PHARMACOKINETICS, DISTRIBUTIONAND DOSAGE REGIMEN OF CEFUROXIME IN LACfATING GOATS AFTER INTRAVENOUS ADMINISTRATION·

Shahid Prawez1; C. Jayachandran; A. Quasim; M.K. Singh

Indian Journal of Animal Research

Chief EditorM. R. Saseendranath
Print ISSN 0367-6722
Online ISSN 0976-0555
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Indian Journal of Animal Research, volume 38 issue 2 (july to december 2004) : 107 - 111

PHARMACOKINETICS, DISTRIBUTIONAND DOSAGE REGIMEN OF CEFUROXIME IN LACfATING GOATS AFTER INTRAVENOUS ADMINISTRATION·

Shahid Prawez1, C. Jayachandran, A. Quasim, M.K. Singh

Affiliations

¹Bihar Veterinary College, Patna - 800 014, India

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Cite article:- Prawez1 Shahid, Jayachandran C., Quasim A., Singh M.K. (2025). PHARMACOKINETICS, DISTRIBUTIONAND DOSAGE REGIMEN OF CEFUROXIME IN LACfATING GOATS AFTER INTRAVENOUS ADMINISTRATION·. Indian Journal of Animal Research. 38(2): 107 - 111. doi: .

ABSTRACT

Pharmacokinetic study of cefuroxime, a second generation cephalosporin was conducted in six lactating goats after i.v. administration (20 mg/kg). The therapeutic concentration (≥1.0 μg/ml) was maintained from 2.5 min to 1 h, 30 to 45 min and 2.5 min to 12 h in plasma, milk and urine, respectively. Distribution half life (t½ α) of 0.58±0.09 h and elimination half life (t½ β) of 3.35±0.09 h were obtained for cefuroxime in goats. A high Vdarea of 5.88±0.48 L/kg denotes greater distribution of the drug in different body fluids and tissues. This fact is supported by higher approximate tissue to plasma concentration ratio (T ≈ P) ratio of 4.80±1.84 and also higher drug concentrations obtained in milk. Total body clearance (ClB) value of 20.23±1.39 ml/kg/min was obtained in goats in the present study. For treating mild to moderate systemic infections (Cp∞ min = 0.5 μg/ml), the required loading (D*) and maintenance (Do) doses calculated as 15 and 12 mg/kg at the dosage interval (γ) of 8 h while for treating severe systemic infections (Cp∞ min =1.0 μg/ml), D* and Do of 20 and 14 mg/kg at the dosage interval (γ), respectively are calculated following i.v. administration

KEYWORDS

REFERENCES

Arret, B. et al, (1971). J. Pkarma. Sci., 60: 1689-1694.
Bagget, J.D. (1977). Principles of Drug Disposition in Domestic Animals. The Basis of Veterinary Clinical Pharmacology.
I" edn. WB. Saunders Publishing Co., PhUadelphia.
Caprile, K.A. (1988). J. Vet. Pharmacal. Ther., 11: 1-32.
Foord, R.D. (1976). Antimicfob. Agents Chemother., 9: 741-747.
Gibaldi, M. and Perrier, D. (1982). Pharmacokinetics. Marcell Dekker Inc., New York.
Gold, B. and Rodriguez, W.S. (1983). Pharmacothet., 3: 82-100.
Notari, R.E. (1980). Bio·pharmaceutics and Clinical Pharmacokinetics. 3rd ed. Marcell Dekker Inc., New York.
Soback, S. et a/. (1989). J. Vet. Pharmacol. Ther., 12: 87-93.
Srivastava, A.K. and Chaudhary, RK (1999). ICAR short course on "Recent Approaches in Clinical Pharmacokinetics and Therapeutic Monitoring of Drugs in Farm Animals". Oct. 25 to Nov. 3. Division of Pharmacology and Toxicology, IVRI, Izatnagar, India.

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[
arret_1971] Arret, B. et al, (1971). J. Pkarma. Sci., 60: 1689-1694.

[2] Bagget, J.D. (1977). Principles of Drug Disposition in Domestic Animals. The Basis of Veterinary Clinical Pharmacology.

[3] I" edn. WB. Saunders Publishing Co., PhUadelphia.

[4] Caprile, K.A. (1988). J. Vet. Pharmacal. Ther., 11: 1-32.

[5] Foord, R.D. (1976). Antimicfob. Agents Chemother., 9: 741-747.

[6] Gibaldi, M. and Perrier, D. (1982). Pharmacokinetics. Marcell Dekker Inc., New York.

[7] Gold, B. and Rodriguez, W.S. (1983). Pharmacothet., 3: 82-100.

[8] Notari, R.E. (1980). Bio·pharmaceutics and Clinical Pharmacokinetics. 3rd ed. Marcell Dekker Inc., New York.

[9] Soback, S. et a/. (1989). J. Vet. Pharmacol. Ther., 12: 87-93.

[10] Srivastava, A.K. and Chaudhary, RK (1999). ICAR short course on "Recent Approaches in Clinical Pharmacokinetics and Therapeutic Monitoring of Drugs in Farm Animals". Oct. 25 to Nov. 3. Division of Pharmacology and Toxicology, IVRI, Izatnagar, India.

PHARMACOKINETICS, DISTRIBUTIONAND DOSAGE REGIMEN OF CEFUROXIME IN LACfATING GOATS AFTER INTRAVENOUS ADMINISTRATION·

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