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Current IssueEditorial BoardOnline First ArticlesArchive

volume 44 issue 3 (september 2010) : 193 - 196

HISTOPATHOLOGICAL CHANGES IN VITAL ORGANS OF HOUSE RATS GIVEN LETHAL DOSE OF CHOLECALCIFEROL (VITAMIN D3)

D
D. K. Kocher*
G
G. Kaur
H
H.S. Banga
R
R.S. Brar
1Department of Zoology, Punjab Agricultural University, Ludhiana - 141 004, India

  • Submitted|

  • First Online |

  • doi

Cite article:- Kocher* K. D., Kaur G., Banga H.S., Brar R.S. (2025). HISTOPATHOLOGICAL CHANGES IN VITAL ORGANS OF HOUSE RATS GIVEN LETHAL DOSE OF CHOLECALCIFEROL (VITAMIN D3). Indian Journal of Animal Research. 44(3): 193 - 196. doi: .

ABSTRACT

House rats trapped from poultry farms of PAU, Ludhiana (Punjab) were orally administered
with lethal dose (36mg/kg) of cholecalciferol (vitamin D3). Histopathological examination after
single oral intake of cholecalciferol exhibited toxicity in heart in the form of calcification in the
myocardium and in tunica media layer of the coronary blood vessels along with the muscular
necrosis. Marked congestion of alveolar capillaries, hemorrhages in the air spaces, edema,
emphysema were the observations made in the lungs of cholecalciferol fed rats. Mineralisation
was evident both on mucosal and serosal sides of stomach. In kidneys, there was mineralisation
in cortex and medulla. In liver, hepatic cells showed degeneration, dilation of hepatic sinusoids
and marked centrilobular necrosis due to cholecalciferol toxicity.

REFERENCES

  1. Beasley, V.R. et al. (1997) In : A system affected approach to Veterinary Toxiocology.
  2. Buckle, A. P. and Muller, F. (2000). In: Agrochemicals: Composition, Production, Toxicology and Application (Muller,
  3. .F ed.). Wiley-VCH, Weinheim 667-686p.
  4. Chineme, C. N. et al. (1976). Cornell Vet. 66: 387.
  5. Craigmill, A. (1988). Environ. Toxicol. Newsl. 8(2): 5.
  6. Eason, C. T. et al. (2000). NZ. Plant Prot. 53: 299-304.
  7. Hilbe, M. et al. (2000). Vet. Pathol. 7: 490-492.
  8. Jolly, S. E. et al. (1993). Pestic. Biochem. Physiol. 47: 159-164.
  9. Kaur, G. et al. (2008). Toxicol. Inlt. 15: 143-144.
  10. Kocher, D. K. et al. Toxicol. Intl. 15: 133-136.
  11. Krishnakumari, M. K. et al. In: Rodents in Indian Agriculture (Prakash, I. and Ghosh, P. K. eds). 63-94p.
  12. Luna, L. G. (1968). In: Manual of histological staining methods Armed Forces Institute of Pathology (3rd ed). McGraw
  13. Hill Book Company, New York.
  14. Morrow, Carla D. V. M. (2001). Vet. Med. 12: 905-911.
  15. Saini, M. S. and Parshad, V. R. (1992). Intl. Biodet.Biodr. 30: 87-96.
  16. Simesen, M. G. et al. (1978). Acta Vet. Scand. 19: 588.
  17. Watt, B. E. et al. Toxicol. Rev. 24 (4): 259-269.
  18. Weber, W. J. (1982). In: Diseases transmitted by rats and mice. Thomson Publications, Freno, California. 182 p
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    volume 44 issue 3 (september 2010) : 193 - 196

    HISTOPATHOLOGICAL CHANGES IN VITAL ORGANS OF HOUSE RATS GIVEN LETHAL DOSE OF CHOLECALCIFEROL (VITAMIN D3)

    D
    D. K. Kocher*
    G
    G. Kaur
    H
    H.S. Banga
    R
    R.S. Brar
    1Department of Zoology, Punjab Agricultural University, Ludhiana - 141 004, India

    • Submitted|

    • First Online |

    • doi

    Cite article:- Kocher* K. D., Kaur G., Banga H.S., Brar R.S. (2025). HISTOPATHOLOGICAL CHANGES IN VITAL ORGANS OF HOUSE RATS GIVEN LETHAL DOSE OF CHOLECALCIFEROL (VITAMIN D3). Indian Journal of Animal Research. 44(3): 193 - 196. doi: .

    ABSTRACT

    House rats trapped from poultry farms of PAU, Ludhiana (Punjab) were orally administered
    with lethal dose (36mg/kg) of cholecalciferol (vitamin D3). Histopathological examination after
    single oral intake of cholecalciferol exhibited toxicity in heart in the form of calcification in the
    myocardium and in tunica media layer of the coronary blood vessels along with the muscular
    necrosis. Marked congestion of alveolar capillaries, hemorrhages in the air spaces, edema,
    emphysema were the observations made in the lungs of cholecalciferol fed rats. Mineralisation
    was evident both on mucosal and serosal sides of stomach. In kidneys, there was mineralisation
    in cortex and medulla. In liver, hepatic cells showed degeneration, dilation of hepatic sinusoids
    and marked centrilobular necrosis due to cholecalciferol toxicity.

    REFERENCES

    1. Beasley, V.R. et al. (1997) In : A system affected approach to Veterinary Toxiocology.
    2. Buckle, A. P. and Muller, F. (2000). In: Agrochemicals: Composition, Production, Toxicology and Application (Muller,
    3. .F ed.). Wiley-VCH, Weinheim 667-686p.
    4. Chineme, C. N. et al. (1976). Cornell Vet. 66: 387.
    5. Craigmill, A. (1988). Environ. Toxicol. Newsl. 8(2): 5.
    6. Eason, C. T. et al. (2000). NZ. Plant Prot. 53: 299-304.
    7. Hilbe, M. et al. (2000). Vet. Pathol. 7: 490-492.
    8. Jolly, S. E. et al. (1993). Pestic. Biochem. Physiol. 47: 159-164.
    9. Kaur, G. et al. (2008). Toxicol. Inlt. 15: 143-144.
    10. Kocher, D. K. et al. Toxicol. Intl. 15: 133-136.
    11. Krishnakumari, M. K. et al. In: Rodents in Indian Agriculture (Prakash, I. and Ghosh, P. K. eds). 63-94p.
    12. Luna, L. G. (1968). In: Manual of histological staining methods Armed Forces Institute of Pathology (3rd ed). McGraw
    13. Hill Book Company, New York.
    14. Morrow, Carla D. V. M. (2001). Vet. Med. 12: 905-911.
    15. Saini, M. S. and Parshad, V. R. (1992). Intl. Biodet.Biodr. 30: 87-96.
    16. Simesen, M. G. et al. (1978). Acta Vet. Scand. 19: 588.
    17. Watt, B. E. et al. Toxicol. Rev. 24 (4): 259-269.
    18. Weber, W. J. (1982). In: Diseases transmitted by rats and mice. Thomson Publications, Freno, California. 182 p
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