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Research Article

volume 54 issue 12 (december 2020) : 1486-1489,   Doi: 10.18805/ijar.B-1150

Renal Damage Induced by Myocardial Ischemia Reperfusion in Mouse: Role of Oxidative Stress

X
Xue Tong
H
Hong Zhao
X
Xiaomei Lu
1Department of Functional Experiment No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province, P.R. China.
Cite article:- Tong Xue, Zhao Hong, Lu Xiaomei (2019). Renal Damage Induced by Myocardial Ischemia Reperfusion in Mouse: Role of Oxidative Stress. Indian Journal of Animal Research. 54(12): 1486-1489. doi: 10.18805/ijar.B-1150.

ABSTRACT

The aim of this study was to investigate whether oxidative stress has a role in myocardial ischemia reperfusion induced renal damage. The 30 male C57 mice were divided into control group, myocardial ischemia reperfusion (MIR) group and MnTBAP treatment group. In MIR group, the left coronary artery was occluded for 45minutes and reperfusion for 4 weeks. The same procedure was used for the MnTBAP group, with the additional step of MnTBAP (10mg/kg) administered intraperitoneally for 28 days. Before surgery and 4 weeks later, transthoracic echocardiography was performed and urine protein and albumin were measured. At the end of the time, mice were sacrified and kidneys collected for ROS and fibrosis analysis. The plasma was collected for BUN and SCR determination. It was observed that MIR decreased renal function and increased production of ROS, compelled with renal fibrosis. Administration of MnTBAP reduced production of ROS and renal fibrosis and increased renal function. These findings suggest that the MIR plays a causal role in causing renal injury and the MnTBAP exerts renal-protective effects, probably by its antioxidant activities.

REFERENCES

  1. Coresh, J., Astor, B.C., Greene, T., Eknoyan, G., Levey, A.S. (2003). Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis. 41:1-12.
  2. Guazzi, M. V.A., Labate, V., Arena, R. (2012). Treatment for pulmonary hypertension of left Heart disease. Curr Treat Options Cardiovasc Med. 14:319-327.
  3. Hamza, R.G., Shahat, A.N.E., Al-seeni, M.N. (2019). Studying the antioxidant role of mushroom against hazards of gamma radiation exposure in male rats.Indian Journal of Animal Research. DOI:10.18805/ijar.B-387.
  4. Ilhan, B.D., Ibrahim, K., Omer, E.Y., Metin, I., Serkan, K., Ferda, K.C., Resit, C., Aziz, I.C., Murat, C., Durdu, A. (2019). The effect of nizatidine on ovarian ischaemia/reperfusion injury in rats. Indian Journal of Animal Research. DOI:10.18805/ijar.B-934
  5. Indhu, M.S., Sesh, P.S.L., Loganathasamy, K., Jeyaraja, K., Padmanath, K., Pandiyan, V. (2019). Analysis of certain blood biochemical parameters in relation to oxidative stress in chronic mitral valve insufficiency of dogs with heart failure. Indian Journal of Animal Research. DOI:10.18805/ijar.B-3632.
  6. Maki, T., Nasa, Y., Tanonaka, K., Takahashi, M., Takeo, S. (2003). Beneficial effects of sampatrilat, a novel vasopeptidase inhibitor, on cardiac remodeling and function of rats with chronic heart failure following left coronary artery ligation. J Pharmacol Exp Ther. 305:97-105. 
  7. Martin, F.L., Chen, H.H., Cataliotti, A., Burnett, J.C. (2008).Targeting the kidney in acute decompensated heart failure: conventional diuretics and renal-acting vasodilators. Rev Cardiovasc Med. 9:39-45.
  8. Oerlemans, M.I., Liu, J., Arslan, F., den Ouden, K., van Middelaar, B.J., Doevendans, P.A., Sluijter, J.P. (2012). Inhibition of RIP1-    dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo. Basic Res Cardiol. 107:270.
  9. Oztosun, M., Akgul, E.O., Cakir, E., Cayci, T., Uysal, B., Ogur, R., Ozcan, A., Ozgurtas, T., Guven, A., Korkmaz, A. (2012). The effects of medical ozone therapy on renal ischemia/reperfusion injury. Ren Fail. 34:921-925.
  10. Parlakpinar, H., Ozer, M.K., Cicek, E., Cigremis, Y., Vardi, N., Acet, A. (2006). Renal damage in rats induced by myocardial ischemia/    reperfusion: Role of nitric oxide. Int J Urol. 13:1327-1332.
  11. Peglow, S., Toledo, A.H., Anaya-Prado, R., Lopez-Neblina, F., Toledo-Pereyra, L.H. (2011). Allopurinol and xanthine oxidase inhibition in liver ischemia reperfusion. J Hepatobiliary Pancreat Sci. 18:137-146.
  12. Raedschelders, K., Ansley, D.M., Chen, D.D. (2012). The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion. Pharmacol Ther, 133:230-255.
  13. Ritz, E. (2006). Heart and kidney: fatal twins? Am J Med. 119:S31-39.
  14. Rodrigo, R., Gonzalez, J., Paoletto, F. (2011). The role of oxidative stress in the pathophysiology of hypertension. Hypertens Res. 34:431-440.
  15. Ronco, C., Kaushik, M., Valle, R., Aspromonte, N., Peacock, W.F. (2012). Diagnosis and management of fluid overload in heart failure and cardio-renal syndrome: the “5B” approach. Semin Nephrol, 32:129-141.
  16. Ronco, C., McCullough, P., Anker, S.D., Anand, I., Aspromonte, N., Bagshaw, S.M., Bellomo, R., Berl, T., Bobek, I., Cruz, D.N., Daliento, L., Davenport, A., Haapio, M., Hillege, H., House, A.A., Katz, N., Maisel, A., G., Zamperetti, N., Ponikowski, P., Acute Dialysis Quality Initiative (ADQI) consensus group. (2010). Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative. Eur Heart J. 31:703-711. 
  17. Rupender, K., Ashok K. S., Reema R., Ibandalin M., Rai, P.K. (2019). Medicinal qualities of mustard oil and its role in human health against chronic diseases: A Review.Asian Journal of Dairy and Food Research. DOI:10.18805/ajdfr.DR-1443. 
  18. Selimoglu, O., Basaran, M., Ozcan, H., Kafali, E., Ugurlucan, M., Ozcelebi, C., Ogus, N.T. (2007). A practical and effective approach for the prevention of ischemia-reperfusion injury after acute myocardial infarction: pressure-regulated tepid blood reperfusion. Heart Surg Forum. 10:E309-314.
  19. Shah, B.N. and Greaves, K. (2010). The cardiorenal syndrome: a review. Int J Nephrol. 920195. 
  20. Stallwood, M.I., Grayson, A.D., Mills, K. and Scawn, N.D. (2004). Acute renal failure in coronary artery bypass surgery: independent effect of cardiopulmonary bypass. Ann Thorac Surg. 77:968-972.
  21. Thomas, B.A., Logar, C.M. anderson, A.E. (2012). Renal replacement therapy in congestive heart failure requiring left ventricular assist device augmentation. Perit Dial Int. 32:386-392.
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Indian Journal of Animal Research
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    Research Article

    volume 54 issue 12 (december 2020) : 1486-1489,   Doi: 10.18805/ijar.B-1150

    Renal Damage Induced by Myocardial Ischemia Reperfusion in Mouse: Role of Oxidative Stress

    X
    Xue Tong
    H
    Hong Zhao
    X
    Xiaomei Lu
    1Department of Functional Experiment No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning Province, P.R. China.
    Cite article:- Tong Xue, Zhao Hong, Lu Xiaomei (2019). Renal Damage Induced by Myocardial Ischemia Reperfusion in Mouse: Role of Oxidative Stress. Indian Journal of Animal Research. 54(12): 1486-1489. doi: 10.18805/ijar.B-1150.

    ABSTRACT

    The aim of this study was to investigate whether oxidative stress has a role in myocardial ischemia reperfusion induced renal damage. The 30 male C57 mice were divided into control group, myocardial ischemia reperfusion (MIR) group and MnTBAP treatment group. In MIR group, the left coronary artery was occluded for 45minutes and reperfusion for 4 weeks. The same procedure was used for the MnTBAP group, with the additional step of MnTBAP (10mg/kg) administered intraperitoneally for 28 days. Before surgery and 4 weeks later, transthoracic echocardiography was performed and urine protein and albumin were measured. At the end of the time, mice were sacrified and kidneys collected for ROS and fibrosis analysis. The plasma was collected for BUN and SCR determination. It was observed that MIR decreased renal function and increased production of ROS, compelled with renal fibrosis. Administration of MnTBAP reduced production of ROS and renal fibrosis and increased renal function. These findings suggest that the MIR plays a causal role in causing renal injury and the MnTBAP exerts renal-protective effects, probably by its antioxidant activities.

    REFERENCES

    1. Coresh, J., Astor, B.C., Greene, T., Eknoyan, G., Levey, A.S. (2003). Prevalence of chronic kidney disease and decreased kidney function in the adult US population: Third National Health and Nutrition Examination Survey. Am J Kidney Dis. 41:1-12.
    2. Guazzi, M. V.A., Labate, V., Arena, R. (2012). Treatment for pulmonary hypertension of left Heart disease. Curr Treat Options Cardiovasc Med. 14:319-327.
    3. Hamza, R.G., Shahat, A.N.E., Al-seeni, M.N. (2019). Studying the antioxidant role of mushroom against hazards of gamma radiation exposure in male rats.Indian Journal of Animal Research. DOI:10.18805/ijar.B-387.
    4. Ilhan, B.D., Ibrahim, K., Omer, E.Y., Metin, I., Serkan, K., Ferda, K.C., Resit, C., Aziz, I.C., Murat, C., Durdu, A. (2019). The effect of nizatidine on ovarian ischaemia/reperfusion injury in rats. Indian Journal of Animal Research. DOI:10.18805/ijar.B-934
    5. Indhu, M.S., Sesh, P.S.L., Loganathasamy, K., Jeyaraja, K., Padmanath, K., Pandiyan, V. (2019). Analysis of certain blood biochemical parameters in relation to oxidative stress in chronic mitral valve insufficiency of dogs with heart failure. Indian Journal of Animal Research. DOI:10.18805/ijar.B-3632.
    6. Maki, T., Nasa, Y., Tanonaka, K., Takahashi, M., Takeo, S. (2003). Beneficial effects of sampatrilat, a novel vasopeptidase inhibitor, on cardiac remodeling and function of rats with chronic heart failure following left coronary artery ligation. J Pharmacol Exp Ther. 305:97-105. 
    7. Martin, F.L., Chen, H.H., Cataliotti, A., Burnett, J.C. (2008).Targeting the kidney in acute decompensated heart failure: conventional diuretics and renal-acting vasodilators. Rev Cardiovasc Med. 9:39-45.
    8. Oerlemans, M.I., Liu, J., Arslan, F., den Ouden, K., van Middelaar, B.J., Doevendans, P.A., Sluijter, J.P. (2012). Inhibition of RIP1-    dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo. Basic Res Cardiol. 107:270.
    9. Oztosun, M., Akgul, E.O., Cakir, E., Cayci, T., Uysal, B., Ogur, R., Ozcan, A., Ozgurtas, T., Guven, A., Korkmaz, A. (2012). The effects of medical ozone therapy on renal ischemia/reperfusion injury. Ren Fail. 34:921-925.
    10. Parlakpinar, H., Ozer, M.K., Cicek, E., Cigremis, Y., Vardi, N., Acet, A. (2006). Renal damage in rats induced by myocardial ischemia/    reperfusion: Role of nitric oxide. Int J Urol. 13:1327-1332.
    11. Peglow, S., Toledo, A.H., Anaya-Prado, R., Lopez-Neblina, F., Toledo-Pereyra, L.H. (2011). Allopurinol and xanthine oxidase inhibition in liver ischemia reperfusion. J Hepatobiliary Pancreat Sci. 18:137-146.
    12. Raedschelders, K., Ansley, D.M., Chen, D.D. (2012). The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion. Pharmacol Ther, 133:230-255.
    13. Ritz, E. (2006). Heart and kidney: fatal twins? Am J Med. 119:S31-39.
    14. Rodrigo, R., Gonzalez, J., Paoletto, F. (2011). The role of oxidative stress in the pathophysiology of hypertension. Hypertens Res. 34:431-440.
    15. Ronco, C., Kaushik, M., Valle, R., Aspromonte, N., Peacock, W.F. (2012). Diagnosis and management of fluid overload in heart failure and cardio-renal syndrome: the “5B” approach. Semin Nephrol, 32:129-141.
    16. Ronco, C., McCullough, P., Anker, S.D., Anand, I., Aspromonte, N., Bagshaw, S.M., Bellomo, R., Berl, T., Bobek, I., Cruz, D.N., Daliento, L., Davenport, A., Haapio, M., Hillege, H., House, A.A., Katz, N., Maisel, A., G., Zamperetti, N., Ponikowski, P., Acute Dialysis Quality Initiative (ADQI) consensus group. (2010). Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative. Eur Heart J. 31:703-711. 
    17. Rupender, K., Ashok K. S., Reema R., Ibandalin M., Rai, P.K. (2019). Medicinal qualities of mustard oil and its role in human health against chronic diseases: A Review.Asian Journal of Dairy and Food Research. DOI:10.18805/ajdfr.DR-1443. 
    18. Selimoglu, O., Basaran, M., Ozcan, H., Kafali, E., Ugurlucan, M., Ozcelebi, C., Ogus, N.T. (2007). A practical and effective approach for the prevention of ischemia-reperfusion injury after acute myocardial infarction: pressure-regulated tepid blood reperfusion. Heart Surg Forum. 10:E309-314.
    19. Shah, B.N. and Greaves, K. (2010). The cardiorenal syndrome: a review. Int J Nephrol. 920195. 
    20. Stallwood, M.I., Grayson, A.D., Mills, K. and Scawn, N.D. (2004). Acute renal failure in coronary artery bypass surgery: independent effect of cardiopulmonary bypass. Ann Thorac Surg. 77:968-972.
    21. Thomas, B.A., Logar, C.M. anderson, A.E. (2012). Renal replacement therapy in congestive heart failure requiring left ventricular assist device augmentation. Perit Dial Int. 32:386-392.
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