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M. R. Saseendranath

Kerala Veterinary and Animal Science University, Mannuthy, Thrissur, INDIA

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EFFECT OF ESCHERICHIA COLI ENDOTOXIN INDUCED FEVER ON THE KINETICS AND DOSAGE REGIMEN OF CEFUROXIME IN GOATS

Shahid Prawez, Rajinder Raina

Affiliations

¹Division of Pharmacology and Toxicology, F. V. Sc. and A.H., SKUAST-J, R.S. Pura, Jammu - 181 102, India

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Cite article:- Prawez Shahid, Raina Rajinder (2025). EFFECT OF ESCHERICHIA COLI ENDOTOXIN INDUCED FEVER ON THE KINETICS AND DOSAGE REGIMEN OF CEFUROXIME IN GOATS. Indian Journal of Animal Research. 40(2): 131 - 134. doi: .

ABSTRACT

The pharmacokinetics and dosage regimen of cefuroxime were determined in normal and
febrile goats following its single intravenous administration @ 20 mg/kg. Fever was induced by
a single intravenous injection of Escherichia coli endotoxin @ 1.0 μg kg-1. The distribution half
life (t½ α) and total body clearance (ClB) were found significantly lower in febrile goats (t½ α =
0.23 ± 0.03 hr and ClB = 11.23 ± 0.57ml kg-1 min-1) as compared to healthy goats (t½ α =
0.58 ± 0.09 hr and ClB = 20.23 ± 1.39 ml kg-1 min-1). The elimination half life (t½ β) and
apparent volume of distribution (Vdarea) were found significantly higher in febrile goats (t½ β =
8.07 ± 0.34 hr and Vdarea = 7.78 ± 0.24 L kg-1) compared to healthy goats (t½ β = 3.35 ± 0.09
hr and Vdarea = 5.88 ± 0.48 L kg-1). An intravenous dosage regimen suitable for maintaining the
minimum therapeutic plasma concentration of 1.0 μg ml-1 in febrile animal would be @ 22 mg/
kg body weight as loading dose (D*) and @ 15 mg/kg as maintenance dose(D0) repeated at 12
hourly dosage intervals

KEYWORDS

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