Indian Journal of Animal Research

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Indian Journal of Animal Research, volume 44 issue 3 (september 2010) : 193 - 196

HISTOPATHOLOGICAL CHANGES IN VITAL ORGANS OF HOUSE RATS GIVEN LETHAL DOSE OF CHOLECALCIFEROL (VITAMIN D3)

D. K. Kocher*, G. Kaur, H.S. Banga, R.S. Brar
1Department of Zoology, Punjab Agricultural University, Ludhiana - 141 004, India

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Cite article:- Kocher* K. D., Kaur G., Banga H.S., Brar R.S. (2024). HISTOPATHOLOGICAL CHANGES IN VITAL ORGANS OF HOUSE RATS GIVEN LETHAL DOSE OF CHOLECALCIFEROL (VITAMIN D3). Indian Journal of Animal Research. 44(3): 193 - 196. doi: .

ABSTRACT

House rats trapped from poultry farms of PAU, Ludhiana (Punjab) were orally administered
with lethal dose (36mg/kg) of cholecalciferol (vitamin D3). Histopathological examination after
single oral intake of cholecalciferol exhibited toxicity in heart in the form of calcification in the
myocardium and in tunica media layer of the coronary blood vessels along with the muscular
necrosis. Marked congestion of alveolar capillaries, hemorrhages in the air spaces, edema,
emphysema were the observations made in the lungs of cholecalciferol fed rats. Mineralisation
was evident both on mucosal and serosal sides of stomach. In kidneys, there was mineralisation
in cortex and medulla. In liver, hepatic cells showed degeneration, dilation of hepatic sinusoids
and marked centrilobular necrosis due to cholecalciferol toxicity.

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