EFFECT OF ESCHERICHIA COLI ENDOTOXIN INDUCED FEVER ON THE KINETICS AND DOSAGE REGIMEN OF CEFUROXIME IN GOATS

Article Id: ARCC3273 | Page : 131 - 134
Citation :- EFFECT OF ESCHERICHIA COLI ENDOTOXIN INDUCED FEVER ON THE KINETICS AND DOSAGE REGIMEN OF CEFUROXIME IN GOATS.Indian Journal Of Animal Research.2006.(40):131 - 134
Shahid Prawez and Rajinder Raina
Address : Division of Pharmacology and Toxicology, F. V. Sc. and A.H., SKUAST-J, R.S. Pura, Jammu - 181 102, India

Abstract

The pharmacokinetics and dosage regimen of cefuroxime were determined in normal and
febrile goats following its single intravenous administration @ 20 mg/kg. Fever was induced by
a single intravenous injection of Escherichia coli endotoxin @ 1.0 μg kg-1. The distribution half
life (t½ α) and total body clearance (ClB) were found significantly lower in febrile goats (t½ α =
0.23 ± 0.03 hr and ClB = 11.23 ± 0.57ml kg-1 min-1) as compared to healthy goats (t½ α =
0.58 ± 0.09 hr and ClB = 20.23 ± 1.39 ml kg-1 min-1). The elimination half life (t½ β) and
apparent volume of distribution (Vdarea) were found significantly higher in febrile goats (t½ β =
8.07 ± 0.34 hr and Vdarea = 7.78 ± 0.24 L kg-1) compared to healthy goats (t½ β = 3.35 ± 0.09
hr and Vdarea = 5.88 ± 0.48 L kg-1). An intravenous dosage regimen suitable for maintaining the
minimum therapeutic plasma concentration of 1.0 μg ml-1 in febrile animal would be @ 22 mg/
kg body weight as loading dose (D*) and @ 15 mg/kg as maintenance dose(D0) repeated at 12
hourly dosage intervals

Keywords

References

  1. Arret, B. et al. (1971). J. Pharm. Sci., 60: 1689 -1694.
  2. Caprile, K.A. (1988). J. Vet. Pharmacol. Ther., 11: 1-32.
  3. Chaudhary, R.K. et al. (1999). Vet. Res. Comm., 23: 361-368.
  4. Chaudhary, R.K. et al. (2001). Indian J. Pharmacol., 33: 425-430.
  5. Gibaldi, M. and Perrier, D. (1982). Pharmacokinetics. Marcel Dekker Inc., New York, pp. 433-444.
  6. Mandell, G.L. and Sande, M.A. (1991). Goodman and Oilman’s The Pharmacological Basis of Therapeutics.
  7. Singapore, Maxwell Macmillan, pp. 1065-97.
  8. Smith, B.R. and Lefrock, J.L. (1983). Thera. Drug Monit., 5: 149-160.
  9. Snedecor, W.G. and Cochran (1967). Statistical Method. 6th edn., Oxford and IBH publishing Co., New Delhi.

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