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Potential Effect of β-casomorphin-7 on Lymphocyte and TLR\NF-κB Signaling Pathway in Intestinal Mucosa of Aged Mice

DOI: 10.18805/ijar.B-1215    | Article Id: B-1215 | Page : 791-795
Citation :- Potential Effect of β-casomorphin-7 on Lymphocyte and TLR\NF-κB Signaling Pathway in Intestinal Mucosa of Aged Mice.Indian Journal of Animal Research.2021.(55):791-795
Hong Yin, Xiaqing Su, Jijie Liu,  Lihua Li, Ying Tian, Jing Peng yinh@yzu.edu.cn
Address : School of Tourism cooking and Food science and engineering, Yangzhou University, Yangzhou 225000, China.
Submitted Date : 19-10-2019
Accepted Date : 6-12-2019

Abstract

The effect of â-Casomorphin-7 on intestinal mucosal immunity was investigated in aged mice. Mice were treated without or with different doses of â-Casomorphin-7 for 30 days. All mice were sacrificed and intestinal mucosa samples collection at the end of the experiment. Histopathological studies showed the tissue protective role of â-Casomorphin-7 in aged mice. The number of duodenal and jejunal epithelial lymphocytes decreased significantly (P<0.05). The doses of duodenal and jejunal epithelial lymphocytes in mice were significantly (P<0.05) increased in each dose group. The relative expression of TLR4, TRAF6 and NF-êB in the intestinal mucosa of the elderly model group was lower than that of the young control group. The low and middle dose groups significantly(P<0.05) up-regulated the relative expression of TLR4, TRAF6 and NF-êB.The results suggest that â-Casomorphin-7 can improved intestinal mucosal immune decline likely through balancing TLR4\NF-êB signaling pathway. 

Keywords

Intestinal mucosal immune NF-κB TLR4 β-casomorphin-7

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