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Research Article

Bhartiya Krishi Anusandhan Patrika, volume 35 issue 1-2 (march-june 2020) : 91-93

Detection of Outlying Subjects in Bioequivalence Trials

Sumeet Saurav, Cini Varghese, Seema Jaggi, Mohd Harun, Devendra Kumar
1<div style="text-align: justify;">ICAR-Indian Agricultural Statistics Research Institute, PUSA, New Delhi &ndash; 110 012, India</div>

  • Submitted22-05-2020|

  • Accepted13-07-2020|

  • First Online 10-09-2020|

  • doi 10.18805/BKAP202

Cite article:- Saurav Sumeet, Varghese Cini, Jaggi Seema, Harun Mohd, Kumar Devendra (2020). Detection of Outlying Subjects in Bioequivalence Trials. Bhartiya Krishi Anusandhan Patrika. 35(1): 91-93. doi: 10.18805/BKAP202.

ABSTRACT

Evaluation of veterinary medicinal products is one of the important areas where bioequivalence trials are conducted. One of the problems commonly encountered in bioequivalence trials is outlying subjects. These outlying data may occur either as unexpected observations or as the unusual subject who has extremely high or low bioavailability with respect to the reference formulation and may have dramatic effects on the bioequivalence test. Therefore, it is important to examine the data carefully for identification of outlying observations in bioequivalence studies. In this study we have developed another general approach, termed the Estimated Distance (ED), to the outliers’ detection problem.

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