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Current IssueEditorial BoardOnline First ArticlesArchive

volume 43 issue 4 (december 2009) : 235-240

ACUTE ORAL TOXICITY AND HISTOPATHOLOGICAL STUDIES OF CYPERMETHRIN IN RATS

A
A. Nagarjuna
P
P. Jacob Doss
1Division of Toxicology, Department of Zoology, Sri Venkateswara University, Tirupati-517 502, India.

  • Submitted|

  • First Online |

  • doi

Cite article:- Nagarjuna A., Doss Jacob P. (2025). ACUTE ORAL TOXICITY AND HISTOPATHOLOGICAL STUDIES OF CYPERMETHRIN IN RATS. Indian Journal of Animal Research. 43(4): 235-240. doi: .

ABSTRACT

Cypermethrin is a synthetic pyrethroid insecticide used to control pests in domestic, industrial
and agricultural situations. This study was carried out to investigate the acute oral toxicity and
histopathological changes of cypermethrin in albino rats. According to Finney’s probit analysis
method, at 48 h LD50 value of cypermethrin in rats was found to be 205 mg/kg bw by gavage.
Behavioral changes in rats after oral administration of cypermethrin showed motor signs. On
exposure to sublethal doses (41 mg/kg bw) of cypermethrin as single dose, double dose and
multiple dose, mild to severe histological changes in duodenum, lungs and testis were observed
by hematoxylin and eosin staining.

REFERENCES

  1. Coombs, A.D., et al., (1976). Toxicity Studies on the Insecticide WL 43467: Summary of results of preliminary experiments, Sittingbourne, Shell Research (TLGR. 0104.76).
  2. Drury, R.A.B. and Wallington, E.A. (1980). Carleton’s Histological Technique. 4th Ed, Oxford University Press, Oxford.
  3. FAO (1980) Plant Production and Protection Paper No. 20 (Suppl).
  4. FAO/WHO. (1979). Evaluations of Some Pesticide Residues in Food, Food and Agriculture Organization of the United Nations, Rome.
  5. Finney, D.J.. (1971). Probit Analysis, Third Edition, Cambridge University Press, London.
  6. Hall, B.E., et al., (1980). A Study to Determine the Bioaccumulation of 14C-Cypemethrin Radioactivity in the Rat Following Repeated Oral Administration, Report No. 2487-72/20, WHO.
  7. Manna, S., et al., (2005). Indian J. Pharmacol., 37(3):160-164.
  8. Ray, D.E. (1991). In: Handbook of Pesticide Toxicology (Hayes WJ. Jr., Laws ER, Jr. eds). Academic Press, San Diego, California, 12:585-636.
  9. Timbrell, A.J. (1991). In: Principles of Biochemical Toxicology, Taylor and Francis, London.
  10. United States, Environmental Protection Agency. (2002). US EPA Health Effects Test Guidelines: Acute Toxicity Background, US EPA, viewed on October 29.
  11. United States, Environmental Protection Agency. (1989). Office of Pesticides and Toxic substances. Office of Pesticide Programs, Pesticide fact sheet cypermethrin No. 199. Washington, D.C (Jan. 3).
  12. Velmurugan, B. et al., (2007). J. Environ. Sci. Health Part B, 42:157-163.
  13. WHO. (1989). Environmental Health Criteria. Cypermethrin (Vol. 82). Geneva: United Nations Environmental Programme, the International Labor Organization, and the World Health Organization
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    volume 43 issue 4 (december 2009) : 235-240

    ACUTE ORAL TOXICITY AND HISTOPATHOLOGICAL STUDIES OF CYPERMETHRIN IN RATS

    A
    A. Nagarjuna
    P
    P. Jacob Doss
    1Division of Toxicology, Department of Zoology, Sri Venkateswara University, Tirupati-517 502, India.

    • Submitted|

    • First Online |

    • doi

    Cite article:- Nagarjuna A., Doss Jacob P. (2025). ACUTE ORAL TOXICITY AND HISTOPATHOLOGICAL STUDIES OF CYPERMETHRIN IN RATS. Indian Journal of Animal Research. 43(4): 235-240. doi: .

    ABSTRACT

    Cypermethrin is a synthetic pyrethroid insecticide used to control pests in domestic, industrial
    and agricultural situations. This study was carried out to investigate the acute oral toxicity and
    histopathological changes of cypermethrin in albino rats. According to Finney’s probit analysis
    method, at 48 h LD50 value of cypermethrin in rats was found to be 205 mg/kg bw by gavage.
    Behavioral changes in rats after oral administration of cypermethrin showed motor signs. On
    exposure to sublethal doses (41 mg/kg bw) of cypermethrin as single dose, double dose and
    multiple dose, mild to severe histological changes in duodenum, lungs and testis were observed
    by hematoxylin and eosin staining.

    REFERENCES

    1. Coombs, A.D., et al., (1976). Toxicity Studies on the Insecticide WL 43467: Summary of results of preliminary experiments, Sittingbourne, Shell Research (TLGR. 0104.76).
    2. Drury, R.A.B. and Wallington, E.A. (1980). Carleton’s Histological Technique. 4th Ed, Oxford University Press, Oxford.
    3. FAO (1980) Plant Production and Protection Paper No. 20 (Suppl).
    4. FAO/WHO. (1979). Evaluations of Some Pesticide Residues in Food, Food and Agriculture Organization of the United Nations, Rome.
    5. Finney, D.J.. (1971). Probit Analysis, Third Edition, Cambridge University Press, London.
    6. Hall, B.E., et al., (1980). A Study to Determine the Bioaccumulation of 14C-Cypemethrin Radioactivity in the Rat Following Repeated Oral Administration, Report No. 2487-72/20, WHO.
    7. Manna, S., et al., (2005). Indian J. Pharmacol., 37(3):160-164.
    8. Ray, D.E. (1991). In: Handbook of Pesticide Toxicology (Hayes WJ. Jr., Laws ER, Jr. eds). Academic Press, San Diego, California, 12:585-636.
    9. Timbrell, A.J. (1991). In: Principles of Biochemical Toxicology, Taylor and Francis, London.
    10. United States, Environmental Protection Agency. (2002). US EPA Health Effects Test Guidelines: Acute Toxicity Background, US EPA, viewed on October 29.
    11. United States, Environmental Protection Agency. (1989). Office of Pesticides and Toxic substances. Office of Pesticide Programs, Pesticide fact sheet cypermethrin No. 199. Washington, D.C (Jan. 3).
    12. Velmurugan, B. et al., (2007). J. Environ. Sci. Health Part B, 42:157-163.
    13. WHO. (1989). Environmental Health Criteria. Cypermethrin (Vol. 82). Geneva: United Nations Environmental Programme, the International Labor Organization, and the World Health Organization
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