Agricultural Reviews

  • Chief EditorPradeep K. Sharma

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Agricultural Reviews, volume 36 issue 1 (march 2015) : 46-53

Transgenic animal technology: Recent advances and applications: A Review

Rakesh Kumar*, Alok Kumar Yadav, Vikas Kumar Singh, Rajesh Kumar Vandre, Pankaj Kumar Singh, Nishant Verma, Ramendra Das, M.R. Vineeth
1Dairy Cattle Breeding Division, ICAR-National Dairy Research Institute, Karnal-132 001, Haryana.
Cite article:- Kumar* Rakesh, Yadav Kumar Alok, Singh Kumar Vikas, Vandre Kumar Rajesh, Singh Kumar Pankaj, Verma Nishant, Das Ramendra, Vineeth M.R. (2024). Transgenic animal technology: Recent advances and applications: A Review. Agricultural Reviews. 36(1): 46-53. doi: 10.5958/0976-0741.2015.00005.7.

ABSTRACT

Transgenic animal technologies are one of the fastest growing techniques in the biotechnology areas. It is used to incorporate exogenous genes into the animal genome by genetic engineering technology so that these genes can be inherited and expressed by offspring. Two fundamental determinants of the success of any transgenic exploitation of a livestock species are the transport of DNA across the plasma membrane of the recipient cell, and the transport of that DNA across the nuclear membrane to gain access to the chromosomes. A variety of transgenic technologies are available like microinjection method, chemical method mediated transgenesis, somatic cell nuclear transfer, restriction enzyme-mediated integration, retrovirus-mediated gene transfer, sperm mediated gene transfer and embryonic stem cell mediated method etc. Use of transgenic animals will provide solutions for drug research, xenotransplantation, disease resistance and tissue repair etc. This review focuses on various methods of transgenesis and its application.

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