Banner
Current IssueEditorial BoardOnline First ArticlesArchive
Current IssueEditorial BoardOnline First ArticlesArchive

volume 40 issue 2 (june 2006) : 131 - 134

EFFECT OF ESCHERICHIA COLI ENDOTOXIN INDUCED FEVER ON THE KINETICS AND DOSAGE REGIMEN OF CEFUROXIME IN GOATS

S
Shahid Prawez
R
Rajinder Raina
1Division of Pharmacology and Toxicology, F. V. Sc. and A.H., SKUAST-J, R.S. Pura, Jammu - 181 102, India

  • Submitted|

  • First Online |

  • doi

Cite article:- Prawez Shahid, Raina Rajinder (2025). EFFECT OF ESCHERICHIA COLI ENDOTOXIN INDUCED FEVER ON THE KINETICS AND DOSAGE REGIMEN OF CEFUROXIME IN GOATS. Indian Journal of Animal Research. 40(2): 131 - 134. doi: .

ABSTRACT

The pharmacokinetics and dosage regimen of cefuroxime were determined in normal and
febrile goats following its single intravenous administration @ 20 mg/kg. Fever was induced by
a single intravenous injection of Escherichia coli endotoxin @ 1.0 μg kg-1. The distribution half
life (t½ α) and total body clearance (ClB) were found significantly lower in febrile goats (t½ α =
0.23 ± 0.03 hr and ClB = 11.23 ± 0.57ml kg-1 min-1) as compared to healthy goats (t½ α =
0.58 ± 0.09 hr and ClB = 20.23 ± 1.39 ml kg-1 min-1). The elimination half life (t½ β) and
apparent volume of distribution (Vdarea) were found significantly higher in febrile goats (t½ β =
8.07 ± 0.34 hr and Vdarea = 7.78 ± 0.24 L kg-1) compared to healthy goats (t½ β = 3.35 ± 0.09
hr and Vdarea = 5.88 ± 0.48 L kg-1). An intravenous dosage regimen suitable for maintaining the
minimum therapeutic plasma concentration of 1.0 μg ml-1 in febrile animal would be @ 22 mg/
kg body weight as loading dose (D*) and @ 15 mg/kg as maintenance dose(D0) repeated at 12
hourly dosage intervals

KEYWORDS

    REFERENCES

    1. Arret, B. et al. (1971). J. Pharm. Sci., 60: 1689 -1694.
    2. Caprile, K.A. (1988). J. Vet. Pharmacol. Ther., 11: 1-32.
    3. Chaudhary, R.K. et al. (1999). Vet. Res. Comm., 23: 361-368.
    4. Chaudhary, R.K. et al. (2001). Indian J. Pharmacol., 33: 425-430.
    5. Gibaldi, M. and Perrier, D. (1982). Pharmacokinetics. Marcel Dekker Inc., New York, pp. 433-444.
    6. Mandell, G.L. and Sande, M.A. (1991). Goodman and Oilman’s The Pharmacological Basis of Therapeutics.
    7. Singapore, Maxwell Macmillan, pp. 1065-97.
    8. Smith, B.R. and Lefrock, J.L. (1983). Thera. Drug Monit., 5: 149-160.
    9. Snedecor, W.G. and Cochran (1967). Statistical Method. 6th edn., Oxford and IBH publishing Co., New Delhi.
    Published In
    Indian Journal of Animal Research
    Article Metrics
    Metrics Icon
    0
    Views
    0
    Citations
    Reviewed By
    Share Article
    Download Article
    In this Article
      Contact us
      Follow us

      volume 40 issue 2 (june 2006) : 131 - 134

      EFFECT OF ESCHERICHIA COLI ENDOTOXIN INDUCED FEVER ON THE KINETICS AND DOSAGE REGIMEN OF CEFUROXIME IN GOATS

      S
      Shahid Prawez
      R
      Rajinder Raina
      1Division of Pharmacology and Toxicology, F. V. Sc. and A.H., SKUAST-J, R.S. Pura, Jammu - 181 102, India

      • Submitted|

      • First Online |

      • doi

      Cite article:- Prawez Shahid, Raina Rajinder (2025). EFFECT OF ESCHERICHIA COLI ENDOTOXIN INDUCED FEVER ON THE KINETICS AND DOSAGE REGIMEN OF CEFUROXIME IN GOATS. Indian Journal of Animal Research. 40(2): 131 - 134. doi: .

      ABSTRACT

      The pharmacokinetics and dosage regimen of cefuroxime were determined in normal and
      febrile goats following its single intravenous administration @ 20 mg/kg. Fever was induced by
      a single intravenous injection of Escherichia coli endotoxin @ 1.0 μg kg-1. The distribution half
      life (t½ α) and total body clearance (ClB) were found significantly lower in febrile goats (t½ α =
      0.23 ± 0.03 hr and ClB = 11.23 ± 0.57ml kg-1 min-1) as compared to healthy goats (t½ α =
      0.58 ± 0.09 hr and ClB = 20.23 ± 1.39 ml kg-1 min-1). The elimination half life (t½ β) and
      apparent volume of distribution (Vdarea) were found significantly higher in febrile goats (t½ β =
      8.07 ± 0.34 hr and Vdarea = 7.78 ± 0.24 L kg-1) compared to healthy goats (t½ β = 3.35 ± 0.09
      hr and Vdarea = 5.88 ± 0.48 L kg-1). An intravenous dosage regimen suitable for maintaining the
      minimum therapeutic plasma concentration of 1.0 μg ml-1 in febrile animal would be @ 22 mg/
      kg body weight as loading dose (D*) and @ 15 mg/kg as maintenance dose(D0) repeated at 12
      hourly dosage intervals

      KEYWORDS

        REFERENCES

        1. Arret, B. et al. (1971). J. Pharm. Sci., 60: 1689 -1694.
        2. Caprile, K.A. (1988). J. Vet. Pharmacol. Ther., 11: 1-32.
        3. Chaudhary, R.K. et al. (1999). Vet. Res. Comm., 23: 361-368.
        4. Chaudhary, R.K. et al. (2001). Indian J. Pharmacol., 33: 425-430.
        5. Gibaldi, M. and Perrier, D. (1982). Pharmacokinetics. Marcel Dekker Inc., New York, pp. 433-444.
        6. Mandell, G.L. and Sande, M.A. (1991). Goodman and Oilman’s The Pharmacological Basis of Therapeutics.
        7. Singapore, Maxwell Macmillan, pp. 1065-97.
        8. Smith, B.R. and Lefrock, J.L. (1983). Thera. Drug Monit., 5: 149-160.
        9. Snedecor, W.G. and Cochran (1967). Statistical Method. 6th edn., Oxford and IBH publishing Co., New Delhi.
        In this Article
          Contact us
          Follow us
          Published In
          Indian Journal of Animal Research

          Editorial Board

          View all (0)