Chief EditorK.M.L. Pathak
Print ISSN 0367-6722
Online ISSN 0976-0555
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COMPARATIVE EFFICACY OF OCULONASAL AND INTRANASAL ROUTES OF VACCINATION IN INDUCTION OF IMMUNE RESPONSE AGAINST NEWCASTLE DISEASE VIRUS
vaccines or inactivated vaccines to induce protective immunity. In order to further characterize
the immune response elicited by live virus, we evaluated both cellular and humoral immune
response to Newcastle disease virus (NDV) consequent to vaccine application by oculonasal
and intranasal routes. Specific antiviral antibodies to NDV were detected as early as 7 days post
vaccination (PV). The peak antibody levels were achieved at 2 wk PV and 3 wk PV in chicken
vaccinated by oculonasal and intranasal route, respectively. The antibodies persisted upto 7 wk
PV albeit low levels. The NDV specific cell mediated immune response (CMI) as detected by
lymphocyte proliferation test was induced at 3 wks PV and that persisted upto 7 wk PV in
chicken vaccinated by both oculonasal and intranasal route. These results suggest that both
oculonasal and intranasal routes of vaccination induce comparable immune responses in chicken
vaccinated with lentogenic ND vaccine.
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