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Current IssueEditorial BoardOnline First Articles
Indian Journal of
Animal Research
Print ISSN: 0367-6722
Online ISSN: 0976-0555
NASS Rating
6.40
SJR
0.233
CiteScore
0.606

Chief Editor:
M. R. Saseendranath
Kerala Veterinary and Animal Science University, Mannuthy, Thrissur, INDIA
Frequency:Monthly
Indexing:
Science Citation Index Expanded, BIOSIS Preview, ISI Citation Index, Biological Abstracts, Scopus, ...

Indian Journal of Animal Research, volume 45 issue 2 (june 2011) : 130 - 134

SUB CHRONIC TOXICITY STUDY OF RHIZOPUS ORYZAE CULTURE FILTRATE FROM GROUND NUT HAY IN RATS

Vinay Tikare, N.B. Shridhar*, H.D. Narayanaswamy, Shrikrishna Isloor, K. Jayakumar.
1Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal and Fisheries Sciences University, Veterinary College, Hebbal, Bangalore - 560 024, India

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Cite article:- Tikare Vinay, Shridhar* N.B., Narayanaswamy H.D., Isloor Shrikrishna, Jayakumar. K. (2025). SUB CHRONIC TOXICITY STUDY OF RHIZOPUS ORYZAE CULTURE FILTRATE FROM GROUND NUT HAY IN RATS . Indian Journal of Animal Research. 45(2): 130 - 134. doi: .

ABSTRACT

Sub chronic toxicity study of culture filtrate of Rhizopus oryzae isolated from the fungal contaminated ground nut hay was conducted in rats. The fungi was isolated from the contaminated groundnut hay, which caused mycotoxicosis in cross bred cattle, which  exhibited the clinical signs of  colic, tenesmus, ruminal atony,anorexia, bleeding from nostrils, rectum and fly bite site. The rats were gavaged with culture filtrate at the dose level of 0.5, 1 and 2 ml daily for 90 days.  Clinical signs observed were diarrhea, weakness, slight arching of back and swollen forehead. Loss of balance in the legs region seen. There was a significant increase    (P

REFERENCES

  1. Fodor, J., Meyer, K., Riedlberger, M., Bauer, J. and Posa, R. (2006). The distribution and elimination of fumonisins after oral administration of Fusarium verticillioides fungal culture. Magy. Allatorv. Lapja., 128: 334-342.
  2. Junsuk, P., Kyungrim, L., Jincheol, K., Sunhee, L., Jeongah, S. and Yinwon, L. (1999). A hemorrhagic factor (apicidin) produced by toxic Fusarium isolates from soybean seeds. Appl. Environ. Microbiol., 4:126-130.
  3. Kellerman, T.S., Marasas, W.F.O., Thiel, P.G., Gelderblom, W.C.A., Cawood, M.J. and Coetzer, A.W. (1990). Leukoencephalomalacia in two horses induced by oral dosing of fumonisin B1.Onderstepoort J. Vet. Res., 57: 269-275.
  4. Luna, L.G. (1968). Manual of Histopathological Staining Methods of The Armed Forces Institute Of Pathology. 3rd Edn. McGraw Hill Book Co, New York. p. 25-78.
  5. Pier A C. (1992). Major biological consequences of aflatoxicosis in animal production. J. Anim. Sci., 70: 3964-3970.
  6. Petrie, L., Robb, J. and Stewart, A.F. (1977). The identification of T-2 toxin and its association with a hemorrhagic syndrome in cattle. Vet. Rec., 101: 326-326.
  7. Sharma, R.B., Kumar, A. and Roy, A.N. (1983). Nature of hepatic damage induced by culture filtrates of seed-borne fungi in the laboratory rat. Toxicol. Lett., 19: 1-2.
  8. Voss, K.A., Chamberlain, W.J., Bacon, C.W., Herbert, R.A., Walters, D.B. and Norred, W.P. (1995). Sub chronic feeding study of the mycotoxin fumonisin B1 in B6C3F1 mice and Fischer 344 rats. Fundam. Appl. Toxicol., 24: 102 -110.
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