Indian Journal of Animal Research

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Indian Journal of Animal Research, volume 47 issue 2 (april 2013) : 164-167

GENETIC VARIABILITY OF BOLA-DRB3.2 GENE IN KENKATHA BREED OF CATTLE ASSESSED BY PCR-SSCP

Rakesh Ranjan*, C.D. Bhong1, K.N. Chavan2, S.N.S. Parmar, C.G. Joshi3
1Animal Biotechnology Centre, MPPCVV, Jabalpur 482 004, India

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Cite article:- Ranjan* Rakesh, Bhong1 C.D., Chavan2 K.N., Parmar S.N.S., Joshi3 C.G. (2024). GENETIC VARIABILITY OF BOLA-DRB3.2 GENE IN KENKATHA BREED OF CATTLE ASSESSED BY PCR-SSCP. Indian Journal of Animal Research. 47(2): 164-167. doi: .

ABSTRACT

Present study was conducted to investigate BoLA (Bovine leucocyte antigen) gene polymorphism in indigenous draft Kenkatha (n=52) breed of cattle at DRB3.2 loci by PCR-SSCP (Single strand conformational polymorphism). This BoLA region encodes cell surface glycoprotein, which binds to foreign antigens of T lymphocytes that play central role in the induction and regulation of adaptive immunity. A  PCR-SSCP of 284bp amplicon of BoLA-DRB3.2 gene revealed 13 SSCP patterns. This suggests that exon 2 region of BoLA-DRB3 is highly polymorphic in nature. This may be due to natural selection on a BoLA allele pool, leading to the development of resistance to local infectious diseases.

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