volume 38 issue 2 (july to december 2004) : 107 - 111
PHARMACOKINETICS, DISTRIBUTIONAND DOSAGE REGIMEN OF CEFUROXIME IN LACfATING GOATS AFTER INTRAVENOUS ADMINISTRATION·
1Bihar Veterinary College, Patna - 800 014, India
ABSTRACT
Pharmacokinetic study of cefuroxime, a second generation cephalosporin was conducted in six lactating goats after i.v. administration (20 mg/kg). The therapeutic concentration (≥1.0 μg/ml) was maintained from 2.5 min to 1 h, 30 to 45 min and 2.5 min to 12 h in plasma, milk and urine, respectively. Distribution half life (t½ α) of 0.58±0.09 h and elimination half life (t½ β) of 3.35±0.09 h were obtained for cefuroxime in goats. A high Vdarea of 5.88±0.48 L/kg denotes greater distribution of the drug in different body fluids and tissues. This fact is supported by higher approximate tissue to plasma concentration ratio (T ≈ P) ratio of 4.80±1.84 and also higher drug concentrations obtained in milk. Total body clearance (ClB) value of 20.23±1.39 ml/kg/min was obtained in goats in the present study. For treating mild to moderate systemic infections (Cp∞ min = 0.5 μg/ml), the required loading (D*) and maintenance (Do) doses calculated as 15 and 12 mg/kg at the dosage interval (γ) of 8 h while for treating severe systemic infections (Cp∞ min =1.0 μg/ml), D* and Do of 20 and 14 mg/kg at the dosage interval (γ), respectively are calculated following i.v. administration
KEYWORDS
REFERENCES
- Arret, B. et al, (1971). J. Pkarma. Sci., 60: 1689-1694.
- Bagget, J.D. (1977). Principles of Drug Disposition in Domestic Animals. The Basis of Veterinary Clinical Pharmacology.
- I" edn. WB. Saunders Publishing Co., PhUadelphia.
- Caprile, K.A. (1988). J. Vet. Pharmacal. Ther., 11: 1-32.
- Foord, R.D. (1976). Antimicfob. Agents Chemother., 9: 741-747.
- Gibaldi, M. and Perrier, D. (1982). Pharmacokinetics. Marcell Dekker Inc., New York.
- Gold, B. and Rodriguez, W.S. (1983). Pharmacothet., 3: 82-100.
- Notari, R.E. (1980). Bio·pharmaceutics and Clinical Pharmacokinetics. 3rd ed. Marcell Dekker Inc., New York.
- Soback, S. et a/. (1989). J. Vet. Pharmacol. Ther., 12: 87-93.
- Srivastava, A.K. and Chaudhary, RK (1999). ICAR short course on "Recent Approaches in Clinical Pharmacokinetics and Therapeutic Monitoring of Drugs in Farm Animals". Oct. 25 to Nov. 3. Division of Pharmacology and Toxicology, IVRI, Izatnagar, India.
Disclaimer :
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Copyright :
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Published In
Indian Journal of Animal Research
Article Metrics
0
Views
Citations
Reviewed By
In this Article
APC
APC cover the cost of turning a manuscript into a published manuscript through peer-review process, editorial work as well as the cost of hosting, distributing, indexing and promoting the manuscript.
Publish With US
Submit your manuscript through user friendly platform and acquire the maximum impact for your research by publishing with ARCC Journals.
Become a Reviewer/Member
Join our esteemed reviewers panel and become an editorial board member with international experts in the domain of numerous specializations.
Open Access
Filling the gap between research and communication ARCC provide Open Access of all journals which empower research community in all the ways which is accessible to all.
Products and Services
We provide prime quality of services to assist you select right product of your requirement.
Support and Policies
Finest policies are designed to ensure world class support to our authors, members and readers. Our efficient team provides best possible support for you.
