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M. R. Saseendranath

Kerala Veterinary and Animal Science University, Mannuthy, Thrissur, INDIA

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EFFICACY OF MUCOSAL ADJUVANTS ON INDUCTION OF SYSTEMIC IMMUNE RESPONSES TO NEWCASTLE DISEASE VACCINE STRAIN

Sunil Shebannavar1*, S.K. Das2, Nagappa Kabasanavar3, A.M. Kotresh4

Affiliations

¹Division of Immunology, Indian Veterinary Research Institute, Izatnagar, Bareilly-243 122, India.

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Cite article:- Shebannavar1* Sunil, Das2 S.K., Kabasanavar3 Nagappa, Kotresh4 A.M. (2025). EFFICACY OF MUCOSAL ADJUVANTS ON INDUCTION OF SYSTEMIC IMMUNE RESPONSES TO NEWCASTLE DISEASE VACCINE STRAIN. Indian Journal of Animal Research. 43(4): 279-281. doi: .

ABSTRACT

Intranasal immunization of broiler chicks with lentogenic ‘F’ strain of Newcastle disease
incorporating or lacking mucosal adjuvants viz., Cholera toxin B subunit (CTB), heat labile
enterotoxin of Escherichia coli (LT) and a lipoidal amine adjuvant, averidine (Avr) was carried
out. Haemagglutination inhibition (HI) tests and indirect ELISA were done to assess the antiviral
serum antibody levels up to 6 weeks post vaccination. Relatively higher levels of antiviral serum
antibodies were observed in birds vaccinated with CTB adjuvanted vaccine. The early peaking of
antibody levels was also observed in CTB adjuvanted group. Higher in-vitro proliferation of
peripheral blood lymphocytes to viral antigen was observed in LT adjuvanted vaccine group.
These results suggest differential adjuvanting ability of bacterial toxins when co-administered
with live attenuated Newcastle disease vaccines.

KEYWORDS

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