Agricultural Science Digest

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Agricultural Science Digest, volume 41 issue 3 (september 2021) : 516-519

Spontaneous Mammary Tumor with Concurrent Cavernous Hemangioma in Albino Mice- A Rare Case Report from Mizoram, India

Y. Damodar Singh, Rahul Singh Arya, R. Ravindran, Tridib Kumar Rajkhowa
1Department of Veterinary Pathology, College of Veterinary Sciences and Animal Husbandry, Central Agricultural University, Selesih, Aizawl-796 015, Mizoram, India.
Cite article:- Singh Damodar Y., Arya Singh Rahul, Ravindran R., Rajkhowa Kumar Tridib (2021). Spontaneous Mammary Tumor with Concurrent Cavernous Hemangioma in Albino Mice- A Rare Case Report from Mizoram, India. Agricultural Science Digest. 41(3): 516-519. doi: 10.18805/ag.D-5258.
Background: Mouse mammary tumor is a common neoplasm of the species. Mice is an established model for human breast cancer studies and in recent times for transgenic studies. Hemangiomas are tumors of blood vascular system. Hemangioma with breast cancer is reported in human beings. Presented study describes an unusual case of concurrent mouse mammary tumor and cavernous hemangioma from Mizoram, India.
Methods: A mortality of 8 out of a colony of 25 female albino mice was observed due to mammary tumors. Dead mice were thoroughly necropsied and tissue samples were collected from different parts of each tumor mass and fixed in neutral buffered formalin. The fixed tissues were processed for hematoxylin and eosin staining by routine paraffin embedding, microtomy and staining protocol. 
Result: Gross examination revealed variable sized tumors on abdomen of affected mice. Histopathology revealed two different forms of mammary tumor viz, acinar and solid mammary carcinoma. Most peculiar finding was remarkable presence of large, endothelial lined cavernous spaces with presence of stagnant blood. These were diagnosed as cavernous hemangioma. Perusal of available literature did not reveal any report of cavernous hemangioma occurring with mouse mammary tumor, while it is found in other species including human beings.
  1. Adiga, P.G., Shridhar, N.B., Sanganal, J.S., Rao, S., Shilpa, N., Aparna, V., Santhosh, I.M., Tirumala, M. and Sindhu, B.M. (2018). In vivo anti-tumor efficacy of Croton oblongifolius in DMBA induced mammary tumor in rats. Indian J. Anim. Res. 52(1): 144-147.
  2. Ash, P. and Loutit, J.F. (1977). The ultrastructure of skeletal hemangiosarcomas induced in mice by Strontium-90. J. Pathol. 122: 209-218.
  3. Bautch, V.L., Toda, S., Hassell, J.A. and Hanahan, D. (1987). Endothelial cell tumors develop in transgenic mice carrying polyoma virus middle T oncogene. Cell. 51: 529-37.
  4. Booth, C.J. and Sundberg, J.P. (1995). Hemangiomas and hemangiosarcomas in inbred laboratory mice. Lab. Anim. Sci. 45: 497-502.
  5. Cardiff, R.D., Anver, M.R., Gusterson, B.A., Hennighausen, L., Jensen, R.A., et al. (2000). The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting. Oncogene. 19: 968-988.
  6. Dahal, M., Upadhyaya, P., Adhikari, P., Karki, D. and Regmi, N. (2018). Ovarian Hemangioma: A rare entity. Int. J. Reprod. Contracept. Obstet. Gynecol. 7: 2490-2.
  7. Dunn, T.B. (1959). Morphology of mammary tumors in mice. In: The Pathophysiology of Cancer. Editor-Homburger F. Publisher- Hoeber, New York. pp 38-84.
  8. Gupta, P., Raghunath, M., Gupta, A.K., Sharma, A. and Kour, K. (2014). Clinical study for diagnosis and treatment of canine mammary neoplasms (CMNS) using different modalities Indian J. Anim. Res. 48(1): 45-49. DOI- 10.5958 /j.0976-0555.48.1.009.
  9. Hardisty, J.F., Elwell, M.R., Ernst, H., Greaves, P., Kolenda-Roberts, H., Malarkey, D.E., Mann, P.C. and Tellier, P.A. (2007). Histopathology of hemangiosarcomas in mice and hamsters and liposarcomas/fibrosarcomas in rats associated with PPAR agonists. Toxicol. Pathol. 35: 928-941.
  10. Kakiuchi-Kiyota, S., Crabbs, T.A., Arnold, L.L., Pennington, K.L., Cook, J.C., Malarkey, D.E. and Cohen, S.M. (2013). Evaluation of expression profiles of hematopoietic stem cell, endothelial cell, and myeloid cell antigens in spontaneous and chemically induced hemangiosarcomas and hemangiomas in mice. Toxicol. Pathol. 41: 709-721. 
  11. Kawatra, V., Lakshmikantha, A., Dhingra, K.K., Gupta, P. and Khurana, N. (2009). A rare coexistence of concurrent breast hemangioma with fibroadenoma: a case report. Cases J. 2: 7005-7007.
  12. Kim, S.J., Han, H.S., Kim, J.S., Park, J.H., Jeon, H.J. and Jeong, G.Y. (2006). Cavernous hemangioma of the breast parenchyma with unusual features. J. Ultrasound Med. 25: 1343-1346.
  13. Luna, L.G. (1968). Manual of Histologic Staini., Percy, D.H. and Barthold, S.W. (2007). Pathology of Laboratory Rodents and Rabbits. 3rd edition, Blackwell Publishing. pp 171-173.
  14. Rajdeo, R.N., Umap, P.S., Bajaj, J. and Shrikhande, A.V. (2015). Coexistence of breast hemangioma with fibroadenoma: a rare case report. Int. J. Res. Med. Sci. 3: 1266-1268.
  15. Sass, B. and Dunn, T.B. (1979). Classification of mouse mammary tumors in Dunn’s miscellaneous group including recently reported types. J. Natl. Cancer Inst. 62: 1287-1293.
  16. Thangapandiya, M., Selvaraj, J., Preetha, S.P. and Gayathri Devi, R. (2011). Spontaneous mammary fibroadenomas in a wistar rat colony. Indian J. Anim. Res. 45(4): 322-323.
  17. Veena, P., Kumar, R.V.S., Raghavender, K.V.B., Srilatha, C. and Rao, T.S.C. (2013). Electron microscopic studies of canine mammary tumors. Indian J. Anim. Res. 47(3): 257-258.
  18. Veena, P., Kumar, R.V.S., Raghavender, K.B.P., Srilatha, C. and Rao, T.S.C. (2014). Immunohistochemical detection of p53 in canine mammary tumors. Indian J. Anim. Res. 48(2): 204-206 .
  19. Winer, L.H. (1952). Hemangiomas, histologic structure and treatment. Cal. Med. 77(4): 242-247.

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