Detection of Outlying Subjects in Bioequivalence Trials

DOI: 10.18805/BKAP202    | Article Id: BKAP202 | Page : 91-93
Citation :- Detection of Outlying Subjects in Bioequivalence Trials.Bhartiya Krishi Anusandhan Patrika.2020.(35):91-93
Sumeet Saurav, Cini Varghese, Seema Jaggi, Mohd Harun and Devendra Kumar
harun.agribhu@gmail.com
Address :
ICAR-Indian Agricultural Statistics Research Institute, PUSA, New Delhi – 110 012, India
Submitted Date : 22-05-2020
Accepted Date : 13-07-2020

Abstract

Evaluation of veterinary medicinal products is one of the important areas where bioequivalence trials are conducted. One of the problems commonly encountered in bioequivalence trials is outlying subjects. These outlying data may occur either as unexpected observations or as the unusual subject who has extremely high or low bioavailability with respect to the reference formulation and may have dramatic effects on the bioequivalence test. Therefore, it is important to examine the data carefully for identification of outlying observations in bioequivalence studies. In this study we have developed another general approach, termed the Estimated Distance (ED), to the outliers’ detection problem.

Keywords

Bioequivalence trials Estimated distance (ED) Likelihood distance (LD) Outliers.

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