Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

  • Print ISSN 0367-6722

  • Online ISSN 0976-0555

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Indian Journal of Animal Research, volume 55 issue 7 (july 2021) : 791-795

Potential Effect of β-casomorphin-7 on Lymphocyte and TLR\NF-κB Signaling Pathway in Intestinal Mucosa of Aged Mice

Hong Yin, Xiaqing Su, Jijie Liu, Lihua Li, Ying Tian, Jing Peng
1School of Tourism cooking and Food science and engineering, Yangzhou University, Yangzhou 225000, China.
Cite article:- Yin Hong, Su Xiaqing, Liu Jijie, Li Lihua, Tian Ying, Peng Jing (2020). Potential Effect of β-casomorphin-7 on Lymphocyte and TLR\NF-κB Signaling Pathway in Intestinal Mucosa of Aged Mice. Indian Journal of Animal Research. 55(7): 791-795. doi: 10.18805/ijar.B-1215.
The effect of â-Casomorphin-7 on intestinal mucosal immunity was investigated in aged mice. Mice were treated without or with different doses of â-Casomorphin-7 for 30 days. All mice were sacrificed and intestinal mucosa samples collection at the end of the experiment. Histopathological studies showed the tissue protective role of â-Casomorphin-7 in aged mice. The number of duodenal and jejunal epithelial lymphocytes decreased significantly (P<0.05). The doses of duodenal and jejunal epithelial lymphocytes in mice were significantly (P<0.05) increased in each dose group. The relative expression of TLR4, TRAF6 and NF-êB in the intestinal mucosa of the elderly model group was lower than that of the young control group. The low and middle dose groups significantly(P<0.05) up-regulated the relative expression of TLR4, TRAF6 and NF-êB.The results suggest that â-Casomorphin-7 can improved intestinal mucosal immune decline likely through balancing TLR4\NF-êB signaling pathway. 
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