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Research Article

Agricultural Science Digest, volume 39 issue 3 (september 2019) : 254-256

Real-time Expression of Stemness and Self-Renewal Genes in Canine Hematopoietic Progenitor Cells

S. Nandhini, Gowri A. Mangala, G.R. Baranidharan, T.V. Meenambigai
1Department of Animal Biotechnology, CSCRRM, Madras Veterinary College, Chennai-7,India
Cite article:- Nandhini S., Mangala A. Gowri, Baranidharan G.R., Meenambigai T.V. (2019). Real-time Expression of Stemness and Self-Renewal Genes in Canine Hematopoietic Progenitor Cells. Agricultural Science Digest. 39(3): 254-256. doi: 10.18805/ag.D-4929.

ABSTRACT

Blood cells are responsible for constant maintenance and immune protection of every cell type of the body and this relentless and brutal work requires cells that have the greatest powers of self-renewal and are designated as Hematopoietic progenitor cells (HPCs).Peripheral blood stem cells in circulation have become the most common source of hematopoietic stem cells intended for transplantation after minimal manipulation. Homeo box (Hox), sonic hedgehog (SHH), and Wingless-type MMTV integration site family (Wnt) are known to modulate the self-renewal and expansion of hematopoietic progenitor/stem cells in humans and mice. Unlike cytokines, Hox, SHH, and Wnt are highly conserved among species from flies to humans but studies regarding the self-renewal and expansion of the HSC are extremely limited in dogs.

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