Indian Journal of Animal Research

  • Chief EditorK.M.L. Pathak

  • Print ISSN 0367-6722

  • Online ISSN 0976-0555

  • NAAS Rating 6.50

  • SJR 0.263

  • Impact Factor 0.4 (2024)

Frequency :
Monthly (January, February, March, April, May, June, July, August, September, October, November and December)
Indexing Services :
Science Citation Index Expanded, BIOSIS Preview, ISI Citation Index, Biological Abstracts, Scopus, AGRICOLA, Google Scholar, CrossRef, CAB Abstracting Journals, Chemical Abstracts, Indian Science Abstracts, EBSCO Indexing Services, Index Copernicus
Submit

Indian Journal of Animal Research, volume 41 issue 2 (june 2007) : 138 - 140

SOME PHARMACODYNAMIC EFFECTS OF PHENTHOATE

J.S. Punia, S.K. Jain
1Department of Veterinary Pharmacology and Toxicoloogy, CCS Haryana Agricultural University, Hisar - 125 004, India

  • Submitted|

  • First Online |

  • doi

Cite article:- Punia J.S., Jain S.K. (2024). SOME PHARMACODYNAMIC EFFECTS OF PHENTHOATE. Indian Journal of Animal Research. 41(2): 138 - 140. doi: .

ABSTRACT

Phenthoate (O, O-dimethyl S-alpha ethoxy carbonylbenzyl phosphorodithioate) was studied
for its pharmacodynamic effects on blood pressure in dog, isolated frog heart, skeletal muscle
(frog rectus abdominis) and smooth muscle (guinea pig ileum). Phenthoate did not produce
consistent effect on blood pressure of dog. No effect on resting tone of skeletal and smooth
muscle preparations was observed. Phenthoate neither inhibited nor potentiated the acetylcholineinduced contractions of skeletal muscles. However, it blocked non-specifically the acetylcholine, histamine, 5-hydroxytryptamine and barium chloride-induced contractions of guinea pig ileum. Phenthoate produced negative inotropic and chronotropic effect on isolated frog heart which was blocked by atropine, indicating the cholinomimetic effect as a result of cholinesterase inhibition which is the characteristic feature of organophosphorous compounds.

KEYWORDS

    REFERENCES

    1. Burgen, A.S.V. et al. (1949). J. Pharmacol. Exp. Therap., 96: 396-409.
    2. Duke, H.H. (1955). The Physiology of Domestic Animals. Comstock Publishing Associates, Ithaka, New York, pp. 170-173.
    3. Krop, S. and Kunkel, A.M. (1954). Proc. Soc. Exp. Biol. Med., 86: 530-533.
    4. Malik, J.K. (1975). Ph.D.Thesis, Haryana Agricultural University, Hisar, Haryana,India.
    5. Punia, J.S. et al. (1987). Haryana Vet., 26: 17-21.
    6. Punia, J.S. et al. (1989a). Indian Vet. J., 66: 516-18.
    7. Punia, J.S. et al. (1989b). Indian Vet. Med. J., 33: 190-193.
    8. Punia, J.S. et al. (1995). Indian J. Anim. Res., 29: 112-116.
    9. Salero, P.R. and Coon, J.M. (1949). J. Pharmacol. Exp. Therap., 95: 240-255
    Reviewed By

    Download Article
    In this Article
      Contact us
      Follow us

      Editorial Board

      View all (0)