen, A.F., (2008). Toxicity testing of saponin containing Yucca Schidigera Roetzl. juice in relation to hepato- and and nephrotoxicity of Narthecium Ossifragum (L.) huds. Toxicon., 51(1): 140-150
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