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Current IssueEditorial BoardOnline First ArticlesArchive

volume 48 issue 5 (october 2014) : 464-468,   Doi: 10.5958/0976-0555.2014.00012.0

PROTECTION OF SALVIA MILTIORRHIZA AGAINST ACUTE SODIUM NITRITE POISONING IN MICE

X
Xiaomei Lu*
Z
Zhijie Lai
M
Meng jia Du
1Department of Pathophysiology, College of Basic Medical Sciences, China Medical University, ShenYang, 110 001, China
Cite article:- Lu* Xiaomei, Lai Zhijie, Du jia Meng (2025). PROTECTION OF SALVIA MILTIORRHIZA AGAINST ACUTE SODIUM NITRITE POISONING IN MICE. Indian Journal of Animal Research. 48(5): 464-468. doi: 10.5958/0976-0555.2014.00012.0.

ABSTRACT

The present study evaluated the protection of Salvia miltiorrhiza injection against acute sodium nitrite poisoning in mice. Forty male C57mice were randomly divided into control group, sodium nitrite poisoning group (SN), Methylene blue (MB) and Salvia miltiorrhizae (SM) group. In SN, MB and SM group, 200 mg/kg sodium nitrite was injected intraperitoneal. Mice in MB and SM group were given 1.5mg/kg Methylene blue and 0.2ml Salvia miltiorrhiza injection immediately after sodium nitrite injection respectively. Mice in SN and SM group demonstrated higher blood methemoglobin and Serum TNFá and IL-6 but lower IL-10 levels than control group (P

REFERENCES

  1. Brown C., Bowling M.(2013). Methemoglobinemia in bronchoscopy: a case series and a review of the literature. J Bronchology Interv Pulmonol 20:241-246.
  2. Chen S., Liu X.M.(2006). Effect of Salvia miltiorrhiza injection on hyperpolarization activated current channels in dorsal root ganglion neurons of rats. Yao Xue Xue Bao 41: 1038-1043.
  3. Gautami S., Rao R.N., Raghuram T.C., Rajagopalan S., Bhat R.V. (1995). Accidental acute fatal sodium nitrite poisoning. J Toxicol Clin Toxicol 33: 131-133.
  4. Hall N.M., Jones F.J., Ainsworth C.R., Fincher R.K. (2013). Methemoglobinemia in patients undergoing esophagogastroduodenoscopy: a randomized controlled trial. Mil Med 178:701-704.
  5. Han J.Y., Fan J.Y., Horie Y., Miura S., Cui D.H., Ishii H., Hibi T., Tsuneki H., Kimura I. (2008). Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion. Pharmacol Ther 117: 280-295.
  6. Hassan H.A., Hafez H.S., Zeghebar F.E. (2010). Garlic oil as a modulating agent for oxidative stress and neurotoxicity induced by sodium nitrite in male albino rats. Food Chem Toxicol 48: 1980-1985.
  7. Jing Y.L., Wang Y.L., Yin D.D., Cao B.H., Zhang W., Geng F., Sun N. (2010). Protective effects and pathogenesis of complex salvin miltiorrhiza on acute mercury poisoning in rabbits. Zhongguo Ying Yong Sheng Li Xue Za Zhi 26:341-344.
  8. Luca D., Luca V., Cotor F., Raileanu L. (1987). In vivo and in vitro cytogenetic damage induced by sodium nitrite. Mutat Res 189: 333-339.
  9. Lukin-Butenko G.A., Luzhnikov E.A., Koldaev A.A. (1983). Hyperbaric oxygenation in the complex treatment of acute poisoning with methemoglobin formers. Klin Med 61: 121-125.
  10. Ni J.X., Gao S.H. (2012). Understanding the viscera-related theory that the lung and large intestine are exterior-interiorly related. J Tradit Chin Med 32: 293-298.
  11. Singh R., Vinayagam S., Vajifdar H. (2012). Methemoglobinemia as a result of accidental lacquer thinner poisoning. Indian J Crit Care Med 16:44-47.
  12. Wang R., Yu X.Y., Guo Z.Y., Wang Y.J., Wu Y., Yuan Y.F. (2012). Inhibitory effects of salvianolic acid B on CCl4- induced hepatic fibrosis through regulating NF-êB/IêBá signaling. J Ethnopharmacol 144:592-598.
  13. Xia Z., Gu J., Ansley D.M., Xia F., Yu J. (2003). Antioxidant therapy with Salvia miltiorrhiza decreases plasma endothelin- 1 and thromboxane B2 after cardiopulmonary bypass in patients with congenital heart disease. J Thorac Cardiovasc Surg 126: 1404-1410.
  14. Xie T.P., Zhao Y.F., Chen L.Q., Zhu Z.J., Hu Y., Yuan Y. (2011). Long-term exposure to sodium nitrite and risk of esophageal carcinoma, a cohort study for 30 years. Dis Esophagus 24: 30-32.
  15. Yu J., Fei J., Azad J., Gong M., Lan Y., Chen G.. (2013). Myocardial protection by salvia miltiorrhiza injection in streptozotoc-ininduced diabetic rats through attenuation of expression of thrombospondin-1 and transforming growth factor-â1. J Int Med Res 40: 1016-1024.
  16. Zhao Y., Yin Y., Lü X.J., Feng P., Liu J., Sha J.P., Lei B.J. (2004). Effects of Radix Salviae Miltiorrhizae on the PMN- EC adhesion in vitro at the early stage of endotoxemia. Sichuan Da Xue Xue Bao Yi Xue Ban 35: 320-322, 346.
  17. Zheng L.W., Hua H., Cheung L.K. (2011). Traditional Chinese medicine and oral diseases, today and tomorrow. Oral Dis 17:7-12.
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    volume 48 issue 5 (october 2014) : 464-468,   Doi: 10.5958/0976-0555.2014.00012.0

    PROTECTION OF SALVIA MILTIORRHIZA AGAINST ACUTE SODIUM NITRITE POISONING IN MICE

    X
    Xiaomei Lu*
    Z
    Zhijie Lai
    M
    Meng jia Du
    1Department of Pathophysiology, College of Basic Medical Sciences, China Medical University, ShenYang, 110 001, China
    Cite article:- Lu* Xiaomei, Lai Zhijie, Du jia Meng (2025). PROTECTION OF SALVIA MILTIORRHIZA AGAINST ACUTE SODIUM NITRITE POISONING IN MICE. Indian Journal of Animal Research. 48(5): 464-468. doi: 10.5958/0976-0555.2014.00012.0.

    ABSTRACT

    The present study evaluated the protection of Salvia miltiorrhiza injection against acute sodium nitrite poisoning in mice. Forty male C57mice were randomly divided into control group, sodium nitrite poisoning group (SN), Methylene blue (MB) and Salvia miltiorrhizae (SM) group. In SN, MB and SM group, 200 mg/kg sodium nitrite was injected intraperitoneal. Mice in MB and SM group were given 1.5mg/kg Methylene blue and 0.2ml Salvia miltiorrhiza injection immediately after sodium nitrite injection respectively. Mice in SN and SM group demonstrated higher blood methemoglobin and Serum TNFá and IL-6 but lower IL-10 levels than control group (P

    REFERENCES

    1. Brown C., Bowling M.(2013). Methemoglobinemia in bronchoscopy: a case series and a review of the literature. J Bronchology Interv Pulmonol 20:241-246.
    2. Chen S., Liu X.M.(2006). Effect of Salvia miltiorrhiza injection on hyperpolarization activated current channels in dorsal root ganglion neurons of rats. Yao Xue Xue Bao 41: 1038-1043.
    3. Gautami S., Rao R.N., Raghuram T.C., Rajagopalan S., Bhat R.V. (1995). Accidental acute fatal sodium nitrite poisoning. J Toxicol Clin Toxicol 33: 131-133.
    4. Hall N.M., Jones F.J., Ainsworth C.R., Fincher R.K. (2013). Methemoglobinemia in patients undergoing esophagogastroduodenoscopy: a randomized controlled trial. Mil Med 178:701-704.
    5. Han J.Y., Fan J.Y., Horie Y., Miura S., Cui D.H., Ishii H., Hibi T., Tsuneki H., Kimura I. (2008). Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion. Pharmacol Ther 117: 280-295.
    6. Hassan H.A., Hafez H.S., Zeghebar F.E. (2010). Garlic oil as a modulating agent for oxidative stress and neurotoxicity induced by sodium nitrite in male albino rats. Food Chem Toxicol 48: 1980-1985.
    7. Jing Y.L., Wang Y.L., Yin D.D., Cao B.H., Zhang W., Geng F., Sun N. (2010). Protective effects and pathogenesis of complex salvin miltiorrhiza on acute mercury poisoning in rabbits. Zhongguo Ying Yong Sheng Li Xue Za Zhi 26:341-344.
    8. Luca D., Luca V., Cotor F., Raileanu L. (1987). In vivo and in vitro cytogenetic damage induced by sodium nitrite. Mutat Res 189: 333-339.
    9. Lukin-Butenko G.A., Luzhnikov E.A., Koldaev A.A. (1983). Hyperbaric oxygenation in the complex treatment of acute poisoning with methemoglobin formers. Klin Med 61: 121-125.
    10. Ni J.X., Gao S.H. (2012). Understanding the viscera-related theory that the lung and large intestine are exterior-interiorly related. J Tradit Chin Med 32: 293-298.
    11. Singh R., Vinayagam S., Vajifdar H. (2012). Methemoglobinemia as a result of accidental lacquer thinner poisoning. Indian J Crit Care Med 16:44-47.
    12. Wang R., Yu X.Y., Guo Z.Y., Wang Y.J., Wu Y., Yuan Y.F. (2012). Inhibitory effects of salvianolic acid B on CCl4- induced hepatic fibrosis through regulating NF-êB/IêBá signaling. J Ethnopharmacol 144:592-598.
    13. Xia Z., Gu J., Ansley D.M., Xia F., Yu J. (2003). Antioxidant therapy with Salvia miltiorrhiza decreases plasma endothelin- 1 and thromboxane B2 after cardiopulmonary bypass in patients with congenital heart disease. J Thorac Cardiovasc Surg 126: 1404-1410.
    14. Xie T.P., Zhao Y.F., Chen L.Q., Zhu Z.J., Hu Y., Yuan Y. (2011). Long-term exposure to sodium nitrite and risk of esophageal carcinoma, a cohort study for 30 years. Dis Esophagus 24: 30-32.
    15. Yu J., Fei J., Azad J., Gong M., Lan Y., Chen G.. (2013). Myocardial protection by salvia miltiorrhiza injection in streptozotoc-ininduced diabetic rats through attenuation of expression of thrombospondin-1 and transforming growth factor-â1. J Int Med Res 40: 1016-1024.
    16. Zhao Y., Yin Y., Lü X.J., Feng P., Liu J., Sha J.P., Lei B.J. (2004). Effects of Radix Salviae Miltiorrhizae on the PMN- EC adhesion in vitro at the early stage of endotoxemia. Sichuan Da Xue Xue Bao Yi Xue Ban 35: 320-322, 346.
    17. Zheng L.W., Hua H., Cheung L.K. (2011). Traditional Chinese medicine and oral diseases, today and tomorrow. Oral Dis 17:7-12.
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