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Bhartiya Krishi Anusandhan Patrika

The Impact of Emblica officinalis on Altered Biochemical Markers and Oxidative Stress Indices After Sub-acute Enrofloxacin Treatment in Albino Rats

DOI: 10.18805/B-4896    | Article Id: B-4896 | Page : 151-156
Citation :- The Impact of Emblica officinalis on Altered Biochemical Markers and Oxidative Stress Indices After Sub-acute Enrofloxacin Treatment in Albino Rats.Bhartiya Krishi Anusandhan Patrika.2022.(37):151-156
Prateek Mishra, Vidhi Gautam, R.K. Sharma, Sachin Jain, Anushri Tiwari, Vijay Gond pmprateek1@gmail.com
Address : Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh Veterinary Science University, Jabalpur-482 001, Madhya Pradesh, India.
Submitted Date : 6-03-2022
Accepted Date : 3-06-2022
First Online:

Abstract

Background: The current study was conducted at the Department of Veterinary Pharmacology and Toxicology to assess the impact of Emblica officinalis on oxidative stress produced by sub-acute enrofloxacin exposure in albino rats.
Methods: Albino rats weighing 200-300 gram were given enrofloxacin and Emblica officinalis orally through gavage needle and blood samples were taken via capillary tube on the 28th day of the experiment and analysed using laboratory procedures.
Result: Sub-acute treatment of Enrofloxacin at doses of 5 mg/kg b.wt. and 10 mg/kg b.wt. generated oxidative stress in rats, as evidenced by substantial changes in oxidative parameters and affected liver and kidney functions, as seen by changes in biochemical markers of liver and kidney function. Emblica officinalis aqueous extract (200 mg/kg b. wt.) effectively reduces oxidative stress and changes in hepatic and renal function caused by enrofloxacin.

Keywords

​Albino rats Emblica officinalis Enrofloxacin Oxidative stress

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