SUB CHRONIC TOXICITY STUDY OF RHIZOPUS ORYZAE CULTURE FILTRATE FROM GROUND NUT HAY IN RATS

Article Id: ARCC793 | Page : 130 - 134
Citation :- SUB CHRONIC TOXICITY STUDY OF RHIZOPUS ORYZAE CULTURE FILTRATE FROM GROUND NUT HAY IN RATS .Indian Journal Of Animal Research.2011.(45):130 - 134
Vinay Tikare, N.B. Shridhar*, H.D. Narayanaswamy, Shrikrishna Isloor and K. Jayakumar. sridhar_vet@rediffmail.com
Address : Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal and Fisheries Sciences University, Veterinary College, Hebbal, Bangalore - 560 024, India

Abstract

Sub chronic toxicity study of culture filtrate of Rhizopus oryzae isolated from the fungal contaminated ground nut hay was conducted in rats. The fungi was isolated from the contaminated groundnut hay, which caused mycotoxicosis in cross bred cattle, which  exhibited the clinical signs of  colic, tenesmus, ruminal atony,anorexia, bleeding from nostrils, rectum and fly bite site. The rats were gavaged with culture filtrate at the dose level of 0.5, 1 and 2 ml daily for 90 days.  Clinical signs observed were diarrhea, weakness, slight arching of back and swollen forehead. Loss of balance in the legs region seen. There was a significant increase    (P

Keywords

Rhizopus oryzae Culture filtrate Groundnut hay Sub chronic toxicity Rat.

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