Indian Journal of Animal Research

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Indian Journal of Animal Research, volume 40 issue 2 (june 2006) : 131 - 134

EFFECT OF ESCHERICHIA COLI ENDOTOXIN INDUCED FEVER ON THE KINETICS AND DOSAGE REGIMEN OF CEFUROXIME IN GOATS

Shahid Prawez, Rajinder Raina
1Division of Pharmacology and Toxicology, F. V. Sc. and A.H., SKUAST-J, R.S. Pura, Jammu - 181 102, India

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Cite article:- Prawez Shahid, Raina Rajinder (2024). EFFECT OF ESCHERICHIA COLI ENDOTOXIN INDUCED FEVER ON THE KINETICS AND DOSAGE REGIMEN OF CEFUROXIME IN GOATS. Indian Journal of Animal Research. 40(2): 131 - 134. doi: .

ABSTRACT

The pharmacokinetics and dosage regimen of cefuroxime were determined in normal and
febrile goats following its single intravenous administration @ 20 mg/kg. Fever was induced by
a single intravenous injection of Escherichia coli endotoxin @ 1.0 μg kg-1. The distribution half
life (t½ α) and total body clearance (ClB) were found significantly lower in febrile goats (t½ α =
0.23 ± 0.03 hr and ClB = 11.23 ± 0.57ml kg-1 min-1) as compared to healthy goats (t½ α =
0.58 ± 0.09 hr and ClB = 20.23 ± 1.39 ml kg-1 min-1). The elimination half life (t½ β) and
apparent volume of distribution (Vdarea) were found significantly higher in febrile goats (t½ β =
8.07 ± 0.34 hr and Vdarea = 7.78 ± 0.24 L kg-1) compared to healthy goats (t½ β = 3.35 ± 0.09
hr and Vdarea = 5.88 ± 0.48 L kg-1). An intravenous dosage regimen suitable for maintaining the
minimum therapeutic plasma concentration of 1.0 μg ml-1 in febrile animal would be @ 22 mg/
kg body weight as loading dose (D*) and @ 15 mg/kg as maintenance dose(D0) repeated at 12
hourly dosage intervals

KEYWORDS

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