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Current IssueEditorial BoardOnline First ArticlesArchive

volume 43 issue 4 (december 2009) : 279-281

EFFICACY OF MUCOSAL ADJUVANTS ON INDUCTION OF SYSTEMIC IMMUNE RESPONSES TO NEWCASTLE DISEASE VACCINE STRAIN

S
Sunil Shebannavar1*
S
S.K. Das2
N
Nagappa Kabasanavar3
A
A.M. Kotresh4
1Division of Immunology, Indian Veterinary Research Institute, Izatnagar, Bareilly-243 122, India.

  • Submitted|

  • First Online |

  • doi

Cite article:- Shebannavar1* Sunil, Das2 S.K., Kabasanavar3 Nagappa, Kotresh4 A.M. (2025). EFFICACY OF MUCOSAL ADJUVANTS ON INDUCTION OF SYSTEMIC IMMUNE RESPONSES TO NEWCASTLE DISEASE VACCINE STRAIN. Indian Journal of Animal Research. 43(4): 279-281. doi: .

ABSTRACT

Intranasal immunization of broiler chicks with lentogenic ‘F’ strain of Newcastle disease
incorporating or lacking mucosal adjuvants viz., Cholera toxin B subunit (CTB), heat labile
enterotoxin of Escherichia coli (LT) and a lipoidal amine adjuvant, averidine (Avr) was carried
out. Haemagglutination inhibition (HI) tests and indirect ELISA were done to assess the antiviral
serum antibody levels up to 6 weeks post vaccination. Relatively higher levels of antiviral serum
antibodies were observed in birds vaccinated with CTB adjuvanted vaccine. The early peaking of
antibody levels was also observed in CTB adjuvanted group. Higher in-vitro proliferation of
peripheral blood lymphocytes to viral antigen was observed in LT adjuvanted vaccine group.
These results suggest differential adjuvanting ability of bacterial toxins when co-administered
with live attenuated Newcastle disease vaccines.

REFERENCES

  1. Allan, W.H. et al. (1978). F.A.O, Animal Prod. Ser. No. 10, F.A.O, Rome.
  2. Bounous, D.I. et al,(1992). Avian Dis., 36:1022-1027.
  3. Girard, F. et al, (1999). Vaccine, 17:1516-1524.
  4. Kamiya, N. et al, (2001). Vaccine, 19:3131-3136.
  5. Martin, M. et al, (2000). Infect.Immun., 68:281-287.
  6. Mayo, S. et al, (2005). APMIS. 113:284-7.
  7. Rehmani, D.F. and Spradbrow, P.B. (1995a). Vet. Microbiol., 46:43-46.
  8. Rehmani, D.F. and Spradbrow, P.B. (1995b). Vet. Microbiol., 46: 63-67.
  9. Reynolds, D.L. and Maraqa, A.D. (2000). Avian Dis., 44:138-144.
  10. Shebannavar, S.N. et al, (2007). Indian. J. Animal. Sci., 77:126-128.
  11. Takada, A. and Kida, H. (1996). Vet. Microbiol. 50:17-25.
  12. Wiliknson, J. et al, (2003). Poult Sci, 82:1565-1572
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    volume 43 issue 4 (december 2009) : 279-281

    EFFICACY OF MUCOSAL ADJUVANTS ON INDUCTION OF SYSTEMIC IMMUNE RESPONSES TO NEWCASTLE DISEASE VACCINE STRAIN

    S
    Sunil Shebannavar1*
    S
    S.K. Das2
    N
    Nagappa Kabasanavar3
    A
    A.M. Kotresh4
    1Division of Immunology, Indian Veterinary Research Institute, Izatnagar, Bareilly-243 122, India.

    • Submitted|

    • First Online |

    • doi

    Cite article:- Shebannavar1* Sunil, Das2 S.K., Kabasanavar3 Nagappa, Kotresh4 A.M. (2025). EFFICACY OF MUCOSAL ADJUVANTS ON INDUCTION OF SYSTEMIC IMMUNE RESPONSES TO NEWCASTLE DISEASE VACCINE STRAIN. Indian Journal of Animal Research. 43(4): 279-281. doi: .

    ABSTRACT

    Intranasal immunization of broiler chicks with lentogenic ‘F’ strain of Newcastle disease
    incorporating or lacking mucosal adjuvants viz., Cholera toxin B subunit (CTB), heat labile
    enterotoxin of Escherichia coli (LT) and a lipoidal amine adjuvant, averidine (Avr) was carried
    out. Haemagglutination inhibition (HI) tests and indirect ELISA were done to assess the antiviral
    serum antibody levels up to 6 weeks post vaccination. Relatively higher levels of antiviral serum
    antibodies were observed in birds vaccinated with CTB adjuvanted vaccine. The early peaking of
    antibody levels was also observed in CTB adjuvanted group. Higher in-vitro proliferation of
    peripheral blood lymphocytes to viral antigen was observed in LT adjuvanted vaccine group.
    These results suggest differential adjuvanting ability of bacterial toxins when co-administered
    with live attenuated Newcastle disease vaccines.

    REFERENCES

    1. Allan, W.H. et al. (1978). F.A.O, Animal Prod. Ser. No. 10, F.A.O, Rome.
    2. Bounous, D.I. et al,(1992). Avian Dis., 36:1022-1027.
    3. Girard, F. et al, (1999). Vaccine, 17:1516-1524.
    4. Kamiya, N. et al, (2001). Vaccine, 19:3131-3136.
    5. Martin, M. et al, (2000). Infect.Immun., 68:281-287.
    6. Mayo, S. et al, (2005). APMIS. 113:284-7.
    7. Rehmani, D.F. and Spradbrow, P.B. (1995a). Vet. Microbiol., 46:43-46.
    8. Rehmani, D.F. and Spradbrow, P.B. (1995b). Vet. Microbiol., 46: 63-67.
    9. Reynolds, D.L. and Maraqa, A.D. (2000). Avian Dis., 44:138-144.
    10. Shebannavar, S.N. et al, (2007). Indian. J. Animal. Sci., 77:126-128.
    11. Takada, A. and Kida, H. (1996). Vet. Microbiol. 50:17-25.
    12. Wiliknson, J. et al, (2003). Poult Sci, 82:1565-1572
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