volume 43 issue 4 (december 2009) : 235-240
ACUTE ORAL TOXICITY AND HISTOPATHOLOGICAL STUDIES OF CYPERMETHRIN IN RATS
1Division of Toxicology, Department of Zoology,
Sri Venkateswara University, Tirupati-517 502, India.
ABSTRACT
Cypermethrin is a synthetic pyrethroid insecticide used to control pests in domestic, industrial
and agricultural situations. This study was carried out to investigate the acute oral toxicity and
histopathological changes of cypermethrin in albino rats. According to Finney’s probit analysis
method, at 48 h LD50 value of cypermethrin in rats was found to be 205 mg/kg bw by gavage.
Behavioral changes in rats after oral administration of cypermethrin showed motor signs. On
exposure to sublethal doses (41 mg/kg bw) of cypermethrin as single dose, double dose and
multiple dose, mild to severe histological changes in duodenum, lungs and testis were observed
by hematoxylin and eosin staining.
and agricultural situations. This study was carried out to investigate the acute oral toxicity and
histopathological changes of cypermethrin in albino rats. According to Finney’s probit analysis
method, at 48 h LD50 value of cypermethrin in rats was found to be 205 mg/kg bw by gavage.
Behavioral changes in rats after oral administration of cypermethrin showed motor signs. On
exposure to sublethal doses (41 mg/kg bw) of cypermethrin as single dose, double dose and
multiple dose, mild to severe histological changes in duodenum, lungs and testis were observed
by hematoxylin and eosin staining.
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Indian Journal of Animal Research
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