Agricultural Reviews

  • Chief EditorPradeep K. Sharma

  • Print ISSN 0253-1496

  • Online ISSN 0976-0741

  • NAAS Rating 4.84

Frequency :
Quarterly (March, June, September & December)
Indexing Services :
AGRICOLA, Google Scholar, CrossRef, CAB Abstracting Journals, Chemical Abstracts, Indian Science Abstracts, EBSCO Indexing Services, Index Copernicus
Submit

Agricultural Reviews, volume 28 issue 3 (september 2007) : 207-215

LEPTIN GENE AND ITS ROLE IN CATTLE- A REVIEW

P. P. Dubey, Ashwani Sharma, Dinesh Kumar*
1Dairy Cattle Breeding Division. National Dairy Research Institute, Karnal-132001

  • Submitted|

  • First Online |

  • doi

Cite article:- Dubey P. P., Sharma Ashwani, Kumar* Dinesh (2024). LEPTIN GENE AND ITS ROLE IN CATTLE- A REVIEW. Agricultural Reviews. 28(3): 207-215. doi: .

ABSTRACT

Interest in the bovine leptin gene has increased during the last few years. Leptin, a 16-kDa protein secreted from white adipocytes which is involved in regulation of feed intake, milk yield, energy balance, fertility, and immune functions in animals. The gene encoding leptin was identified by positional cloning and is the mutation leading to the profound obese phenotype of the ob/ob mouse. Exogenous administration of leptin in ob/ob mice leads to a significant improvement in reproductive and endocrine status as well as reduced food intake and weight loss. The frequency of polymorphism in leptin gene has been found to be very high in beef and dairy cattle. Some association studies have been carried out in beef, dairy and fertility traits of cattle like energy balance, feed intake, live weight, fat deposition, milk yield and protein yield. These associations will provide insight in to the underlying mechanism of leptin and polymorphism can be used for selection of beef and dairy cows.

KEYWORDS

    REFERENCES

    1. Ahima, R. S., and Flier. J. S. (2000). Leptin. Annu Rev Physiol 62:413-437.
    2. Ahima, R. S. et al. (1997). J Clin Invest. 99:391-395.
    3. Almeida, S. E. M. et al. (2003). J Animal Breed Genet 120:106-113.
    4. 214 AGRICUTURAL REVIEWS
    5. Amico, J. A. et al. (1998). Life Sci 63:1387-1395.
    6. Amstalden, M. et al. (2003). Biol Reprod 69:1539-1544.
    7. Amstalden, M. et al. (2002). Biol Reprod 66:1555-1561.
    8. Amstalden, M. et al. (2000). Biol Reprod . 63:127-133.
    9. Barb, C. R. et al. (1998).Domest Anim Endocrinol 15:77-86.
    10. Blache, D. et al. (2000). J. Endocrinol 165:625-637.
    11. Block, S. S. et al. (2003a). J Dairy Sci 86:3206-3214.
    12. Block, S. S. et al. (2001). J Endocrinol 171:339-348.
    13. Brogan, R. S. et al. (2000). J Neuroendocrinol 12:1077-1086.
    14. Brogan, R. S. et al. (1999). Endocrinology 140:2621-2627.
    15. Buchanan, F. C. et al. (2003). J Dairy Sci 86:3164-3166.
    16. Buchanan, F. C. et al. (2002). Genet Sel Evol 34: 105-116.
    17. Campfield, L. A. et al. (1995). Science 269:546-549.
    18. Chehab, F. F. et al. (1997). Science 275:88-90.
    19. Chehab, F. F. et al. (1996). Nat Genet 12:318-320.
    20. Chilliard, Y. et al. (2000). Proc Nutr Soc59:127-134.
    21. Choudhary V. et al. (2005). Genetics and Molecular Biology, 28 (4):740-742.
    22. Considine, R. V. et al. (1996). Diabetes 45:992-994.
    23. Darlington, G. J. et al. (1995). Curr Opin Genet Dev 5:565-570.
    24. De la Brousse, F. C. et al. (1996). Proc Natl Acad Sci U S A 93:4096-4101.
    25. Delavaud, C. et al. (2002). J Anim Sci 80:1317-1328.
    26. Delavaud, C. et al. (2000). J Endocrinol 165:519-526.
    27. Dyer, C. J. et al. (1997). Domest Anim Endocrinol 14:119-128.
    28. Ehrhardt, R. A. et al. (2001). Domest Anim Endocrinol 21:85-96.
    29. Ehrhardt, R. A. et al. (2000). J Endocrinol 166:519-528.
    30. Finn, P. D. et al. (1998). Endocrinology 139:4652-4662.
    31. Fitzsimmons, C. J. et al. (1998). Mamm Genome 9: 432-434.
    32. Forhead, A. J. et al. (2002). Endocrinology 143:1166-1173.
    33. Garcia, M. D. et al. (2000). Biol Reprod 62:698-703.
    34. Garcia, M. R. et al. (2002). J Anim Sci 80:2158-2167.
    35. Grosfeld, A et al. (2002). J Biol Chem 277:42953-42957.
    36. Gruaz, N. M. et al. (1998). J Neuroendocrinol 10:627-33.
    37. Haegeman, A. et al. (2000). Anim Genet 31:79.
    38. Hager, J. et al. (1995). Science 269:543-546.
    39. Hamann, A. et al. (1996). Exp. Clin.Endocrinol. Diabetes 104:293-300.
    40. Havel, P. J. et al. (1996). Nat Med 2:949-950.
    41. He, Y. et al. (1995). J Biol Chem 270:28887-28891.
    42. Henry, B. A. et al. (2001).J Endocrinol 168:67-77.
    43. Henry, B. A. et al. (1999). Endocrinology 140:1175-1182.
    44. Henry, B. A. et al. (1999). Endocrinology 140:1175-1182.
    45. Hiroike, T. et al. (2000). Biochem Biophys Res Commun 275:154-158.
    46. Hollenberg, A. N. et al. (1997). J Biol Chem 272:5283-5290.
    47. Horlick, M. B. et al. (2000). J Clin Endocrinol Metab 85:2509-2518.
    48. Hwang, C. S. et al. (1996).Proc Natl Acad Sci U S A 93:873-877.
    49. Jang, M. et al. (2000). J Nutr 130:2813-2820.
    50. Jiang, Z. H., and J. P. Gibson. (1999). Mamm Genome 10:191-193.
    51. Kieffer, T. J. et al. (1996). Biochem Biophys Res Commun 224:522-527.
    52. Kim, J. B. et al. (1998). J Clin Invest 101:1-9.
    53. Konfortov, B. A. et al. (1999). Mamm Genome 10: 1142-1145.
    54. Lagonigro, R. et al. (2003). Anim Genet 34:371-374.
    55. Leclercq-Meyer, V. et al. (1998. Mol Cell Endocrinol 141:111-118.
    56. Leclercq-Meyer, V. et al. (1996). Biochem Biophys Res Commun 229:794-798.
    57. Leroy, P. et al. (1996). J Biol Chem 271:2365-2368.
    58. Liefers, S. C. et al. (2002). J Dairy Sci 85: 1633-1638.
    59. Liefers, S. C. et al. (2003a). J Dairy Sci 86: 799-807.
    60. Lindersson, M. et al. (1998). J. Dairy Sci. 81:1454-1461.
    61. Vol. 28, No. 3, 2007 215
    62. Maffei, M. et al. (1995). Nat Med 1:1155-1161.
    63. Marie, M. et al. (2001). J Endocrinol 170:277-286.
    64. Mason, M. M. et al. (1998). Endocrinology 139:1013-1022.
    65. Matkovic, V. et al. (1997). J Clin Endocrinol Metab 82:3239-3245.
    66. Meissner, U. et al. (2003). Biochem Biophys Res Commun 303: 707-712
    67. Miller, S. G. et al. (1996). Proc Natl Acad Sci U S A 93:5507-5511.
    68. Montague, C. T. et al. (1997). Nature 387:903-908.
    69. Morrison, C. D. et al. (2001). J Endocrinol 168:317-324.
    70. Morrison, C. D. et al. (2002). Anim Endocrinol 22:103-112.
    71. Mounzih, K. et al. (1998). Endocrinology 139:5259-5262.
    72. Mukherjea, R. et al. (1999). Life Sci 65:1183-1193.
    73. Ohshiro, Y. et al. (2000). J Mol Med 78:516-520.
    74. Orbak, Z. et al. (2001). J Pediatr Endocrinol Metab 14:185-192.
    75. Ozata, M. et al. (1999). J Clin Endocrinol Metab 84:3686-3695.
    76. Pfister-Genskow, M. et al. (1996). Mamm Genome 7:398-399.
    77. Pickavance, L. et al. (1998). Biochem Biophys Res Commun 248:196-199.
    78. Poitout, V. et al. (1998). Diabetes Metab 24:321-326.
    79. Pomp, D. et al. (1997). J Anim Sci 75:1427.
    80. Ren, M. Q. et al. (2002). Domest Anim Endocrinol 23:371-381.
    81. Rock, F. L. et al. (1996). Horm Metab Res 28:649-652.
    82. Rosenbaum, M. et al. (1996). J Clin Endocrinol Metab 81:3424-3427.
    83. Seeber, R. M. et al. (2002). Biol Reprod 66:1762-1767.
    84. Strobel, A. et al. (1998). Nat Genet 18:213-215.
    85. Tang-Christensen, M. et al. (1999). J Clin Endocrinol Metab 84:711-717.
    86. Taniguchi, Y. et al. (2002). IUBMB Life 53:131-135.
    87. Tanizawa, Y. et al. (1997). Endocrinology 138:4513-4516.
    88. Thomas, L. et al. (2001). J Endocrinol 169:465-476.
    89. Tomimatsu, T. et al. (1997). Biochem Biophys Res Commun 240:213-215.
    90. Watanobe, H. 2002). J Physiol 545:255-268.
    91. Williams. 2003b). Exp Biol Med (Maywood) 228:325-330.
    92. Woller, M. et al. (2001). Exp Biol Med (Maywood) 226:591-596.
    93. Woodside, B. et al. (2000). Horm Behav 37:353-365.
    94. Zhang, F. et al. (1997). Nature 387:206-209
    95. Zhang, Y. et al. (1994). Nature 372:425-432.
    Reviewed By

    Download Article
    In this Article
      Contact us
      Follow us

      Editorial Board

      View all (0)